Preventive Effect of Indian Food on Colorectal Cancer

Badsha, Iffath; Kumar, Rajesh; Sunkar, Swetha; Nellore, Jayshree; Muthiah, Bavanilatha; Peela, Sujatha; Nachiyar, C. Valli

doi:10.1007/978-3-030-64668-4_16

Cited by 2 publications

(1 citation statement)

References 129 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Even though they are consumed in small amounts, these herbs and spices contain many bioactive compounds and beneficial health effects. The role of spices and herbs in the inhibition of CRC cells growth has been reported in many recent studies (Zheng et al, 2016;Jaksevicius et al, 2017;Aasim et al, 2018;DeLuca et al, 2018;Khor et al, 2018;Wani and Kumar, 2018;Aiello et al, 2019;Rajasekaran, 2019;Buhrmann et al, 2020;Dandawate et al, 2020;Ganesan et al, 2020;Hallajzadeh et al, 2020;Hu et al, 2020;Malmir et al, 2020;Martínez-Aledo et al, 2020;;Pricci et al, 2020;Badsha et al, 2021;Kammath et al, 2021;Karthika et al, 2021). There is increasing evidence of preventing CRC by consuming fruits and vegetables, while red meat enhances the risk factors (Hallajzadeh et al, 2020).…”

Section: Natural Remedies For Colorectal Cancermentioning

confidence: 97%

Herb and Spices in Colorectal Cancer Prevention and Treatment: A Narrative Review

et al. 2022

View full text Add to dashboard Cite

Colorectal cancer (CRC) is the second most deadly cancer worldwide. CRC management is challenging due to late detection, high recurrence rate, and multi-drug resistance. Herbs and spices used in cooking, practised for generations, have been shown to contain CRC protective effect or even be useful as an anti-CRC adjuvant therapy when used in high doses. Herbs and spices contain many bioactive compounds and possess many beneficial health effects. The chemopreventive properties of these herbs and spices are mainly mediated by the BCL-2, K-ras, and MMP pathways, caspase activation, the extrinsic apoptotic pathway, and the regulation of ER-stress-induced apoptosis. As a safer natural alternative, these herbs and spices could be good candidates for chemopreventive or chemotherapeutic agents for CRC management because of their antiproliferative action on colorectal carcinoma cells and inhibitory activity on angiogenesis. Therefore, in this narrative review, six different spices and herbs: ginger (Zingiber officinale Roscoe), turmeric (Curcuma longa L.), garlic (Allium sativum L.), fenugreek (Trigonella foenum-graecum L.), sesame (Sesamum indicum L.), and flaxseed (Linum usitatissimum L.) used in daily cuisine were selected for this study and analyzed for their chemoprotective or chemotherapeutic roles in CRC management with underlying molecular mechanisms of actions. Initially, this study comprehensively discussed the molecular basis of CRC development, followed by culinary and traditional uses, current scientific research, and publications of selected herbs and spices on cancers. Lead compounds have been discussed comprehensively for each herb and spice, including anti-CRC phytoconstituents, antioxidant activities, anti-inflammatory properties, and finally, anti-CRC effects with treatment mechanisms. Future possible works have been suggested where applicable.

show abstract

Section: Natural Remedies For Colorectal Cancermentioning

confidence: 97%

Herb and Spices in Colorectal Cancer Prevention and Treatment: A Narrative Review

et al. 2022

View full text Add to dashboard Cite

show abstract

Novel VEGFR‐2 Kinase Inhibitors as Anticancer Agents: A Review Focusing on SAR and Molecular Docking Studies (2016–2021)

Vishakha

Kajal

Mondal

et al. 2023

Chemistry & Biodiversity

View full text Add to dashboard Cite

Cancer growth, annexation, and metastatic spread are all aided by the formation of new blood vessels (angiogenesis). The commencement of the VEGF pathway leads to signal transduction that enhances endothelial cell survival, relocation, and divergence from pre-existing vasculature. The ability of solid malignancies to bloom and spread depends critically on their ability to establish their independent blood circulation (tumor angiogenesis). VEGFR is a major receptor tyrosine kinase that regulates angiogenesis, cell growth, and metastasis, diminishing apoptosis, cytoskeletal function, and other biological processes VEGFR has proven to be a remarkable focus for a variety of anticancer medicines in clinical studies. This Review explores the development of anti-VEGF-based antiangiogenic therapies having different scaffolds. This review had focused on SAR and docking studies of previously reported molecules.

show abstract

Preventive Effect of Indian Food on Colorectal Cancer

Cited by 2 publications

References 129 publications

Herb and Spices in Colorectal Cancer Prevention and Treatment: A Narrative Review

Herb and Spices in Colorectal Cancer Prevention and Treatment: A Narrative Review

Novel VEGFR‐2 Kinase Inhibitors as Anticancer Agents: A Review Focusing on SAR and Molecular Docking Studies (2016–2021)

Contact Info

Product

Resources

About