Prevention of Preeclampsia and Intrauterine Growth Restriction With Aspirin Started in Early Pregnancy

Bujold, Emmanuel; Roberge, Stéphanie; Lacasse, Yves; Bureau, Marc; Audibert, François; Marcoux, Sylvie; Jc, Forest; Giguère, Yves

doi:10.1097/aog.0b013e3181e9322a

Cited by 1,005 publications

(761 citation statements)

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“…17 Recently, however, a meta-analysis that collected data from 11 748 women was able to show that the administration of aspirin at low doses before the 16th week of gestation resulted in a relative risk of pre-eclampsia of 0.44. 18 In contrast, the improvement is completely absent when the treatment is given after the 16th week. This discrepancy is probably the major reason for the existence of contradictory results in many studies of aspirin administration during gestation.…”

Section: Introductionmentioning

confidence: 82%

Prevention of gravidic endothelial hypertension by aspirin treatment administered from the 8th week of gestation

Bakhti

Vaiman

2011

Hypertens Res

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The aim of this study was to evaluate whether low doses of aspirin (100 mg per day) administered to a homogeneous population of women early (8-10 weeks) during their first pregnancy improved the outcome of gestation hypertensive disorders. This study was performed at the Blida Hospital, where many early deliveries and pregnancy complications are observed. A total of 164 women were either treated (82) or used as controls (82). Treatment increased the gestation length by 12 days on average, thus triggering an approximate 150-g increase in newborn weight. This consistently improved the outcome for all patients with respect to all parameters investigated. Overall, the relative risk of developing hypertensive disorders of gestation was reduced to 0.07 (confidence interval¼0.01-0.51). In our series, we did not observe deleterious consequences for the fetus (teratogenicity and fetotoxicity) or adverse outcomes for the mothers. Despite the limited number of patients analyzed, the present study is one of the largest investigating early aspirin treatment of gestational hypertensive diseases. In addition, the time of aspirin administration is among the earliest yet examined. The data tend to confirm the results obtained from other cohorts on the overall benefit of aspirin treatment for gestational disorders. In the future, molecular or ultrasonographic markers of these diseases could help to screen patients before applying the treatment.

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Section: Introductionmentioning

confidence: 82%

Prevention of gravidic endothelial hypertension by aspirin treatment administered from the 8th week of gestation

Bakhti

Vaiman

2011

Hypertens Res

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“…In the third trimester, aspirin increases the risk of constriction of fetal ductus arteriosus, leading to pulmonary hypertension [4,13]. Therefore, it is advisable to take aspirin only at a low dosage of 50 to 150 mg daily, if indicated [19].…”

Section: Discussionmentioning

confidence: 99%

Medications Used by Pregnant Women: Any Safety Concerns?

Kho

Chua

Dallumal

et al. 2017

Int J Pharm Pharm Sci

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Objective: The use of medications during pregnancy may impose a potential risk to the fetus. Therefore, this study was conducted to determine the prevalence and safety of medications used by pregnant women. Methods:A cross-sectional study was conducted on pregnant women who attended the antenatal clinic of a major teaching hospital in Malaysia, from January to April 2013. Data was collected via face-to-face interviews using a structured questionnaire. Results:Of the 500 respondents in this study, 62% (95% confidence interval, CI: 57.7%, 66.3%) used at least one medication during their pregnancy and 30.8% (95% CI: 26.8%, 34.8%) took the medications during the first trimester. The classes of medications commonly used were analgesics (26.8%), followed by cough and cold medications (18.6%) and medications for gastrointestinal disorders (11.8%). Among the 697 medications used by the respondents during pregnancy, most of them were relatively safe, with approximately 50% being classified under the Food and Drug Administration of the United States (FDA, US)-assigned pregnancy category B. However, seven potentially teratogenic medications were identified, including four antiepileptic drugs and an antimigraine medication which contained ergotamine. Conclusion:This study found that a high proportion of pregnant woman consumed at least one medication during their pregnancy. The use of antimigraine medications containing ergotamine in pregnant women is of major concern as this medication could be obtained without a prescription in some countries, including in Malaysia. Therefore, it is essential for health care professionals to educate and counsel pregnant women on the safety of medications used.

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“…Existe amplia evidencia que avala este procedimiento en un modelo predictivo de PES en la población general de embarazadas, con tasas de detección de 90% 19,20 y que ha permitido la intervención farmacológica preventiva en pacientes de alto riesgo [21][22][23][24] .…”

Section: Causas De Ingreso a Uciunclassified

Morbilidad materna grave e ingreso a cuidado intensivo: Hospital Clínico Universidad de Chile (2006-2010)

Sepúlveda‐Martínez

et al. 2013

Rev. méd. Chile

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Prevention of Preeclampsia and Intrauterine Growth Restriction With Aspirin Started in Early Pregnancy

Abstract: Low-dose aspirin initiated in early pregnancy is an efficient method of reducing the incidence of preeclampsia and IUGR.

Cited by 1,005 publications

References 69 publications

Prevention of gravidic endothelial hypertension by aspirin treatment administered from the 8th week of gestation

Prevention of gravidic endothelial hypertension by aspirin treatment administered from the 8th week of gestation

Medications Used by Pregnant Women: Any Safety Concerns?

Morbilidad materna grave e ingreso a cuidado intensivo: Hospital Clínico Universidad de Chile (2006-2010)

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