Preventive Administration of Juanbi Capsules () for Knee Osteoarthritis: Effects on Serum MMP-2 and MMP-9 levels and Cartilage Repair

Pan, Yuan; Yu, Hongbo; Zhou, Haizhe; Zhu, Chao; Qu, Qiang; Liu, Deyu

doi:10.1016/s0254-6272(12)60014-4

Cited by 8 publications

(10 citation statements)

References 7 publications

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“…Juanbi capsule is a Chinese medicine for preventing OA. It has been found that Juanbi capsule in vivo can effectively protect cartilage and significantly decrease serum MMP-2 and MMP-9 levels [ 64 ]. Sinomenine, an alkaloid isolated from Sinomenium acutum , can dose-dependently inhibit the release of glycosaminoglycans (GAG) and the expression of MMP-13 and caspase 3 and enhance the activity of TIMP-1, leading to prevention of DNA fragment and cell apoptosis in chondrocytes [ 65 ].…”

Section: Anticatabolic Activity Of Tcmmentioning

confidence: 99%

Insights into the Action Mechanisms of Traditional Chinese Medicine in Osteoarthritis

Liu

Shi

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Osteoarthritis (OA) is a chronic degenerative joint disease characterized by articular cartilage destruction, synovial inflammation, and osteophyte formation. No effective treatments are available. The current pharmacological medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) and analgesics, accompanied by possible adverse effects, might ameliorate OA symptoms. But they do not arrest the progression of OA. Traditional Chinese medicine (TCM) provides medical value by modification of disease and symptoms in OA. Valuable work on exploring TCM merits for OA patients has been investigated using modern technologies, although the complicated interacting network among the numerous components indicates the uncertainty of target specification. This review will provide an overview of the action mechanism of TCM in the last 5 years, discussing the TCM activities of anti-inflammation, antiapoptosis, antioxidation, anticatabolism, and proliferation in OA. TCM is a proposed medical option for OA treatment.

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Section: Anticatabolic Activity Of Tcmmentioning

confidence: 99%

Insights into the Action Mechanisms of Traditional Chinese Medicine in Osteoarthritis

Liu

Shi

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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“…For example, Zhu et al described protective activity for cartilage via reducing expressions of MMP-3, ADAMTS-4 and elevating TIMP-1, TIMP-3 with the TCM Sanmiao formulae which was administered to rat model induced by potassium oxonate and cold bath ( Zhu et al, 2016 ). Yuan et al (2011) reported similar benefits with Juanbi capsules in rabbits subjected to plaster cast fixation. In vitro models, Monotropein exhibited anti-apoptotic and anti-catabolic effects on rat OA chondrocytes treated by IL-β ( Wang et al, 2014 ).…”

Section: Discussionmentioning

confidence: 68%

Yougui Pills Attenuate Cartilage Degeneration via Activation of TGF-β/Smad Signaling in Chondrocyte of Osteoarthritic Mouse Model

et al. 2017

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Yougui pills (YGPs) have been used for centuries in the treatment of Chinese patients with Kidney-Yang Deficiency Syndrome. Despite the fact that the efficiency of YGPs on treating osteoarthritis has been verified in clinic, the underlying mechanisms are not totally understood. The present study observes the therapeutic role of YGPs and mechanisms underlying its chondroprotective action in osteoarthritic cartilage. To evaluate the chondroprotective effects of YGPs, we examined the impact of orally administered YGPs in a model of destabilization of the medial meniscus (DMM). Male C57BL/6J mice were provided a daily treatment of YGPs and a DMM surgery was performed on the right knee. At 12 weeks post-surgery, the joints were harvested for tissue analyses, including histomorphometry, OARSI scoring, micro-CT and immunohistochemistry for COL-2, MMP-13 and pSMAD-2. We also performed the relative experiments mentioned above in mice with Tgfbr2 conditional knockout (TGF-βRIICol2ER mice) in articular cartilage. To evaluate the safety of YGPs, hematology was determined in each group. Amelioration of cartilage degradation was observed in the YGPs group, with increases in cartilage area and thickness, proteoglycan matrix, and decreases in OARSI score at 12 weeks post surgery. In addition, reduced BV/TV and Tb. Th, and elevated Tb. Sp were observed in DMM-induced mice followed by YGPs treatment. Moreover, the preservation of cartilage correlated with reduced MMP-13, and elevated COL-2 and pSMAD-2 protein expressional levels were also revealed in DMM-induced mice treated with YGPs. Similarly, TGF-βRIICol2ER mice exhibited significant OA-like phenotype. However, no significant difference in cartilage structure was observed in TGF-βRIICol2ER mice after YGPs treatment. Interestingly, no obvious adverse effects were observed in mice from each group based on the hematologic analyses. These findings suggested that YGPs could inhibit cartilage degradation through enhancing TGF-β/Smad signaling activation, and be considered a good option for the treatment of osteoarthritis.

