Prevention of UV radiation-induced cutaneous photoaging in mice by topical administration of patchouli oil

Lin, Rong-Feng; Feng, Xue-Xuan; Li, Chuwen; Zhang, Xiaojun; Yu, Xiu-Ting; Zhou, Jiuyao; Xie, Zhaoxiong; Xie, Yinfeng; Su, Zi‐Ren; Zhan, Janis Ya‐Xian

doi:10.1016/j.jep.2014.04.020

Cited by 53 publications

(41 citation statements)

References 36 publications

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“…In our test, UVB did induce significantly the production of IL-6 that is close to 150–200 pg/10 4 cells in cell culture tests, and the same tendency is also seen in animal models (Figure 3). Since IL-6 is involved in the regulation of MAPK signaling cascade and stimulates the production of MMPs which can cause fibrillar collagen breakdown and thus leads to premature skin damage [18, 19], it is suggested that CFE can lower IL-6 and make less dermal structural alterations in here.…”

Section: Resultsmentioning

confidence: 99%

Djulis (Chenopodium formosanum Koidz.) Water Extract and Its Bioactive Components Ameliorate Dermal Damage in UVB-Irradiated Skin Models

Hong

Huang

Liu

et al. 2016

BioMed Research International

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Dermal photoaging is a condition of skin suffering inappropriate ultraviolet (UV) exposure and exerts inflammation, tissue alterations, redness, swelling, and uncomfortable feelings. Djulis (Chenopodium formosanum Koidz.) is a cereal food and its antioxidant and pigment constituents may provide skin protection from photoaging, but it still lacks proved experiments. In this study, protective effects of djulis extract (CFE) on UVB-irradiated skin were explored. The results showed that HaCaT cells with 150 μg/mL CFE treatment had higher survival and less production of interleukin- (IL-) 6, matrix metalloprotease- (MMP-) 1, and reactive oxygen species (ROS) in UVB-irradiated conditions. Subsequently, in animal studies, mice supplemented with CFE (100 mg/kg BW) were under UVB irradiation and had thinner epidermis and lower IL-6 levels in skin layer. These data demonstrate that bioactive compounds possessing the potency of antiphotoaging exist in CFE. Following that, we found rutin and chlorogenic acid (10–100 μM) could significantly increase cell viability and decrease the production of IL-6 in UVB models. Additionally, djulis pigment-betanin has no effect of increasing cell viability in this study. Our findings suggest CFE can protect skin against UV-induced damage and this protection is mainly from contributions of rutin and chlorogenic acid.

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Section: Resultsmentioning

confidence: 99%

Djulis (Chenopodium formosanum Koidz.) Water Extract and Its Bioactive Components Ameliorate Dermal Damage in UVB-Irradiated Skin Models

Hong

Huang

Liu

et al. 2016

BioMed Research International

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“…PO was purchased from Nanhai Zhongnan Co., Ltd. (Foshan, China; Lot 140801) and its quality was confirmed by gas chromatography-flame ionization detection in a previous study by our group (11). Chloral hydrate, TNBS, formic acid and D,L-4-chlorophenylalanine were purchased from Sigma-Aldrich (Merck Millipore, Darmstadt, Germany).…”

Section: Animalsmentioning

confidence: 99%

Patchouli oil ameliorates acute colitis: A targeted metabolite analysis of 2,4,6-trinitrobenzenesulfonic acid-induced rats

