Prevention of rat breast cancer by genistin and selenium

Abstract

Breast cancer is the second leading cause of cancer death among women and the third most common cancer. In this study, we investigated the chemoprevention efficacy of each of soy genistin, selenium or a combination of them against breast cancer. Seventy-five female rats were divided into five groups : control group (I); 7,12-dimethylbenz(a)anthracene (DMBA) group (II); DMBA treated with genistin group (III); DMBA treated with selenium group (IV); and DMBA treated with genistin combined with selenium group (V). The treatments were daily administered for 3 months. There were a significant decrease in body weight and serum total antioxidant, while a significant elevation in serum total sialic acid, carcinoembryonic antigen, prolactin, estradiol, nitric oxide, and malondialdhyde of DMBA injected rats compared with control group. Administration of genistin and selenium was associated with decreasing levels of tumorigenicity, endocrine derangement, and oxidative stress. Formation of breast carcinoma in DMBA-induced rats and abnormal changes were ameliorated in the rats treated with genistin/selenium or genistin alone. Supplementation of genistin alone or with selenium provided antioxidant defense with high-potential chemopreventive activity against DMBA-induced mammary tumors more than selenium alone.

<em>Ulva lactuca</em> polysaccharides prevent Wistar rat breast carcinogenesis through the augmentation of apoptosis, enhancement of antioxidant defense system, and suppression of inflammation

“…These results are consistent with the results which found that serum and tissue lipid peroxidation and NO level were increased significantly in the breast cancer-bearing animals induced by DMBA 9. The present results are also in agreement with many previous reports 52,62–66. In consistency with the present study, the results of another study showed that an increase in the MDA level was observed in the lactiferous ducts of rats exposed to DMBA 67.…”

“…In addition, a substantial decrease in breast GSH content was detected. These results are in accordance with other studies66,93 which revealed that the total antioxidant level was detectably decreased in the serum of DMBA group as compared with the control group. Moreover, the present study is in agreement with Kaufmann et al33 who reported that the enzymic antioxidant SOD, CAT, and GPx levels in cancer-induced animals were reduced when compared to the control animals.…”

Measurement and correlation of the solubility of genistin in eleven organic solvents from T=(283.2 to 323.2)K

“…Genistin has attracted much attention due to its wide variety of pharmacological activities, such as weak oestrogen activity [1], antioxidant activity [2,3], hemolysis activity and antibacterial activity [4]. It is also considered as an effectual preventive for breast cancer [5], colon cancer [6], osteoporosis [7] and so on. Therefore, Genistin is often used as dietary supplements [8].…”

Distribution of Selenium and Oxidative Stress in Breast Tumor-Bearing Mice

“…By contrast, mammary tissue Se was not lower in TB mice; one possible explanation for this result is that decreased mammary fat pad contents were observed compared with CNL animals. It appears that alterations in Se concentrations occur during cancer development [23]; whereas improved Se status associated with decreased oxidative stress may be useful for preventing the progression of breast cancer [46]. …”