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“…At present, the ndings of most animal studies have con rmed the bene ts of JBT in improving arthritis and synovitis [41][42][43]. Signi cant reductions in the serum levels of MMP-2 and MMP-9 indicate that JBT has a role to play in preventing osteoarthritis [41].…”

Section: Discussionmentioning

confidence: 99%

Assessing the Efficacy of Chinese Herbal Medicine for Dialysis-related Myofascial Pain in the Fistula Arm: Study Protocol for a Pilot Randomized Trial

Hsu¹,

Ng²,

Lee³

et al. 2021

Preprint

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BackgroundDialysis-related myofascial pain in hemodialysis (HD) patients is an important issue that is associated with many other psychosomatic problems. Effective interventions are required to alleviate pain in this group. Chinese herbal medicine (CHM) may be a potential therapeutic treatment to reduce pain. The aim of this study is to evaluate the effect of a CHM formula intervention on pain intensity, daily function, quality of life, and safety among patients receiving HD in a dialysis center within a southern Taiwan context. MethodsThis will be a randomized, open label, cross-over trial with two parallel groups in a pre- and post-test study. Forty patients with myofascial pain related to their arteriovenous fistula in the arm during regular HD sessions will be recruited. Participants will receive 4 weeks of treatment with Juan Bi Tang (JBT) and 4 weeks of no treatment in a random order, separated by a washout period of 2 weeks. Treatment doses (3 g JBT) will be consumed thrice daily. The primary outcome measure will be the Kidney Disease Quality of Life 36-Item Short-Form Survey. Secondary outcomes will include the Fugl-Meyer Assessment–arm, Visual Analogue Scale of pain, and grip strength. Outcomes will be collected before and after each intervention, for a total of four times per participant. The safety evaluation will focus on adverse events. DiscussionThis study will be the first to use CHM to treat patients receiving HD with dialysis-related myofascial pain in their fistula arm and to perform a complete assessment of the treatment, including records of quality of life, arm function and muscle power, severity of pain, and safety. The results of the study will provide convincing evidence on the use of JBT as an adjuvant treatment for dialysis-related myofascial pain. TRIAL REGISTRATION:Clinicaltrials.gov registry (NCT04417101) registered 30 May 2020.

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Preventive Administration of Juanbi Capsules () for Knee Osteoarthritis: Effects on Serum MMP-2 and MMP-9 levels and Cartilage Repair

Cited by 8 publications

References 7 publications

Insights into the Action Mechanisms of Traditional Chinese Medicine in Osteoarthritis

Insights into the Action Mechanisms of Traditional Chinese Medicine in Osteoarthritis

Yougui Pills Attenuate Cartilage Degeneration via Activation of TGF-β/Smad Signaling in Chondrocyte of Osteoarthritic Mouse Model

Assessing the Efficacy of Chinese Herbal Medicine for Dialysis-related Myofascial Pain in the Fistula Arm: Study Protocol for a Pilot Randomized Trial

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