Preventive effect of N-stearoylethanolamine on memory disorders, blood and brain biochemical parameters in rats with experimental scopolamine-induced cognitive impairment

Abstract

The impairment of cognitive functions is the most studied medical and social problem nowadays. The aim of this study was to evaluate the protective effects of n-stearoylethanolamine (nSe) on memory state, blood and brain biochemical parameters in rats under scopolamine-induced cognitive impairment. The results of this study shown that nSe administration to rats per os (5 mg/kg, 5 days, during last 3 days nSe was administrated 20 min prior to scopolamine injection (1 mg/kg, once daily for 3 days, intraperitoneally)) prevented the development of memory impairment. In particular, NSe action was associated with the prevention of increase in acetylcholinesterase activity, changes in phospholipid, free and esterified cholesterol level in hippocampus and frontal cortex, and disruption in pro-/antioxidant balance in blood and studied brain sections. considering the above mentioned biological effects, nSe is a promising drug candidate for integrative therapy of cognitive impairment of different profiles.

Different Effects of Nicotine and N-Stearoyl-ethanolamine on Episodic Memory and Brain Mitochondria of α7 Nicotinic Acetylcholine Receptor Knockout Mice

“…Previous experiments demonstrated neuroprotective effect of NSE in the model of chronic morphine dependence [52,53] and its anti-acetylcholine esterase and pro-cognitive activity in the model of cholinergic deficiency caused by scopolamine [54]. We also showed that NSE restored memory and α7 nAChR content and stabilized mitochondria in the brains of WT mice either injected with LPS or immunized with the α7 extracellular domain (1-208) [22].…”

The state of antioxidant system and emotional status in rats with mild blast-induced traumatic brain injury

“…The main ones are superoxide dismutase, catalase, glutathione peroxidase, and glutathione. Auxiliary enzymes include glutathione reductase, glutathione S-transferase, and glucose-6-phosphate dehydrogenase, as well as metal-binding proteins: transferrin, ceruloplasmin and albumin, vitamins: alpha-tocopherol, ascorbate and beta-carotene, flavonoids and urates [27]. Glutathione reductase is an enzyme that reduces glutathione disulfide to glutathione with the participation of NADPH.…”