Prevention of Recurrent Bacteriuria with Continuous Chemotherapy

Freeman, Richard B.; Bromer, Louis; Brancato, Frank P.; Cohen, Stanford I.; Garfield, Claude F.; Griep, Robert J.; Hinman, Edward J.; Richardson, James A.; Thurm, Richard H.; Urner, Christfried; Smith, William M.

doi:10.7326/0003-4819-69-4-655

Cited by 39 publications

(7 citation statements)

References 38 publications

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“…First, most of our patients with scarred kidneys had concomitant and/or previous upper tract stone disease. The association between upper tract stones and focal renal scarring has certainly been described in previous articles [6, 7, [14][15][16][17][18].…”

Section: Methodsmentioning

confidence: 75%

The relationship between renal scarring and stone disease

Newhouse¹,

Amis²

1988

American Journal of Roentgenology

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Section: Methodsmentioning

confidence: 75%

The relationship between renal scarring and stone disease

Newhouse¹,

Amis²

1988

American Journal of Roentgenology

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“…Definitions of a positive microscopic examination have varied, but most authors used the detection of 21 microorganism per OIF for visible bacteriuria, and 210 WBCs per high-power field for pyuria. Examination of the sediment of centrifuged urine has not usually yielded better results than examination of an uncen-STAINED SMEARS AND AMS IN BACTERIURIA DETECTION trifuged specimen (2,10,15,23,26,28), but most reports suggest that staining the urine smear improves the reliability of the results over those obtained with direct, unstained smears (14,22,32).…”

Section: Discussionmentioning

confidence: 99%

“…Both the cleaned and the standard Gram-stained slides were later read blindly by a microbiologist (F.P.B.) who is a recognized expert in Gram stain interpretation (5,14). The two slides of each set were overlaid with immersion oit and arranged in random order to ensure that the microbiologist was unaware of which type of slide he was reading.…”

Section: Methodsmentioning

confidence: 99%

Comparison of the automicrobic system, acridine orange-stained smears, and gram-stained smears in detecting bacteriuria

Lipsky¹,

Plorde²,

Tenover³

et al. 1985

J Clin Microbiol

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We compared the accuracy of the Gram-stained smear, the acridine orange-stained smear, and the AutoMicrobic system (AMS; Vitek Systems, Inc., Hazelwood, Mo.) in screening for bacteriuria, as detected by conventional cultures. For 1,024 clinical specimens, results with the acridine orange-stained smear and the Gram-stained smear were very similar. When read for the presence of one or more microorganisms or leukocytes per 20 oil immersion fields, both smears were highly sensitive (92.1 and 93.3%, respectively) and moderately specific (70.0 and 61.7%, respectively). Sensitivity was greater for specimens yielding i105 CFU/ml (96.1 and 98.9%, respectively) than for those with 103 to 104 CFU/ml (81.4 and 78.0%, respectively). Preliminary classification based upon the tinctorial and morphological characteristics of the Gram-stained smear was compatible with culture results in nearly all cases. The accuracy of the Gram-stained smears was not influenced by special cleaning of the microscopic slides, or the level of expertise of the microscopist. For 715 specimens, the sensitivity of the AMS in detecting bacteriuria (91.5%) was very similar to that of the stained smears (92.1 and 95.7%, respectively), but the specificity was significantly higher (83.2% versus 42.6 and 70.0%). Detection of microorganisms by the AMS took an average of 6.3 3.0 h. These data suggest that the Gram-stained smear is easily interpreted, very sensitive, acceptably specific, and still the optimal rapid method for screening for bacteriuria in most clinical microbiology laboratories.

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“…Previous studies have shown that long term prophylactic treatment with anti-bacterial agents is superior to placebo or no treatment in preventing bacteriuria. 2 The present study was designed to compare four different agents which might be used in the prophylaxis of recurrent bacteriuria. Penicillin G is not widely used because its effect against most Coliform and Proteus Spp.…”

mentioning

confidence: 99%