Prevention of Toxic-Allergic Reactions When Using Dentures and Devices

Abstract

Subject. Today, nanoparticles of chemical elements that make up the body are of particular interest. Such nanomaterials usually do not cause allergic reactions, they can potentially be broken down and removed from it, and, for example, drugs can be placed in the pores of these materials. At the Department of Prosthetic Dentistry of V.G. N.N. Burdenko together with Voronezh State University developed a polymer modified with nanosized silver particles, which was successfully tested on patients in the manufacture of removable plate prostheses. However, there is no data on the effect of this polymer in patients with complex jaw pathology in combination with somatic pathology, in which visible changes occur in the oral cavity. 
 Goal ― to consider the problem of prevention of toxic-allergic reactions when using complex-jaw prostheses and devices. To study the state of the oral microbiocenosis and the cytological characteristics of the mucous membrane in patients with apparatus bases made of a polymer modified with nanoscale silver. Materials and methods. 80 people were examined and 60 patients were treated for complete absence of teeth with various degrees of atrophy according to A.I.Doynikov (1967) I, II, III, IV, V, with a uniform quantitative distribution in groups. 
 Methodology. 80 people were examined and 60 patients were treated for complete absence of teeth with various degrees of atrophy according to A.I.Doynikov (1967) I, II, III, IV, V, with a uniform quantitative distribution in groups. 
 Results. The dynamics of the inflammatory processes of the mucous membrane of the prosthetic bed under the bases of removable jaw devices made by the known method and with bases from modified materials was studied. A complex of personalized prevention of complications associated with the action of basic polymers has been developed. 
 Conclusion. Obtained by analyzing the results of the study, it was possible to create, on the basis of the use of modified acrylic polymer as the material of the bases of removable prostheses and devices, a program for individual prevention of the inflammatory complications induced by them from the mucosa of the prosthetic bed, the efficiency level of which is at least 60 %. This predisposes to recommendations for the further implementation of the modified nanosilver acrylic polymer in practical dentistry.

Nanotechnology and Prosthetic Devices: Integrating Biomedicine and Materials Science for Enhanced Performance and Adaptability

“…However, potential risks related to nanomaterials must be carefully considered, including concerns about long-term biocompatibility and systemic effects. Certain nanoparticles' potential toxicity and accumulation in tissues raise questions about their safety over extended periods (Zotov et al, 2020). Moreover, the manufacturing complexity and cost of nanomaterials may impact the accessibility of advanced skin prosthetics for some patients.…”