Prevention of Rat Fissure Caries by Sodium Fluoride Varnish (Duraphat®) with Different Fluoride Concentrations

Seppä, Liisa; Forss, Helena; Sormunen, P.

doi:10.1159/000261208

Cited by 6 publications

(2 citation statements)

References 11 publications

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“…The costs of applying the varnish more or less often were assessed in a sensitivity analysis. While a dose‐response gradient between fluoride concentration and effect seems likely, there were insufficient data for determining exactly whether a different application frequency was also associated with different effectiveness. We thus assumed that the effectiveness did not differ by application frequency.…”

Section: Methodsmentioning

confidence: 99%

Cost‐effectiveness of caries‐preventive fluoride varnish applications in clinic settings among patients of low, moderate and high risk

Schwendicke

Splieth

Thomson

et al. 2017

Comm Dent Oral Epid

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Objectives: The total body of evidence finds fluoride varnish effective to prevent caries. However, most trials were conducted in high-risk populations, with more recent trials on low-risk groups finding a lower efficacy. We aimed to assess the cost-effectiveness of fluoride varnish application in clinic setting in populations with different caries risk.Methods: A mixed public-private-payer perspective in the context of German health care was performed using a lifetime Markov model. Effectiveness data were derived from an update of the most recent systematic Cochrane review and synthesized in three different risk groups according to control group caries increment via randomeffects meta-analysis. Varnish was assumed to be applied twice yearly between age 6 and 18 years. Teeth with carious defects would be treated restoratively and could experience further follow-up treatments. Costs were deduced from German fee item catalogues. Monte Carlo microsimulations were used for to analyse lifetime treatment costs and caries increment (Euro/Decayed, Missing, Filled Teeth (DMFT)).

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Section: Methodsmentioning

confidence: 99%

Cost‐effectiveness of caries‐preventive fluoride varnish applications in clinic settings among patients of low, moderate and high risk

Schwendicke

Splieth

Thomson

et al. 2017

Comm Dent Oral Epid

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“…However there have been no studies reported examining the anticaries efficacy of low-fluoride professional preparations on preschool children, and reports have been confined to animal stud ies. No significant reduction in caries efficacy has been found in rats [Hefti, 1982: Seppa et al, 1989], Hagan and Bawden [1985] have presented data of a clinical study in which full-and half-strength APF operator-applied treat ments were evaluated, but this work was conducted on older children (11-to 15-year-olds).…”

mentioning

confidence: 99%

Caries-Preventive Effect of Two Different Topical Fluoride Concentrations with Two Different Frequencies of Application in Preschool Children

Linčir

Rošin-Grget²

1993

Caries Res

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The effects of standard topical amine fluoride solution (1% F) and a low-fluoride solution (0.5% F) with two different frequencies of application (5 and 10 times a year) on 2 years dental caries increment were compared in a double-blind clinical trial involving 199 kindergarten children. The results suggest that increased frequency of application of a low fluoride topical solution (10 times a year) may provide caries protection in preschool children with relatively high caries activity.

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Caries incidence after topical application of varnishes containing different concentrations of sodium fluoride: 3‐year results

Haugejorden

Nord²

1991

European J Oral Sciences

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Abstract— Previous studies have shown that topical application of the fluoride varnish Duraphat reduces caries incidence. The aim of the present study was to compare the caries inhibiting effect of a new fluoride varnish (Carex) containing 1.8% fluoride (F) with that of Duraphat (2.26%F). Informed consent was obtained from the guardians of 495 children 10‐12 yr old in Voss Dental Health District (low F area). The children were randomly allocated to two groups. One group of subjects received 6‐monthly application of Duraphat (n=185), the other Carex (n=165). Ethical considerations precluded the use of a placebo varnish. All participants received dental examinations including one pair of posterior bitewing radiographs and necessary dental care annually. One trained examiner interpreted bitewing radiographs blindly. Total 3‐yr net DFS increment for 24 posterior approximal surfaces was 2.63 (SD = 3.81) in the Duraphat group and 2.12 (SD = 3.50) in the Carex group. DMFS increments based on 40 posterior occlusal and approximal surfaces were 5.21 (SD = 5.79) and 4.04 (SD = 4.92), respectively. Thus the results indicate a comparable efficacy for Carex and Duraphat at the caries activity level exhibited by these study participants.

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Prevention of Rat Fissure Caries by Sodium Fluoride Varnish (Duraphat®) with Different Fluoride Concentrations

Cited by 6 publications

References 11 publications

Cost‐effectiveness of caries‐preventive fluoride varnish applications in clinic settings among patients of low, moderate and high risk

Cost‐effectiveness of caries‐preventive fluoride varnish applications in clinic settings among patients of low, moderate and high risk

Caries-Preventive Effect of Two Different Topical Fluoride Concentrations with Two Different Frequencies of Application in Preschool Children

Caries incidence after topical application of varnishes containing different concentrations of sodium fluoride: 3‐year results

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