Yang

Jiang

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. The incidence of inflammatory bowel disease (IBD), characterized by chronic, relapsing intestinal inflammation, has continually increased in recent years. A previous study by our group identified five potential metabolic markers possibly associated with the pathology of 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced IBD in rats. The present study aimed to examine the potential therapeutic effects of the essential oil of Pogostemon cablin (also known as patchouli; PO) on TNBS-induced rats and investigate the concomitant metabolic changes by targeting the previously identified potential markers. Pogostemon cablin is widely used to treat gastrointestinal diseases, including IBD, in China. The results of the present study showed that PO (270 mg/kg, rectal instillation) significantly alleviated colonic damage and reduced disease activity indicators and colonic myeloperoxidase in TNBS-induced rats. In addition, a targeted metabolic profiling study identified that four metabolites were elevated in the urine of the animals in the TNBS group, which were significantly inhibited by treatment with PO: Two tryptophan metabolites [4-(2-aminophenyl)-2,4-dioxobutanoic acid and 4,6-cihydroxyquinoline] and two gut microbial metabolites (phenylacetylglycine and p-cresol glucuronide). Taken together, these findings suggested that PO ameliorated the symptoms of TNBS-induced IBD and reversed the metabolic changes potentially associated with TNBS-induced IBD in rats.

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“…Recent studies have shown that AO contains antioxidants that can catalyze ROS into O 2 and H 2 O. [ ][ ] Hence, AO possesses both antioxidant and anti‐inflammatory effects, which are crucial to its anti‐photoaging effect.…”

Section: Discussionmentioning

confidence: 99%

“…[28] Thus, application of products with antioxidant effects will be valuable for preventing skin photoaging. Recent [30] Hence, AO possesses both antioxidant and anti-inflammatory effects, which are crucial to its anti-photoaging effect. In summary, our experimental findings demonstrate that AO could markedly inhibit UV-B-induced skin photoaging owing to its anti-inflammatory properties, thereby opening a new avenue for the clinical application of AO as a therapeutic and cosmetic product.…”

Section: Discussionmentioning

confidence: 99%

The Chemical Compositions of Angelica pubescens Oil and Its Prevention of UV‐B Radiation‐Induced Cutaneous Photoaging

Chen

Zhong

et al. 2018

Chemistry & Biodiversity

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Angelica pubescens, a plant of the family Umbelliferae, has been widely used as traditional Chinese medicine for the treatment of many diseases. However, there has been minimal modern research focused on the pharmacological activity of oils extracted from Angelica pubescens, in particular, the potential anti-photoaging effects. Therefore, in the present study, we analyzed the chemical composition of Angelica pubescens oil (AO) and evaluated its bioactivity against photoaging in ultraviolet (UV) -B radiation-induced hairless mice. Overall, we identified and analyzed 93 compounds from the AO by gas chromatography-mass spectrometry (GC/MS). The top ten compounds were as follows: osthole (44.608%), glutaric acid hexadecyl pent-4-en-1-yl ester (5.758%), α-bisabolol (3.795%), eugenol (3.637%), (Z)-docos-13-enamide (3.286%), (3S,3aR)-3-butyl-3a,4,5,6-tetrahydro-3H-2-benzofuran-1-one (3.043%), m-cresol (2.841%), trans-sesquisabinene hydrate (2.128%), 4-hydroxy-2-methylacetophenone (1.735%), and (Z)-9-pentadecenol (1.509%). Application of AO improved the condition of UV-B radiation-induced damaged skin, and the mechanism of action was found to be related to inhibition of the production of inflammatory cytokines. These results highlight the potential application of AO for the development of skin care products.

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Prevention of UV radiation-induced cutaneous photoaging in mice by topical administration of patchouli oil

Cited by 53 publications

References 36 publications

Djulis (Chenopodium formosanum Koidz.) Water Extract and Its Bioactive Components Ameliorate Dermal Damage in UVB-Irradiated Skin Models

Djulis (Chenopodium formosanum Koidz.) Water Extract and Its Bioactive Components Ameliorate Dermal Damage in UVB-Irradiated Skin Models

Patchouli oil ameliorates acute colitis: A targeted metabolite analysis of 2,4,6-trinitrobenzenesulfonic acid-induced rats

The Chemical Compositions of Angelica pubescens Oil and Its Prevention of UV‐B Radiation‐Induced Cutaneous Photoaging

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