Preventive effect of dietary astaxanthin on UVA-induced skin photoaging in hairless mice

Komatsu, Toshiyuki; Sasaki, Suguru; Manabe, Yuki; Hirata, Takashi; Sugawara, Tatsuya

doi:10.1371/journal.pone.0171178

Cited by 90 publications

(95 citation statements)

References 59 publications

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“…12,13 AST also affects ultraviolet A (UVA) radiation as well as desquamation of the epidermis and the extracellular matrix of the dermis. 14 In addition, it improves heart function 15 by increasing the production of antibodies and T-cells, inflammation and age-related macular degeneration.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, stability and bioavailability of astaxanthin succinate diester

et al. 2018

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Section: Introductionmentioning

confidence: 99%

Synthesis, stability and bioavailability of astaxanthin succinate diester

et al. 2018

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“…Dietary AST reduced features of chronic UVA exposure such as TEWL and wrinkle formation in female hairless mice. AST treatment also reduced the mRNA level of epidermal (lympho-epithelial Kazal-type related inhibitor, steroid sulfatase and aquaporin 3) and dermal (MMP-13) markers increased by chronic UVA irradiation 201 .…”

Section: Astaxanthinmentioning

confidence: 92%

Ultraviolet A protective potential of plant extracts and phytochemicals

Škařupová

Vostalová

Svobodová

2020

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Chronic exposure to solar radiation is related to an increased incidence of various skin disorders, including premature skin aging and melanoma and non-melanoma skin cancers. Ultraviolet (UV) photons in particular are responsible for skin damage. Solar UV photons mainly belong to UVA wavebands, however UVA radiation has been mostly ignored for a long time. At the cellular level, UVA photons mainly provoke indirect oxidative damage to biomolecules via the massive generation of unstable and highly reactive compounds. Human skin has several effective mechanisms that forestall, repair and eliminate damage caused by solar radiation. Regardless, some damage persists and can accumulate with chronic exposure. Therefore, conscious protection against solar radiation (UVB+UVA) is necessary. Besides traditional types of photoprotection such as sunscreen use, new strategies are being searched for and developed. One very popular protective strategy is the application of phytochemicals as active ingredients of photoprotection preparations instead of synthetic chemicals. Phytochemicals usually possess additional biological activities besides absorbing the energy of photons, and those properties (e.g. antioxidant, anti-inflammatory) magnify the protective potential of phytochemicals and extracts. Therefore, compounds of natural origin are in the interest of researchers as well as developers. In this review, only studies on UVA protection with well-documented experimental conditions are summarized. This article includes 17 well standardized plant extracts (Camellia sinensis (L.) Kuntze, Silybum marianum L. Gaertn., Punica granatum L., Polypodium aureum L., Vaccinium myrtillus L., Lonicera caerulea L., Thymus vulgaris L., Opuntia ficus-indica (L.) Mill., Morinda citrifolia L., Aloe vera (L.) Burm.f., Oenothera paradoxa Hudziok, Galinsoga parviflora Cav., Galinsoga quadriradiata Ruiz et Pavón, Hippophae rhamnoides L., Cola acuminata Schott & Endl., Theobroma cacao L. and Amaranthus cruentus L.) and 26 phytochemicals.

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“…Although UVC is mostly absorbed by the ozone layer, UVA and UVB penetrate the ozone layer and can cause skin injury. UVA penetrates the dermis, causing wrinkles and loss of elasticity through degradation of the extracellular matrix . Although UVB primarily affects the epidermis and barely reaches the dermis, it is more energetic than UVA and induces DNA damage, oxidative stress, and inflammation of the skin, resulting in various harmful effects, such as dryness, wrinkles, erythema, and pigmentation .…”

Section: Introductionmentioning

confidence: 99%

Effects of hot water extract of Curcuma longa on human epidermal keratinocytes in vitro and skin conditions in healthy participants: A randomized, double‐blind, placebo‐controlled trial

Asada¹,

Ohara²,

Muroyama³

et al. 2019

J of Cosmetic Dermatology

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Summary Background Curcuma longa has been reported to have anti‐inflammatory effects. Skin inflammation impairs skin functions. Objectives Our aim was to investigate the effect of a hot water extract of C longa (WEC) on skin conditions in cell studies using keratinocytes and in clinical trials. Methods We measured proinflammatory cytokine levels in ultraviolet B‐irradiated keratinocytes in the presence or absence of WEC. The effects of WEC on hyaluronan production in keratinocytes were also determined. In a randomized, double‐blind, placebo‐controlled trial, 47 healthy participants were assigned to 8‐week intervention groups with daily intakes of WEC with or without curcumin or a placebo. The water content and transepidermal water loss in the face and minimal erythema dose on the back after ultraviolet B irradiation were evaluated every 4 weeks. Results Hot water extract of C longa significantly inhibited increases in ultraviolet B‐induced tumor necrosis factor α and interleukin 1β at the mRNA and protein levels. WEC also significantly increased hyaluronan production from nonstimulated keratinocytes. In the randomized, double‐blind, placebo‐controlled trial, increases from baseline in the water content of the face were significantly greater at weeks 4 and 8 in the WEC group, but not in the WEC + curcumin group, than in the placebo group. There were no significant differences in transepidermal water loss and minimal erythema dose among the groups. Conclusions The cell studies confirmed that WEC has anti‐inflammatory effects and augments hyaluronan production in the skin. The results of clinical trials suggest that WEC may be useful for moisturizing facial skin. Trial registration UMIN Clinical Trials Registry 000028510. Retrospectively registered.

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Preventive effect of dietary astaxanthin on UVA-induced skin photoaging in hairless mice

Cited by 90 publications

References 59 publications

Synthesis, stability and bioavailability of astaxanthin succinate diester

Synthesis, stability and bioavailability of astaxanthin succinate diester

Ultraviolet A protective potential of plant extracts and phytochemicals

Effects of hot water extract of Curcuma longa on human epidermal keratinocytes in vitro and skin conditions in healthy participants: A randomized, double‐blind, placebo‐controlled trial

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