Prevention of Wound Infection in Abdominal Operations by Peroperative Antibiotics or Povidone- Iodine

Galland, R. B.; Mosley, J G; Saunders, James H.; Darrell, J. H.

doi:10.1016/s0140-6736(77)91880-3

Cited by 58 publications

(25 citation statements)

References 15 publications

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“…A second article was excluded due to lack of a control group, thus not meeting our criteria for a RCT [17]. Three articles were excluded for enrolling both elective and emergent abdominal operations, for which the data could not be differentiated [1, 11, 18]. Harihara et al used PVI topically on the skin rather than the subcutaneous tissue [19].…”

Section: Resultsmentioning

confidence: 99%

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Povidone-Iodine Irrigation of Subcutaneous Tissues May Decrease Surgical Site Infections in Elective Colorectal Operations: A Systematic Review

et al. 2011

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BackgroundPostoperative wound infection is the most common complication following abdominal surgery and leads to delayed wound healing, prolonged hospital length of stay (LOS), and causes morbidity. Povidone-Iodine (PVI) is a broad-spectrum anti-septic and disinfectant solution, and can be used intra-operatively to irrigate subcutaneous tissues prior to abdominal skin closure. We systematically reviewed the literature regarding the efficacy of intra-operative PVI irrigation of subcutaneous tissues following elective colorectal surgery.MethodsA comprehensive search of electronic databases and various grey literature sources was completed. Unpublished and non-English-language results were included. All clinical controlled trials involving PVI solution in adult colorectal surgery were included. Two independent reviewers assessed the studies for relevance, inclusion, methodological quality and extracted data from the full versions of the manuscripts. Disagreements were resolved by re-extraction or third party adjudication. Data for dichotomous outcomes are reported as relative risks (RR) with 95% confidence intervals (CI). For continuous data, mean differences (MD) are reported with 95% CIs.ResultsFive randomized controlled trials (RCTs) involving 205 patients comparing PVI solution or spray to a control group following abdominal fascial closure in elective colorectal or clean-contaminated operations were identified. Pooled results demonstrated a reduction in surgical site infection for patients treated with PVI (RR = 1.97; 95% CI: 1.22 to 3.17) compared to controls.ConclusionsIrrigation of subcutaneous tissues with PVI following abdominal fascial closure is associated with a reduced incidence of surgical site infection. Due to the small number of included trials and patients, additional robust randomized trials are needed.

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Section: Resultsmentioning

confidence: 99%

“…Postoperative wound infection is the most common complication following abdominal operations [1]. Surgical site infections (SSIs) account for 40% of nosocomial infections among surgical patients [2].…”

Section: Introductionmentioning

confidence: 99%

Povidone-Iodine Irrigation of Subcutaneous Tissues May Decrease Surgical Site Infections in Elective Colorectal Operations: A Systematic Review

et al. 2011

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“…Three of these were excluded: a congress abstract18 later published in an article included in the meta‐analysis, one lacking the required data19, and one that compared both shaving and irrigation but without detailed data20. Fifteen of the remaining studies which were graded as having a low risk of bias were included in the main analysis21–35, and nine graded as having a moderate risk of bias were included only in the sensitivity analysis36–44. Owing to the nature of irrigation, blinding of surgeons was not possible, but wound assessment was evaluated blind in seven of the 15 articles included in the main analysis.…”

Section: Resultsmentioning

confidence: 99%

Meta-analysis of intraoperative povidone–iodine application to prevent surgical-site infection

Fournel¹,

Tiv²,

Soulias³

et al. 2010

British Journal of Surgery

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“…form part of the commensal flora of the mouth, gut and female genital tract. Bacteroides has been increasingly recognized as a pathogen in wounds and after abdominal surgery where contamination with gut organisms is the probable source of infection (Finegold, 1974;Feathers et al, 1977;Griffiths et al, 1976;Galland et al, 1977). Fusobacterium is occasionally pathogenic in these situations, but its role in causing a wide variety of necrotic lesions (necrobacillosis) in man (e.g.…”

Section: Discussionmentioning

confidence: 99%

“…At post-mortem examination, the right cerebral hemisphere was covered with foul-smelling, thick, yellowish pus which was mainly in the subdural space but also in the subarachnoid space (Fig. 1) (Finegold, 1974;Feathers et al, 1977;Griffiths et al, 1976;Galland et al, 1977). Fusobacterium is occasionally pathogenic in these situations, but its role in causing a wide variety of necrotic lesions (necrobacillosis) in man (e.g.…”

Section: Case Reportmentioning

confidence: 99%

Primary meningitis caused by Bacteroides fragilis and Fusobacterium necrophorum

Islam

Shneerson

1980

Postgraduate Medical Journal

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Summary A fatal case of meningitis due to Bacteroides fragilis and Fusobacterium necrophorum is reported. This appears to be the first case in which meningitis due to these organisms was not secondary to a disease elsewhere in the body. The organisms are difficult to culture and strict anaerobic methods should be used whenever they are suspected. Intravenous metronidazole is probably the antibiotic of choice.

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Prevention of Wound Infection in Abdominal Operations by Peroperative Antibiotics or Povidone- Iodine

Cited by 58 publications

References 15 publications

Povidone-Iodine Irrigation of Subcutaneous Tissues May Decrease Surgical Site Infections in Elective Colorectal Operations: A Systematic Review

Povidone-Iodine Irrigation of Subcutaneous Tissues May Decrease Surgical Site Infections in Elective Colorectal Operations: A Systematic Review

Meta-analysis of intraoperative povidone–iodine application to prevent surgical-site infection

Primary meningitis caused by Bacteroides fragilis and Fusobacterium necrophorum

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