Prevention properties on cerebral ischemia reperfusion of medicine food homologous Dioscorea yam-derived diosgenin based on mediation of potential targets

Zhang, Xinxin; Wang, Xingbin; Xue, Zhaowei; Zhan, Guanqun; Ito, Yoichiro; Guo, Zengjun

doi:10.1016/j.foodchem.2020.128672

Cited by 18 publications

(8 citation statements)

References 40 publications

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“…In another study, diosgenin was evaluated against cerebral ischemia-reperfusion injury through in silico (proteome dynamic approach), in vitro, and in vivo methods. The authors investigated 5043 regulatory proteins from the brain samples and different signaling pathways [ 77 ]. Screening of small molecules for targeting the fungal virulence factors without any effect on viability was conducted by Aaron and the group [ 78 ].…”

Section: Pharmacological Properties Of Diosgenin: Underlying Molecula...mentioning

confidence: 99%

Diosgenin: An Updated Pharmacological Review and Therapeutic Perspectives

Semwal

Painuli

Abu-Izneid

et al. 2022

Oxidative Medicine and Cellular Longevity

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Plants including Rhizoma polgonati, Smilax china, and Trigonella foenum-graecum contain a lot of diosgenin, a steroidal sapogenin. This bioactive phytochemical has shown high potential and interest in the treatment of various disorders such as cancer, diabetes, arthritis, asthma, and cardiovascular disease, in addition to being an important starting material for the preparation of several steroidal drugs in the pharmaceutical industry. This review aims to provide an overview of the in vitro, in vivo, and clinical studies reporting the diosgenin’s pharmacological effects and to discuss the safety issues. Preclinical studies have shown promising effects on cancer, neuroprotection, atherosclerosis, asthma, bone health, and other pathologies. Clinical investigations have demonstrated diosgenin’s nontoxic nature and promising benefits on cognitive function and menopause. However, further well-designed clinical trials are needed to address the other effects seen in preclinical studies, as well as a better knowledge of the diosgenin’s safety profile.

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Section: Pharmacological Properties Of Diosgenin: Underlying Molecula...mentioning

confidence: 99%

Diosgenin: An Updated Pharmacological Review and Therapeutic Perspectives

Semwal

Painuli

Abu-Izneid

et al. 2022

Oxidative Medicine and Cellular Longevity

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show abstract

“…Strokes can be divided into hemorrhagic stroke and ischemic stroke, with the latter accounting for about 80 % of all cases [ 1 ]. The most frequent reason of ischemic stroke is a sudden thrombus formation leading to vascular occlusion, which blocks blood flow and interrupts the glucose and oxygen required to maintain brain metabolism [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…The most frequent reason of ischemic stroke is a sudden thrombus formation leading to vascular occlusion, which blocks blood flow and interrupts the glucose and oxygen required to maintain brain metabolism [ 2 , 3 ]. The restoration of cerebral blood flow after stroke can rescue ischemia neuronal damage, but it can also cause a cascade of neurological impairments known as cerebral ischemia/reperfusion injury (CIRI) [ 1 , 4 ]. The mechanisms leading to CIRI are complex and multifactorial, including disturbances in energy metabolism, free radical damage, inflammatory response, and induction of apoptosis [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Ginsenoside Rg1 attenuates cerebral ischemia-reperfusion injury due to inhibition of NOX2-mediated calcium homeostasis dysregulation in mice

Han

Yang

et al. 2022

Journal of Ginseng Research

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“…In recent years, with the improvement of public health awareness, people have paid increasing attention to the prevention and treatment of chronic diseases through diet, such as a "low-, fermentable oligo-, and di-, monosaccharides and polyols" diet, Mediterranean diet, a low-lactose diet, and medicinal food herb diet [8][9][10][11]. The concept of medicine food homology (MFH) originally came from the (Huangdi's) Internal Classic in ancient China, which means that Chinese medicine and food are of the same origin, and, thus, they can be used as food and administered to patients as medication to regulate the human body's metabolic disturbances or imbalances [11,12].…”

Section: Introductionmentioning

confidence: 99%

Medicine-Food Herbs against Alzheimer’s Disease: A Review of Their Traditional Functional Features, Substance Basis, Clinical Practices and Mechanisms of Action

et al. 2022

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Alzheimer’s disease (AD) is a progressive, neurodegenerative disorder that currently has reached epidemic proportions among elderly populations around the world. In China, available traditional Chinese medicines (TCMs) that organically combine functional foods with medicinal values are named “Medicine Food Homology (MFH)”. In this review, we focused on MFH varieties for their traditional functional features, substance bases, clinical uses, and mechanisms of action (MOAs) for AD prevention and treatment. We consider the antiAD active constituents from MFH species, their effects on in vitro/in vivo AD models, and their drug targets and signal pathways by summing up the literature via a systematic electronic search (SciFinder, PubMed, and Web of Science). In this paper, several MFH plant sources are discussed in detail from in vitro/in vivo models and methods, to MOAs. We found that most of the MFH varieties exert neuroprotective effects and ameliorate cognitive impairments by inhibiting neuropathological signs (Aβ-induced toxicity, amyloid precursor protein, and phosphorylated Tau immunoreactivity), including anti-inflammation, antioxidative stress, antiautophagy, and antiapoptosis, etc. Indeed, some MFH substances and their related phytochemicals have a broad spectrum of activities, so they are superior to simple single-target drugs in treating chronic diseases. This review can provide significant guidance for people’s healthy lifestyles and drug development for AD prevention and treatment.

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Prevention properties on cerebral ischemia reperfusion of medicine food homologous Dioscorea yam-derived diosgenin based on mediation of potential targets

Cited by 18 publications

References 40 publications

Diosgenin: An Updated Pharmacological Review and Therapeutic Perspectives

Diosgenin: An Updated Pharmacological Review and Therapeutic Perspectives

Ginsenoside Rg1 attenuates cerebral ischemia-reperfusion injury due to inhibition of NOX2-mediated calcium homeostasis dysregulation in mice

Medicine-Food Herbs against Alzheimer’s Disease: A Review of Their Traditional Functional Features, Substance Basis, Clinical Practices and Mechanisms of Action

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