Preventive Effect and Mechanism of Anthocyanins from Aronia Melanocarpa Elliot on Hepatic Fibrosis Through TGF-β/Smad Signaling Pathway

Hao, Ruobing; Gao, Jun; Liu, Hongwei; Zhang, Chenjuan; Huang, Jinpeng; Fan, Jie; Wei, Jie

doi:10.1007/s12013-022-01079-z

Cited by 5 publications

(2 citation statements)

References 24 publications

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“…1,2 However, when sustained injury and inflammation occur in the liver, the synthesis and degradation of extracellular matrix (ECM) rich in type I and III collagens are unbalanced, resulting in excessive increase and abnormal deposition of ECM. 3 Currently, the activation and proliferation of hepatic stellate cells (HSCs) is considered the central link of liver fibrosis. After activation, HSCs become myofibroblasts (MFBs), which synthesize substantial ECM to cause pathological precipitation of ECM in the liver, thereby leading to abnormal liver structure and function to ultimately develop liver fibrosis.…”

Section: Introductionmentioning

confidence: 99%

“…As an immunoresponse to liver injury and repair, liver fibrosis is a pathophysiological process in which scar tissue replaces damaged or necrotic one 1,2 . However, when sustained injury and inflammation occur in the liver, the synthesis and degradation of extracellular matrix (ECM) rich in type I and III collagens are unbalanced, resulting in excessive increase and abnormal deposition of ECM 3 . Currently, the activation and proliferation of hepatic stellate cells (HSCs) is considered the central link of liver fibrosis.…”

Section: Introductionmentioning

confidence: 99%

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Double‐negative T cells regulate the progression of liver fibrosis through Th9 cells differentiation

Han,

Pei,

Sheng

et al. 2023

Liver International

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Our previous study found that double negative T cells (DNTs) could promote the NLRP3 activation through high expression of TNFα, thereby leading to hepatic fibrosis progression. We focused on investigating the role and mechanism of DNTs in regulating the Th9 cells differentiation in liver fibrosis. In our results, among patients with liver fibrosis, the proportions of peripheral blood DNTs and Th9 cells were upregulated and positively correlated. While promoting the progression of liver fibrosis in mice, DNTs could elevate the proportion of Th9 cells and activate the TNFR2-STAT5-NF-κB pathway. The use of IL-9 and TNFα monoclonal antibodies (mAbs) inhibited the effect of DNTs and lowered the proportion of Th9 cells in tissues. In vitro experiments showed that DNTs could promote the Th9 cells differentiation of Naive T cells, while TNFα mAbs could inhibit such effect of DNTs to lower the proportion of Th9 cells. We found that DNTs can activate TNFR2-STAT5-NF-κB pathway by secreting TNFα, thereby promoting the Th9 Cells differentiation to facilitate the progression of liver fibrosis. There is interaction between DNTs and Th9 cells.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Double‐negative T cells regulate the progression of liver fibrosis through Th9 cells differentiation

Han,

Pei,

Sheng

et al. 2023

Liver International

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Double‐Negative T Cells Promote Liver Fibrosis Progression by Regulating Treg/Th17

Han,

Qian,

Pei

et al. 2024

J Biochem & Molecular Tox

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We investigated the mechanism whereby double‐negative T cells (DNTs) regulate Treg/Th17 balance to promote the progression of liver fibrosis. Liver fibrosis was induced with carbon tetrachloride (CCl4) in mice. Mouse DNTs were isolated, amplified and injected. The proportions of iTreg (CDF4+CD25+Foxp3+) and Th17 (CD4+IL‐17A+) in peripheral mononuclear cells, spleen and liver were analyzed by flow cytometry, and the cytokine levels were determined through enzyme‐linked immunosorbent assay (ELISA). DNTs could promote the Th17 differentiation and inhibit the iTreg differentiation. The role of DNTs in promoting liver fibrosis progression and tissue inflammation was exerted through activation of IκBa. The use of IL‐17A monoclonal antibody enabled suppression of the DNTs effects, reduction of the Th17 proportion and alleviation of liver fibrosis. Hal could suppress the Th17 differentiation and the effect of DNTs. DNTs can promote the Th17 differentiation through IL‐17A and inhibit iTreg differentiation, thereby facilitating the liver fibrosis progression and microenvironmental inflammation. DNTs are a kind of important immunocytes that promote the liver fibrosis progression.

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Aronia Melanocarpa Elliot Anthocyanins Inhibits Alcoholic Liver Disease by Activation of α7nAChR

Wei,

Tang,

et al. 2024

Plant Foods Hum Nutr

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Preventive Effect and Mechanism of Anthocyanins from Aronia Melanocarpa Elliot on Hepatic Fibrosis Through TGF-β/Smad Signaling Pathway

Cited by 5 publications

References 24 publications

Double‐negative T cells regulate the progression of liver fibrosis through Th9 cells differentiation

Double‐negative T cells regulate the progression of liver fibrosis through Th9 cells differentiation

Double‐Negative T Cells Promote Liver Fibrosis Progression by Regulating Treg/Th17

Aronia Melanocarpa Elliot Anthocyanins Inhibits Alcoholic Liver Disease by Activation of α7nAChR

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