Preventive effect of Rhododendron arboreum on cardiac markers, lipid peroxides and antioxidants in normal and isoproterenol-induced myocardial necrosis in rats

Mudagal, P.

doi:10.5897/ajpp11.007

Cited by 13 publications

(5 citation statements)

References 24 publications

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“…The intracellular antioxidant system comprises different free radical scavenging antioxidant enzymes along with some non-enzyme antioxidants like GSH and other thiols. CAT, GST, GPx and GR constitute the first line of cellular antioxidant defense enzymes 43 .…”

Section: Discussionmentioning

confidence: 99%

Untitled

2014

IJPSR

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To investigate the cardioprotective effect of methanolic extract of Gardenia gummifera root (MEGG) on Isoproterenol (ISO) induced myocardial infarction (MI) in rats. Methods: LCMS analysis of MEGG was done for the identification of cardioprotective constituents. Myocardial infarction was induced by the subcutaneous injection of ISO (6mg/100g body weight) at an interval of 24 h for 2 days. MEGG (125 and 250 mg/kg, p.o) was given to rats once daily for 45 days before the ISO challenge. The myocardial damage was assessed by quantifying the serum levels of cardiac marker enzymes (LDH, AST, ALT, CK-MB), serum iron and iron binding capacity, uric acid, and ceruloplasmin. Antioxidants such as catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST) and reduced glutathione (GSH) were altered in MI rats. The level of lipid peroxidation was measured as malondialdehyde (MDA), triphenyl tetrazolium chloride (TTC) test, and quantification of histopathological changes also supported the dose-dependent protective effects of MEGG. Results: MEGG significantly (p ≤ 0.05) protected the above-mentioned parameters from falling from normal levels. LCMS analysis of MEGG revealed the presence of cardioprotective constituents such as erythrodiol, lupeol, epicatechin, βsitosterol, asiatic acid, myricetin, oleanolic aldehyde, vernolic acid, chlorogenic acid, and dicaffeoylquinic acid. Conclusion: Our results suggest that MEGG affords a dose dependant cardioprotection against isoproterenol-induced myocardial infarction.

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Section: Discussionmentioning

confidence: 99%

Untitled

2014

IJPSR

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“…Significantly decreased in the concertation of LDH (lactate dehydrogenase), ALT (alanine aminotransferase), and AST (aspartate aminotransferase) was in the rat serum for after pretreatment of these plant extract for 42 days in a dosedependent manner as compared with disease group. Beside with the cardioprotective effect and have antioxidant potential might be due to the presence of flavonoids 25 .…”

Section: Cardioprotective Activitymentioning

confidence: 99%

Traditional uses, Pharmacology and Phytochemistry of National flower of Nepal Rhododendron arboreum: A Review

Ahmad

Ali

Wahab

et al. 2022

J. Drug Delivery Ther.

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Methods: This review provides scientific grounds in the literature for the phytochemical and pharmacological activities of Rhododendron arboreum, from 2010- 2021. Chiefly three bibliographic databases were used as the main sources of information (Google scholar, PubMed, and Science Direct). The keywords used in this research are as follows: “Phytochemical”, “National flower”, “Bioactive compounds”, “Pharmacology” and “Rhododendron arboreum”. Results: Various studies were included in this review according to the required criteria, including phytochemical and traditional uses. Rhododendron arboreum contains flavonoids alkaloids, terpenoids, glycosides, steroids, anthraquinones, saponins and tannins. Pharmacological and traditional uses of this plant on the basis of presence of above active ingredients. Keywords: Bioactive compounds, National flower, Rhododendron arboreum

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“…Myocardial infarction (MI) is one of the main causes of death from cardiovascular disease. MI is defined as an acute condition of necrosis of the myocardium that occurs as a result of imbalance between coronary blood supply and myocardial demand (Mudagal et al, 2011). MI increases the generation of reactive oxygen species in ischemic tissue, bringing about oxidative damage of membrane lipids, proteins, carbohydrates, and DNA and brings changes in the mechanical, electrical, structural and biochemical properties of the heart (Wang et al, 2009) thus a great deal of research is focused on the role of antioxidants in the prevention of many human diseases, particularily atherosclerosis, congestive heart failure and myocardial ischemia reperfusion injury restaraion of the flow of blood to a previously ischemic tissue or organ (Patel et al, 2010 andTinkel et al, 2012).…”

Section: Intruductionmentioning

confidence: 99%

Biochemical Effect of Olive Leaves on Experimentally Induced Cardiac Stress in Rats

El-Maksoud

Mohammed

Hassan

2015

Benha Veterinary Medical Journal

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Preventive effect of Rhododendron arboreum on cardiac markers, lipid peroxides and antioxidants in normal and isoproterenol-induced myocardial necrosis in rats

Abstract: This study was designed to investigate the preventive effect of ethanolic extract of Rhododendron arboretum (ERA) against isoproterenol-induced myocardial ischemia in rat myocardium. Wister rats were pretreated with ERA (100, 250, 500 mg kg

Cited by 13 publications

References 24 publications

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Traditional uses, Pharmacology and Phytochemistry of National flower of Nepal Rhododendron arboreum: A Review

Biochemical Effect of Olive Leaves on Experimentally Induced Cardiac Stress in Rats

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