Prevention strategies for sexually transmitted infections, HIV, and viral hepatitis in Europe

Gökengin, Deniz; Noori, Teymur; Alemany, Andrea; Bienkowski, Carlo; Liegon, Geoffroy; İnkaya, Ahmet Çağkan; Carrillo, Jorge; Stary, Georg; Knapp, Katja; Mitja, Oriol; Molina, Jean-Michel

doi:10.1016/j.lanepe.2023.100738

Cited by 19 publications

(13 citation statements)

References 109 publications

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“…This model could also be useful to study how to deliver GT-CuO NPs to patients with gonorrhea. It is possible that such nanoparticles could be embedded in slow-release intravaginal rings to treat women with mucosal infection, and further in vivo studies on delivery are warranted. An examination of the potential of gonococci to build resistance to the CuO NPs would be necessary, for example, using the hollow fiber model .…”

Section: Discussionmentioning

confidence: 99%

In Vitro Bactericidal Activity of Biogenic Copper Oxide Nanoparticles for Neisseria gonorrhoeae with Enhanced Compatibility for Human Cells

Santana,

Armentano,

Ferreira

et al. 2024

ACS Appl. Mater. Interfaces

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Resistance to antibiotics and antimicrobial compounds is a significant problem for human and animal health globally. The development and introduction of new antimicrobial compounds are urgently needed, and copper oxide nanoparticles (CuO NPs) have found widespread application across various sectors including biomedicine, pharmacy, catalysis, cosmetics, and many others. What makes them particularly attractive is the possibility of their synthesis through biogenic routes. In this study, we synthesized biogenic green tea (GT, Camellia sinensis)-derived CuO NPs (GT CuO NPs) and examined their biophysical properties, in vitro toxicity for mammalian cells in culture, and then tested them against Neisseria gonorrhoeae, an exemplar Gram-negative bacterium from the World Health Organization's Priority Pathogen List. We compared our synthesized GT CuOP NPs with commercial CuO NPs (Com CuO NPs). Com CuO NPs were significantly more cytotoxic to mammalian cells (IC50 of 7.32 μg/mL) than GT CuO NPs (IC50 of 106.1 μg/mL). GT CuO NPs showed no significant increase in bax, bcl2, il6, and il1β mRNA expression from mammalian cells, whereas there were notable rises after treatment with Com CuO NPs. GT-CuO NPs required concentrations of 0.625 and 3.125 μg/mL to kill 50 and 100% of bacteria, respectively, whereas Com-CuO NPs needed concentrations of 15.625 and 30 μg/mL to kill 50 and 100% of bacteria, and the antibiotic ceftriaxone killed 50 and 100% with 3.125 and 30 μg/mL. Gonococci could be killed within 30 min of exposure to GT CuO NPs and the NPs could kill up to 10 7 within 1 h. In summary, this is the first report to our knowledge that describes the bioactivity of biogenic CuO NPs against N. gonorrhoeae. Our data suggest that biogenic nanoparticle synthesis has significant advantages over traditional chemical routes of synthesis and highlights the potential of GT-CuO NPs in addressing the challenges posed by multidrug-resistant Neisseria gonorrhoeae infections.

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Section: Discussionmentioning

confidence: 99%

In Vitro Bactericidal Activity of Biogenic Copper Oxide Nanoparticles for Neisseria gonorrhoeae with Enhanced Compatibility for Human Cells

Santana,

Armentano,

Ferreira

et al. 2024

ACS Appl. Mater. Interfaces

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“…The substantial decline in infection rates can be plausibly attributed to the minimally invasive characteristics of UMA. 12,13 This technique minimizes the patient's exposure to potential infectious agents by causing less tissue trauma and requiring a shorter operative time. 14 It is noteworthy that although UMA resulted in a shorter duration of the procedure and has a shorter hospital stay, these reductions failed to achieve statistical significance.…”

Section: Discussionmentioning

confidence: 99%

“…Ultrasound‐guided microwave ablation is the promising alternative to conventional surgery for the treatment of varicose veins, particularly in reducing postoperative wound infection rates, according to the findings of our study. The substantial decline in infection rates can be plausibly attributed to the minimally invasive characteristics of UMA 12,13 . This technique minimizes the patient's exposure to potential infectious agents by causing less tissue trauma and requiring a shorter operative time 14…”

