Prevention of Vomiting After Tonsillectomy in Children: Granisetron Versus Ramosetron

Abstract

Ramosetron is a better antiemetic than granisetron for the long-term prevention of postoperative vomiting in children undergoing general anesthesia for tonsillectomy.

Current Management of Vomiting After Tonsillectomy in Children

“…at the end of surgery, for the prevention of POV in children who underwent tonsillectomy with or without adenoidectomy. In this clinical trial, the antiemetic efficacy of ramosetron was more effective than granisetron for preventing POV during 0-24 h after anesthesia, and ramosetron was more effective than granisetron in decreasing POV during 24-48 h after anesthesia (7% versus 29%) [52]. A dose-ranging study comparing 3 doses (3, 6, and 12 mcg kg -1 ) of ramosetron with placebo, given i.v.…”

Current Review of Ramosetron in the Prevention of Postoperative Nausea and Vomiting

“…In another study, ramosetron 6 mcg kg -1 , compared with granisetron 40 mcg kg -1 , was effective for the prevention of POV during 24-48 h after tonsillectomy in 90 children (43 boys and 47 girls). The efficacy of ramosetron was the same as that of granisetron for the prophylaxis against POV during 0-24 h after anesthesia in this population [33].…”

“…For pediatric patients, clinically serious AEs, including excessive sedation and extrapyramidal symptoms, attributable to ramosetron were not observed in children [27][28][29][30] . The most common AE was not presented in these clinical studies [30][31][32][33].…”

“…A number of clinical studies have shown that prophylactic ramosetron administered IV at the end of surgical procedure reduces the incidence of POV after strabismus surgery and tonsillectomy in children [30][31][32][33]. In a randomized, double-blind, placebo-controlled study, Fujii et al evaluated the efficacy of ramosetron at 3 different doses (3 mcg kg 1 , 6 mcg kg 1 , and 12 mcg kg 1 ) for preventing POV in 80 children (38 boys and 42 girls) undergoing strabismus surgery.…”

“…No data on cardiac dysrhythmias after ramosetron administration were presented in these selected articles [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33]. Thus, ramosetron is relatively free of AEs in adults and children.…”