Prevention of Vitamin D deficiency in infancy: daily 400 IU vitamin D is sufficient

Mutlu, Gül Yeşiltepe; Kuşdal, Yusuf; Özsu, Elif; Çizmecioğlu, Filiz Mine; Hatun, Şükrü

doi:10.1186/1687-9856-2011-4

Cited by 38 publications

(46 citation statements)

References 20 publications

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“…But the reasons proposed by other studies, that boys tended to spend longer periods of time outdoors with less frequent use of sunscreen23-26), were not appropriate for our results. Our subjects were 1 to 6 months aged infants, who live indoors all day long, regardless of sex27). In this situation, this difference between two sex was so notable that it needs to recognize other influencing factor in the following study.…”

Section: Discussionmentioning

confidence: 98%

Vitamin D deficiency in infants aged 1 to 6 months

2013

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PurposeThe aim of this study was to recognize the state of vitamin D among healthy infants aged 1 to 6 months in South Korea, and also to identify the risk factors affecting the level of vitamin D.MethodsA total of 117 infants were enrolled in this study for 12 months, from March 1, 2011 to February 29, 2012. Serum levels of 25-hydroxyvitamin D (25[OH]D), calcium, phosphorus, and alkaline phosphatase were measured and data including birth weight, body weight, sex, feeding pattern, delivery mode, siblings and maternal age and occupation were collected. Data was mainly analyzed with independent t-test model.ResultsWe determined that the prevalence of vitamin D deficiency (serum 25[OH]D<20 ng/mL [50 mmol/L]) was 48.7% in the population investigated. Particularly in breastfed infants, the prevalence of vitamin D deficiency was strikingly high (90.4%). The mean serum level of 25(OH)D in breastfed infants was lower than that of formula fed infants (9.35 ng/mL vs. 28.79 ng/mL). Also female infants showed lower mean serum level of 25(OH)D than male. Mean serum values of calcium and phosphorus had positive correlation with vitamin D state (P<0.001).ConclusionVitamin D deficiency was found to be very common in infants aged 1 to 6 months in South Korea, and breast feeding was the most critical risk factor of vitamin D deficiency. Therefore we suggest to start vitamin D supplementation in South Korea, as soon as possible, to all infants, including breastfed and female infants.

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Section: Discussionmentioning

confidence: 98%

Vitamin D deficiency in infants aged 1 to 6 months

2013

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“…In this program, the recommended daily vitamin D dose is 400 IU, which is compatible with the “Institute of Medicine (IOM) Committee’s http://www.nationalacademies.org/hmd/ 2011 Report on Dietary Reference Intakes for Calcium and Vitamin D”. This dose was chosen also because a daily 400 U supplementation of vitamin D was shown to be adequate to provide a serum 25(OH)D level >15 ng/mL in >90% of all infants (7,8). In a large scaled survey study by the Ministry of Health to evaluate the success of the nationwide program, it was shown that of 2504 infants aged between 6 and 17 months, serum 25(OH)D level was >15 ng/mL in 73.6% (9).…”

Section: Discussionmentioning

confidence: 99%

Attitudes of Pediatricians Regarding Prevention and Treatment of Vitamin D Deficiency

Karabulut¹,

Hatun

Bıdecı³

et al. 2016

Jcrpe

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To determine the adherence of pediatricians to the nationwide ‘Vitamin D Prophylaxis Program’ and to evaluate their attitudes about vitamin D intake. The study was conducted using the Turkish National Pediatrics Association network. The pediatricians were asked to respond to an online questionnaire that included five questions on ‘What dose of vitamin D they recommend for supplementation?’, ‘At what age they start vitamin D supplementation?’, ‘Supplementation method’, ‘Clichés and truths about vitamin D’, and ‘High-dose vitamin D therapy indications’. Responses of 167 pediatricians were evaluated in this study. 75.5% of pediatricians indicated that they recommended vitamin D supplementation in a daily dose of 400 IU. 47.1% started vitamin D supplementation by the end of the 2nd week. 7.83% of pediatricians suggested doubling the daily dose of vitamin D supplementation in infants with delayed tooth eruption, 19.9% suggested immediate cessation of vitamin D supplementation in infants with small anterior fontanels. This study showed that the majority of the pediatricians still prescribe vitamin D prophylaxis late, recommend high doses of vitamin D in cases of delayed tooth eruption, and think that low serum 25-hydroxy vitamin D level regardless of alkaline or phosphatase parathyroid hormone measurement is an indication for high-dose vitamin D (stoss) therapy. These results suggest a need for new training programs focusing on vitamin D supplementation.

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“…In another study, similar to our results, it was found that the frequencies of vitamin D deficiency and insufficiency in infants aged 3-18 months were 4.7 % and 7.1 %, respectively. 16 However, in a study conducted in our region in healthy children 400 IU/day vitamin D supplementation dose in the first year was insufficient; 25(OH)D levels in 30 % of the children aged 12-24 months were reported to be below 15 ng/mL. 17 The results of that study were quite different from our results, possibly due to the fact that the children included in that study were only fed with breast milk and did not receive formula.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D levels of 12-24-month-old healthy children in Turkey who received vitamin D supplementation until the age of one year

Elitok

Bülbül

et al. 2020

Arch Argent Pediat

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Introduction. The aim of this study was to evaluate vitamin D levels between 12-24 monthold healthy children supplemented with vitamin D (400 IU/day) during the first year. Methods. Descriptive-sectional study conducted between June 2015, and May 2016, in Istanbul (latitude 41ºN). Children aged 12-24 months followed up by the well-child clinic who had vitamin D supplementation in the first year were included in the study. The levels of calcium, phosphorus, alkaline phosphatase, parathyroid hormone and 25-hydroxyvitamin D [25(OH)D] were measured. Vitamin D status was defined as >20 ng/mL: sufficiency, 15-20 ng/mL: insufficiency and <15 ng/mL: deficiency. Results. The study was completed with 197 children. 26.9 % of children (n = 53) went on receiving supplementation after one year (mean dose 491 ± 267 IU/day). The mean 25(OH)D level was 38.0 ± 13.9 ng/mL. It was found that regular vitamin D intake under one year of age (p = 0.008) and continued support after one year of age (p = 0.042) increased level of 25(OH)D in children aged 12-24 months. Vitamin D deficiency was found in 4.1 % and vitamin D insufficiency in 7.1 %. Mother's education (p = 0.009) and use of formula (p = 0.012) were protective factors in relation to development of vitamin D deficiency or insufficiency. Conclusions. The level of 25(OH)D was sufficient in 88.8 % of children aged 12-24 months receiving 400 IU/day vitamin D supplementation in the first year. Vitamin D supplementation could not be required in healthy children aged 12-24 months who received properly vitamin D supplementation in the first year.

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Prevention of Vitamin D deficiency in infancy: daily 400 IU vitamin D is sufficient

Cited by 38 publications

References 20 publications

Vitamin D deficiency in infants aged 1 to 6 months

Vitamin D deficiency in infants aged 1 to 6 months

Attitudes of Pediatricians Regarding Prevention and Treatment of Vitamin D Deficiency

Vitamin D levels of 12-24-month-old healthy children in Turkey who received vitamin D supplementation until the age of one year

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