Preventive effect of Imperatorin on acute lung injury induced by lipopolysaccharide in mice

Sun, Jingjing; Chi, Gefu; Soromou, Lanan Wassy; Chen, Na; Guan, Mingzhi; Wu, Qi; Wang, Dacheng; Li, Hongyu

doi:10.1016/j.intimp.2012.07.019

Cited by 33 publications

(12 citation statements)

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“…Antioxidant properties of imperatorin were postulated by Cao et al ( 2013 ) in the 2-kidney, 1-clip (2 K, 1C) model of hypertension used to investigate the potential antihypertensive effect. Other reports revealed that imperatorin inhibited superoxide dismutase (Raja et al 2011 ), as well as decrease myeloperoxidase activity (Sun et al 2012 ). Moreover, our previous studies also confirmed antioxidative properties of this coumarin.…”

Section: Discussionmentioning

confidence: 94%

Effects of imperatorin on scopolamine-induced cognitive impairment and oxidative stress in mice

et al. 2014

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RationaleImperatorin, a naturally occurring furanocoumarin, inactivates gamma-aminobutyric acid transaminase and inhibits acetylcholinesterase activity.ObjectivesThe purpose of our experiment was to examine the influence of imperatorin on cognitive impairment and oxidative stress in the brain induced by scopolamine in male Swiss mice.MethodsIn the present studies, we used scopolamine-invoke memory deficit measured in passive avoidance (PA) paradigm as an animal model of Alzheimer disease (AD).ResultsOur finding revealed that imperatorin administered acutely at the doses of 5 and 10 mg/kg prior to the injection of scopolamine (1 mg/kg) improved memory acquisition and consolidation impaired by scopolamine. Furthermore, repeatable (7 days, twice daily) administration of the highest dose of imperatorin (10 mg/kg) significantly attenuated the effects of scopolamine on memory acquisition, whereas the doses of 5 and 10 mg/kg of this furanocoumarin were effective when memory consolidation was measured. Imperatorin, administered with scopolamine, increased antioxidant enzymes activity and decreased concentration of malondiamide, an indicator of lipid peroxidation level.ConclusionsThese results demonstrate that imperatorin may offer protection against scopolamine-induced memory impairments and possesses antioxidant properties, thus after further preclinical and clinical studies this compound may provide an interesting approach in pharmacotherapy, as well as prophylactics of AD.

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Section: Discussionmentioning

confidence: 94%

Effects of imperatorin on scopolamine-induced cognitive impairment and oxidative stress in mice

et al. 2014

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“…Examples are columbianadin (17), esculin (23) and imperatorin (29) (Sun et al ., 2012; Lim et al ., 2014; Tianzhu and Shumin, 2015). Esculin inhibited LPS-induced ALI by inhibiting the activation of myeloid differentiation primary response gene 88 (MyD88) (an upstream molecule of NF-κB) and NF-κB p65 activation (Tianzhu and Shumin, 2015).…”

Section: The Inhibition Of Plant Constituents Against In Vivo Animal mentioning

confidence: 99%

Therapeutic Potential of Medicinal Plants and Their Constituents on Lung Inflammatory Disorders

Kim

Lim

Kwon

2016

Biomol Ther (Seoul)

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Acute bronchitis and chronic obstructive pulmonary diseases (COPD) are essentially lung inflammatory disorders. Various plant extracts and their constituents showed therapeutic effects on several animal models of lung inflammation. These include coumarins, flavonoids, phenolics, iridoids, monoterpenes, diterpenes and triterpenoids. Some of them exerted inhibitory action mainly by inhibiting the mitogen-activated protein kinase pathway and nuclear transcription factor-κB activation. Especially, many flavonoid derivatives distinctly showed effectiveness on lung inflammation. In this review, the experimental data for plant extracts and their constituents showing therapeutic effectiveness on animal models of lung inflammation are summarized.

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“…Among them, coumarins were considered as the dominant chemical constituents. It was reported that coumarins possessed various pharmacological effects, such as imperatorin, which had the antihypertensive, antioxidant [5], anti-inflammatory [6], anti-cancer [7], anticonvulsant [8], vasodilatation [9], and anti-HIV-1 [10] activities, and the prevention on lipopolysaccharide (LPS)-induced acute lung injury [11], cerebral ischemia [12], cardiac hypertrophy and heart failure [13]. Isoimperatorin was found to have the anti-Mycobacterium tuberculosis [14] and anti-inflammatory [15] activities, as well as prevention on aflatoxin B 1 -inducible cytotoxicity [16].…”

Section: Var Formosana (Boiss) Shan Et Yuan CV Chuanbaizhi (Radfc)mentioning

confidence: 99%

New coumarins from the roots of Angelica dahurica var. formosana cv. Chuanbaizhi and their inhibition on NO production in LPS-activated RAW264.7 cells

et al. 2015

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Preventive effect of Imperatorin on acute lung injury induced by lipopolysaccharide in mice

Cited by 33 publications

References 34 publications

Effects of imperatorin on scopolamine-induced cognitive impairment and oxidative stress in mice

Effects of imperatorin on scopolamine-induced cognitive impairment and oxidative stress in mice

Therapeutic Potential of Medicinal Plants and Their Constituents on Lung Inflammatory Disorders

New coumarins from the roots of Angelica dahurica var. formosana cv. Chuanbaizhi and their inhibition on NO production in LPS-activated RAW264.7 cells

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