Prevention of type 2 Diabetes Mellitus: Potential of pharmacological agents

Predictors of weight reduction and maintenance in a large cohort of overweight and obese adults in a community setting

“…Weight management is more challenging in obese patients with type 2 diabetes . In a meta‐analysis, Dansinger at el .…”

“…12 Weight management is more challenging in obese patients with type 2 diabetes. 9 In a meta-analysis, Dansinger at el. reported greater weight reductions in studies where diabetics were excluded from the cohort.…”

“…Excess body weight is associated with decreased longevity and quality of life and a variety of pathological conditions . Clinical trials have reported numerous short‐ and long‐term health benefits associated with weight loss . It is well established that achieving even a minimal goal of sustained weight loss of 5–10% can reduce or even eliminate overweight and obesity‐related disorders .…”

“…1,[4][5][6][7] Clinical trials have reported numerous short-and long-term health benefits associated with weight loss. 4,[8][9][10] It is well established that achieving even a minimal goal of sustained weight loss of 5-10% can reduce or even eliminate overweight and obesity-related disorders. 6 However, the goal of weight loss and its maintenance is mostly unachieved at both individual and public health levels.…”

“…In fact, to date, only few identified variables were found to significantly and positively predict successful weight reduction and its maintenance, including: continuous professional support, 1,8,10 adherence to physical active lifestyle 2,[10][11][12][13][14][15] and the presence of a medical trigger for weight loss. 8 Additional potential predictors of successful weight reduction outcome were identified; however, to date, there is inconsistency or lack of studies regarding the contribution and significance of these additional variables: gender, 1,9,[14][15][16][17] age, 4,9,[12][13][14]16,18 ethnicity, [11][12][13][14]16 socioeconomic status, 12,14 marital status, 14,18 baseline BMI, 1,11,13,16,17 smoking status, 6 blood glucose, 5 lipids, thyroid-stimulating hormone (TSH) levels, use of medications and blood pressure. 17 To date, most studies related to identifying predictors of weight reduction and maintenance were designed and followed in a clinical setting, which is less relevant to prolonged maintenance of weight reduction, mainly due to the high number of people who do not adhere to prolonged weight loss programs.…”