Preventive effect of doxycycline sponge against bisphosphonate-related osteonecrosis of the jaws: an animal study

Duygu, Gonca; Sapmaz-Metin, Melike; Kütan, Esma; Tomruk, Ceyda Özçakır; Yalçin, Gül Merve; Er, Nilay; Ozfidan, Gulnur Kizilay

doi:10.1080/13102818.2016.1174078

Cited by 4 publications

(7 citation statements)

References 41 publications

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“…Capar et al conducted a study aimed at determining the efficacy of collagen sponges with doxycycline for the purposes of ONJ prevention after extraction. This study proves that the preliminary application of such sponges for extraction, socket, and to cover the wound can be an effective method of preventing osteonecrosis [59].…”

Section: Antibioticsupporting

confidence: 58%

Schemes for Drug-Induced Treatment of Osteonecrosis of Jaws with Particular Emphasis on the Influence of Vitamin D on Therapeutic Effects

et al. 2021

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Drugs that inhibit bone resorption are prescribed most often by orthopedists, hematologists, or oncologists. Dental practice rarely draws attention to their importance and the effects they carry. The problem concerns mainly older people owing to oncological problems or postmenopausal consequences, but everyone can be at risk. Carefully conducted interviews and analysis of history and disease should always be performed before any action is taken by patients taking this type of medicine. Further action should consider possible complications and, above all, the risk of their occurrence. In this article, the most important issues related to the treatment of drug-induced osteonecrosis of the jaws (ONJ) are raised, including medication-related osteonecrosis of the jaw (MRONJ); conservative treatment, including the use of laser; and the impact of vitamin D supplementation on the overall treatment, prognosis, and prevention before complication, which is osteonecrosis of the jaw in the course of treatment with bisphosphonates and other drugs predisposing to MRONJ, such as denosumab and angiogenesis inhibitors. The degree of osteonecrosis is also critical, as it is possible to avoid surgical procedures for only conservative methods that sometimes bring good results. Surgical treatment of advanced stages is complicated and carries a high risk of error and complications. MRONJ is a disease that is easy to avoid, but it is difficult to treat and treatment sometimes leads only to a partial remission of the disease, not a complete cure.

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Section: Antibioticsupporting

confidence: 58%

Schemes for Drug-Induced Treatment of Osteonecrosis of Jaws with Particular Emphasis on the Influence of Vitamin D on Therapeutic Effects

et al. 2021

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“…In Çapar's study, MRONJ developed in rats clinically. Serum CTX, ALP (Alkaline phosphatase), and TRACP-5b biomarker levels were not statistically different between MRONJ and control groups (p>0.05) 24 . In our study, unlike this study, serum TRACP-5b value was found to be lower in the study group developing MRONJ than the control group.…”

Section: Discussionmentioning

confidence: 84%

“…The dose of Z.A. used in our study was determined to be 2.4 mg/ kg for each rat in accordance with similar studies [21][22][23][24] . In our study, zoledronic acid was given 0.2 mg/kg twice a week for 6 weeks to reach a total dose of 2.4 mg/kg.…”

Section: Discussionmentioning

confidence: 99%

“…Another parameter investigated in our study was serum TRACP-5b biomarker levels. Various biochemical markers can contribute to clinicians by carefully examining areas such as monitoring antiresorptive therapy, assessing fracture risk, and assessing the risk of skeletal events in bone metastases 24 . No biomarker has yet been agreed upon and recommended for clinical use.…”

Section: Discussionmentioning

confidence: 99%

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The use of photodynamic therapy on medication-related osteonecrosis of the jaws: Animal study

Karapinar¹,

Zincir²,

Ünür³

et al. 2021

Balkan J Dent Med

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SummaryBackground/Aim: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) was first introduced in 2003 and its scope was expanded by the name medication-related osteonecrosis of the jaw (MRONJ), since 2014. This study aimed to evaluate the effects of photodynamic therapy (FDT) on tissue samples by histopathological and histomorphometric examination and serum TRACP-5b (Tartrateresistant acid phosphatase-5b) measurement in rats.Material and Methods: 24 Sprague-Dawley male rats were divided into 3 groups comprising 8 animals. Zoledronic acid was administered to groups 1 and 2 and 0.9% sodium chloride was administered to group 3 intraperitoneally. After the injections were completed, dental extractions were performed. Photodynamic therapy was applied to group 2, three times a weekfor the two weeks after the extraction. In the 16th week, sacrification was performed. Rats were undergone histopathologic and histomorphometric evaluations.Results: Photodynamic therapy has led to a decrease in epithelial opening and inflammation and an increase in the formation of new bone. Serum TRACP-5b values were shown to decrease significantly in the presence of osteonecrosis.Conclusions: PDT was shown to be useful in reducing MRONJ risk in rats. As a serum biomarker, Serum TRACP-5b could be a valuable marker. Additional studies should confirm the findings.

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“…Lokal doksisiklin uygulaması ise periodontal patojenlere ve aktinomiçes türleri üzerine etkili olup; diş çekimi sonrası enflamasyonun azalmasını da sağlamaktadır. Çalışma sonuçlarına göre bu teknik, önleyici anlamda başarılı bulunmuştur 55 . Karasneh ve ark.…”

Section: Konservatif Tedavilerunclassified

Medication Related Osteonecrosis of Jaws and Current Treatment Modalities

Erdil

Soylu

Altan

et al. 2019

Arşiv Kaynak Tarama Dergisi

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Medication-related osteonecrosis of the jaws (MRONJ), resulting from maxillofacial surgical procedures applied during or after bisphosphonate, antiresorptive and antiangiogenic treatments is a recently defined disease and its etiopathogenesis is still unexplained. There are debates on the treatment approaches of the disease, and the commission established by the American Association for Maxillofacial Surgery publishes guidelines on the definition, staging and treatment procedures of the disease. Nowadays, surgical and conservative treatment methods are used depending on the impact level of bone and soft tissues. It is of utmost importance to prevent the occurence of this disease in patients, who are referred to oral and maxillofacial surgeons, informed about this disease and from the most recent guideline in 2014 motivated about preventive methods. In this review, the articles published in the literature about the applied treatments the guideline in until 2018 were compiled.

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Preventive effect of doxycycline sponge against bisphosphonate-related osteonecrosis of the jaws: an animal study

Cited by 4 publications

References 41 publications

Schemes for Drug-Induced Treatment of Osteonecrosis of Jaws with Particular Emphasis on the Influence of Vitamin D on Therapeutic Effects

Schemes for Drug-Induced Treatment of Osteonecrosis of Jaws with Particular Emphasis on the Influence of Vitamin D on Therapeutic Effects

The use of photodynamic therapy on medication-related osteonecrosis of the jaws: Animal study

Medication Related Osteonecrosis of Jaws and Current Treatment Modalities

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