Prevention of Venous Graft Sclerosis with Clopidogrel and Aspirin Combined with a Mesh Tubing in a Dog Model of Arteriovenous Bypass Grafting

Zurbrügg, H. R.; Musci, M.; Sänger, Sylvia; Gutersohn, A.; Mülling, Christoph; Wellnhofer, Ernst; Schaffner, Thomas; Hetzer, Roland

doi:10.1053/ejvs.2001.1472

Cited by 4 publications

(2 citation statements)

References 21 publications

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“…Despite the many naturally occurring canine conditions that could potentially benefit from anti‐platelet therapy, most published research in dogs has focused on the use of clopidogrel in experimental models such as prevention of coronary artery thrombus (Yao et al ., ; Hennan et al ., ), vascular injuries (Zurbrugg et al ., ), and cerebral infarcts (Christoforidis et al ., ). Using a canine model for carotid artery thrombosis, aspirin and clopidogrel used in combination with melagatran, a direct thrombin inhibitor, were effective at preventing arterial occlusion.…”

Section: Inhibitors Of Platelet Activationmentioning

confidence: 99%

Anti‐platelet therapy in small animal medicine

Thomason

Lunsford

Mackin

2016

Vet Pharm & Therapeutics

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Thromboembolism is a significant complication in many commonly encountered diseases, and can be a devastating sequel to otherwise treatable conditions. Platelets play an essential role in the hemostatic process and, consequently, are associated with thrombus formation. Platelets adhere to denuded vascular subendothelium, recruit additional platelets and cells, aggregate, and provide the catalytic surface for thrombin production and fibrin formation. Therapy to prevent unwanted thrombus formation and thromboembolic crises is essential in the management of hypercoagulable patients. Unfortunately, many of the medications used in veterinary medicine that inhibit or modulate coagulation factors, such as the heparins, are cost prohibitive, only effective when administered by injection or require frequent drug monitoring, and are therefore poor choices for long term at home therapy. While the role of the platelet in pathologic thrombus formation is not fully understood, veterinarians often resort to anti-platelet therapy in the management of patients at risk for thromboembolic complications, because many anti-platelet medications are inexpensive, require minimal drug monitoring, and can be given orally. The aim of this review is to discuss the anti-platelet therapies that are currently being used or being considered for use to inhibit platelet function and reduce thromboembolic complications in hypercoagulable dogs and cats.

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Section: Inhibitors Of Platelet Activationmentioning

confidence: 99%

Anti‐platelet therapy in small animal medicine

Thomason

Lunsford

Mackin

2016

Vet Pharm & Therapeutics

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“…Leider liegen keine Daten über Langzeitergebnisse nach Anwendungen des Biocompoundshunts ® vor. In der Kardiochirurgie bestehen weit größere Erfahrungen mit der Anwendung dieses Meshes [6,7]. Der relativ hohe Preis und die lange Operationszeit belasten die Methode.…”

Section: Folgerungenunclassified

Der Biocompoundshunt® als Therapiemöglichkeit bei Aneurysmata von Dialysefisteln - eine kritische Wertung

Dedow

Kaduk

2006

Zentralbl Chir

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We report our experiences with surgical repair of aneurysms of hemodialysis fistulas. After partial resection and suture of the aneurysm a perivascular metal mesh tubing (Biocompound Shunt) is applied to prevent the development of a new aneurysm. This method allows the use of the autologous vein for hemodialysis access for longer periods. In 6 patients treated in this way we found after a median period of 23 months a new dilatation of the vein of 10 up to 21 millimetres without stenosis, thrombosis or infection. All patients were satisfied with this type of surgery.

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Fehleranalyse bei Rezidiveingriffen im Unterschenkeltrifurkationsbereich

Hanzlick¹

2009

Berliner Gefäßchirurgische Reihe

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Prevention of Venous Graft Sclerosis with Clopidogrel and Aspirin Combined with a Mesh Tubing in a Dog Model of Arteriovenous Bypass Grafting

Abstract: in this dog model the sheathing of vein grafts effectively prevents FIMH following bypass surgery. Clopidogrel is effective in NVG.

Cited by 4 publications

References 21 publications

Anti‐platelet therapy in small animal medicine

Anti‐platelet therapy in small animal medicine

Der Biocompoundshunt® als Therapiemöglichkeit bei Aneurysmata von Dialysefisteln - eine kritische Wertung

Fehleranalyse bei Rezidiveingriffen im Unterschenkeltrifurkationsbereich

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