For the purpose of validating the effectiveness of the sliding base for reducing the seismic response, we first conducted a shaking table test of a full-scale two-story wooden frame. In addition, we also propose an evaluation formula for the coefficient of friction and confirm its effectivenes though a time history response analysis that simulates the test results using the calculated friction coefficient. The test results show that the sliding base reduces the maximum story drift angle to 1/100 rad or less even for the input of ground motion that causes severe damage to conventional wooden houses. The analysis results indicated that the test results could be simulated by the time history response analysis using the friction coefficient calculated by the proposed evaluation formula of the friction coefficient.