1947
DOI: 10.1097/00000446-194710000-00007
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Prevention of Tuberculosis Among Students of Nursing

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1948
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Cited by 8 publications
(5 citation statements)
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“…A subset of healthy, immunocompetent individuals remain TST and IGRA negative despite persistent, high levels of exposure to Mtb 4,5 . Highly Mtb exposed but persistently TST and IGRA negative individuals have been described among health-care workers 6,7 , household contacts of TB cases 811 , and gold miners living and working in close quarters with individuals with active disease 12,13 . These individuals have been dubbed “resisters” related to their persistent ability to remain TST and IGRA negative 4,5 .…”
Section: Introductionmentioning
confidence: 99%
“…A subset of healthy, immunocompetent individuals remain TST and IGRA negative despite persistent, high levels of exposure to Mtb 4,5 . Highly Mtb exposed but persistently TST and IGRA negative individuals have been described among health-care workers 6,7 , household contacts of TB cases 811 , and gold miners living and working in close quarters with individuals with active disease 12,13 . These individuals have been dubbed “resisters” related to their persistent ability to remain TST and IGRA negative 4,5 .…”
Section: Introductionmentioning
confidence: 99%
“…This retracing study provides evidence that relative (and possibly absolute in some) resistance to latent M.tb infection as traditionally defined by the absence of positive TST or IGRA can be an additional outcome of M.tb exposure in TB-endemic settings. Historical studies suggested that resistance to M.tb infection may occur [19][20][21][22][23][24][25][26]. This is to our knowledge the first study to carefully characterize the LTBI status with 2 separate immunologic assays and multiple time points after long-term follow-up of persistently TST− M.tbexposed individuals.…”
Section: Discussionmentioning
confidence: 99%
“…In various plasma metabolites, the levels of 6 metabolites were significantly higher in nonconverters than in converters (P < 0.05). Among these metabolites, deoxycorticosterone acetate allowed M. tuberculosis-infected MDMs to remain in a metabolically active state and restrict M. tuberculosis growth by enhancing Siglec-14 The frequency of nonconverters within heavily exposed environments differs across different population studies since the defining features of resistance to M. tuberculosis infection are not well established (5,(37)(38)(39)(40). To avoid misclassification and determine the presence and prevalence of true nonconverters, we performed a longitudinal follow-up analysis.…”
Section: Discussionmentioning
confidence: 99%