Preventive effect of preoperative portal vein ligation on endotoxin-induced hepatic failure in hepatectomized rats is associated with reduced tumour necrosis factor α production

Abstract

Prevention of endotoxin-induced liver failure by preoperative PVL is associated with reduced production of TNF-alpha in the later phase of liver regeneration.

Right Portal Vein Ligation is as Efficient as Portal Vein Embolization to Induce Hypertrophy of the Left Liver Remnant

“…14 However, in an experimental model, Krupski et al 24 showed that the increase of liver volume after PVL was not restrained by the formation of porto-portal collaterals. The fortnight normalization of increased portal blood flow induced by portal vein occlusion in humans 25 and the early peak of hepatocyte proliferation after portal occlusion in rodents 26,27 suggest that liver hypertrophy is early induced after portal occlusion. Then, later formation of porto-portal collaterals would not impact on the induced liver hypertrophy.…”

A systematic review and meta-analysis of portal vein ligation versus portal vein embolization for elective liver resection

“…The increased portal blood flow induced by portal vein occlusion seems to normalize in 2 weeks, with early peak of hepatocyte proliferation after portal occlusion, suggesting that liver hypertrophy is induced early after portal occlusion. [37][38][39] Then, later formation of portoportal collaterals would not impact on the induced liver hypertrophy. This process may explain the comparable increase in FLR with both techniques in the majority studies.…”

Comparative Study of Compensatory Liver Regeneration in a Rat Model: Portal Vein Ligation Only versus Sequential Ligation of the Portal Vein and Hepatic Artery

“…They explained that one of the reasons for the larger liver volumes is the portoportal collateral vessels. However, as in other several studies, fortnight normalization of increased portal blood flow induced by portal vein occlusion in humans and the early peak of hepatocytes proliferation after portal occlusion in rodents suggests that liver hypertrophy after portal occlusion is induced earlier than the formation of portoportal collateral formation (19)(20)(21). Hence, this may have little impact on liver hypertrophy.…”