Section: Discussionmentioning

confidence: 99%

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Assessing postoperative wound infection rates in ultrasound‐guided microwave ablation versus conventional surgery for varicose veins

Wu,

Lu,

Cheng

et al. 2023

International Wound Journal

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Varicose veins are the prevalent vascular disorder that has conventionally been managed via risky postoperative wound infections and conventional surgery. While ultrasound‐guided microwave ablation (UMA) has gained attention as a minimally invasive alternative, there is still a lack of research examining its comparative effectiveness. A prospective comparative investigation was undertaken in the Zhejiang region of China from January to November 2023, involving 140 patients who had received the diagnosis of primary varicose veins. An equal number of 70 patients underwent UMA and conventional surgery. Exclusion criteria for the study encompassed adult patients aged 18–65, with the exception of those who had undergone prior venous surgery, deep vein thrombosis or peripheral arterial disease. The demographical characteristics, procedural details and complication profiles of patients who developed postoperative wound infections within 30 days were analysed statistically. The outcomes demonstrated that postoperative wound infections were significantly diminished (5.7%) with UMA in comparison to conventional surgery (17.1%). In addition, the average duration of procedures and length of hospital stay for UMA patients were both reduced, although neither of these differences was found to be statistically significant (p > 0.05). Infection management, age and gender distribution of varicose veins were comparable between the two groups (p > 0.05). A significant inverse correlation was observed between the severity of varicose veins and postoperative outcomes, as determined by the regression analysis (p < 0.05). Using UMA to treat varicose veins showed promise as an alternative to conventional surgery, specifically in minimizing the incidence of postoperative wound infections. Additional research and clinical consideration are needed regarding the potential transition toward minimally invasive techniques in treatment of varicose veins, as suggested by these results.

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“…Infection with STIs can result in a range of associated complications if left untreated [ 7 , 8 ]. These include cervical cancer, infertility, chronic pain, and heightened neonatal morbidity and mortality [ 2 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Estimates of the incidence, prevalence, and factors associated with common sexually transmitted infections among Lebanese women

Chemaitelly,

Finan,

Racoubian

et al. 2024

PLoS ONE

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Background We analyzed the prevalence of active infection with common curable sexually transmitted infections (STIs) including N. gonorrhea, C. trachomatis, T. vaginalis, and T. pallidum, as well as active infection with HPV, herpes simplex virus types I (HSV-1) and II (HSV-2), M. hominis, M. genitalium, C. albicans, and Ureaplasma in 351 Lebanese women. Methods A cross-sectional study, involving 351 sexually active women, 40 years or younger, who were recruited from outpatient Obstetrics and Gynecology clinic attendees between September 2016 and November 2017. Results The prevalence of active infection was low at 0.3% for N. gonorrhea, 0.6% for HSV-2, 2.8% for C. trachomatis, and 2.9% for any curable STIs. Prevalence of active HPV infection was high assessed at 15.7% for high-risk and 12.2% for low-risk genotypes. Furthermore, the prevalence was 2.0% for M. genitalium, 6.8% for ureaplasma, 13.7% for Candida albicans, and 20.5% for M. hominis. No active infections with T. vaginalis, T. pallidum, or HSV-1 were observed. Significant age differences were noted in the prevalence of high-risk and low-risk HPV genotypes, but no such differences were noted in the prevalence of other infections. No appreciable variations were identified in the prevalence of key STIs based on smoking, marital status, or the number of sexual partners. Conclusions The study documented active infection with substantial prevalence for multiple STIs among women attending outpatient gynecology and obstetrics clinics in Lebanon. These findings underscore the importance of strengthening STI surveillance, linkage to care, and prevention interventions in reducing STI incidence among women.

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Prevention strategies for sexually transmitted infections, HIV, and viral hepatitis in Europe

Cited by 19 publications

References 109 publications

In Vitro Bactericidal Activity of Biogenic Copper Oxide Nanoparticles for Neisseria gonorrhoeae with Enhanced Compatibility for Human Cells

In Vitro Bactericidal Activity of Biogenic Copper Oxide Nanoparticles for Neisseria gonorrhoeae with Enhanced Compatibility for Human Cells

Assessing postoperative wound infection rates in ultrasound‐guided microwave ablation versus conventional surgery for varicose veins

Estimates of the incidence, prevalence, and factors associated with common sexually transmitted infections among Lebanese women

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