Prevention of sepsis and multiple organ failure in critically ill patients

Sigurdsson, G. H.

doi:10.1111/j.1399-6576.1995.tb04263.x

Cited by 5 publications

(1 citation statement)

References 46 publications

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“…Since the gastrointestinal tract is a likely source of MOF in critical illness [28,38], some investigators have concentrated their attention not only on the blood supply, but also on the blood flow pattern in the gastrointestinal tract [39][40][41], It has been shown that periodic constriction and relaxation of the terminal arterioles is a natural prop erty of the microcirculation. This has been termed vasomotion [42,43] and the resulting rhythmical variation in microcirculatory blood flow has been termed flowmotion [42].…”

Section: Icrocirculatory Flowm Otion In the Intestinal M U Co Samentioning

confidence: 99%

Microcirculation in the Gastrointestinal Tract

Sigurðsson¹,

Banič

Christenson

1996

Dig Surg

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Sepsis and multiple-organ failure (MOF) are associated with a prolonged stay and high mortality rate in surgical intensive-care units. In recent years the occurrence of MOF has been linked with previous hypoperfusion of the gut during a variety of critical conditions. In the present study, we focused on the blood flow pattern (rather than the quantity of flow) in the mucosal microcirculation of the gastrointestinal tract during surgery and hemorrhagic shock. In anesthetized pigs subjected to laparotomy and hemorrhage, mucosal blood flow was continuously recorded using multichannel laser Doppler flowmetry (LDF). During normovolemic conditions, flowmotion at a rate of 3-5 cycles per minute occurred in the gastric, jejunal and colonic mucosa in all the animals. The flowmotion disappeared during severe blood loss and during administration of catecholamines. These results suggest that flowmotion, as measured by LDF, is a normal phenomenon in the mucosa of the gastrointestinal tract, but is disrupted during shock. The physiological and clinical significance of these findings awaits further studies.

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