Preventive effects of a standardized flavonoid extract of safflower in rotenone-induced Parkinson's disease rat model

Ablat, Nuramatjan; Liu, Runzhe; Ablimit, Mihray; Sun, Yi; Xu, Feng; Zhao, Xin; Han, Hongbin; Pu, Xiaoping

doi:10.1016/j.neuropharm.2022.109209

Cited by 7 publications

(6 citation statements)

References 64 publications

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“…70 In PD models, kaempferol inhibit the reducion of dopamine and its metabolites DOPAC, serotonin, and its metabolite 5-HIAA, and reverse the downregulation of tyrosine hydroxylase in dopaminergic neurons. 71 Additionally, kaempferol has a binding effect on dopamine neurotransmitter receptors. 72 A study found that kaempferol also exhibits an antinociceptive effect by inhibiting 5-HT3A (5-hydroxytryptamine) receptors in a concentration-dependent manner.…”

Section: Neurotransmitter Releasingmentioning

confidence: 99%

“…Kaempferol inhibits acetylcholinesterase and acts as a positive allosteric modulator of the α7‐nACh receptor 70 . In PD models, kaempferol inhibit the reducion of dopamine and its metabolites DOPAC, serotonin, and its metabolite 5‐HIAA, and reverse the downregulation of tyrosine hydroxylase in dopaminergic neurons 71 . Additionally, kaempferol has a binding effect on dopamine neurotransmitter receptors 72 .…”

Section: Mechanisms Of Neurological Disease Pathogenesis and The Inhi...mentioning

confidence: 99%

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Exploring the mechanisms of kaempferol in neuroprotection: Implications for neurological disorders

Nezhad Salari,

Rasoulizadeh,

Shabgah

et al. 2024

Cell Biochemistry & Function

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Kaempferol, a flavonoid compound found in various fruits, vegetables, and medicinal plants, has garnered increasing attention due to its potential neuroprotective effects in neurological diseases. This research examines the existing literature concerning the involvement of kaempferol in neurological diseases, including stroke, Parkinson's disease, Alzheimer's disease, neuroblastoma/glioblastoma, spinal cord injury, neuropathic pain, and epilepsy. Numerous in vitro and in vivo investigations have illustrated that kaempferol possesses antioxidant, anti‐inflammatory, and antiapoptotic properties, contributing to its neuroprotective effects. Kaempferol has been shown to modulate key signaling pathways involved in neurodegeneration and neuroinflammation, such as the PI3K/Akt, MAPK/ERK, and NF‐κB pathways. Moreover, kaempferol exhibits potential therapeutic benefits by enhancing neuronal survival, attenuating oxidative stress, enhancing mitochondrial calcium channel activity, reducing neuroinflammation, promoting neurogenesis, and improving cognitive function. The evidence suggests that kaempferol holds promise as a natural compound for the prevention and treatment of neurological diseases. Further research is warranted to elucidate the underlying mechanisms of action, optimize dosage regimens, and evaluate the safety and efficacy of this intervention in human clinical trials, thereby contributing to the advancement of scientific knowledge in this field.

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Section: Neurotransmitter Releasingmentioning

confidence: 99%

Section: Mechanisms Of Neurological Disease Pathogenesis and The Inhi...mentioning

confidence: 99%

Exploring the mechanisms of kaempferol in neuroprotection: Implications for neurological disorders

Nezhad Salari,

Rasoulizadeh,

Shabgah

et al. 2024

Cell Biochemistry & Function

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“…The safflower flavonoid extract (SAFE) showed significant anti-PD effects, which might be due to the anti-inflammatory activity of flavonoids (Lei et al, 2020). Molecular docking analysis revealed that key components of SAFE, such as kaempferol-3-O-rutinoside or AHSYB, can bind to proteins such as TH, JAK2, STAT3, and α7-nAChR (Ablat et al, 2022). Thus, SAFE is a potential drug candidate for PD prevention.…”

Section: Neuroprotective Effectsmentioning

confidence: 99%

Genetic diversity, clinical uses, and phytochemical and pharmacological properties of safflower (Carthamus tinctorius L.): an important medicinal plant

Cheng,

Yang,

et al. 2024

Front. Pharmacol.

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Safflower (Carthamus tinctorius L.), a member of the Asteraceae family, is widely used in traditional herbal medicine. This review summarized agronomic conditions, genetic diversity, clinical application, and phytochemicals and pharmacological properties of safflower. The genetic diversity of the plant is rich. Abundant in secondary metabolites like flavonoids, phenols, alkaloids, polysaccharides, fatty acids, polyacetylene, and other bioactive components, the medicinal plant is effective for treating cardiovascular diseases, neurodegenerative diseases, and respiratory diseases. Especially, Hydroxysafflor yellow A (HYSA) has a variety of pharmacological effects. In terms of treatment and prevention of some space sickness in space travel, safflower could be a potential therapeutic agent. Further studies are still required to support the development of safflower in medicine. Our review indicates that safflower is an important medicinal plant and research prospects regarding safflower are very broad and worthy of further investigation.

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“…In addition, we built a PPI network based on the common targets (Figure S1C Next, we explored whether Alpinetin modulates LPS-induced neuroinflammation through the JAK/STAT pathway. JAK2 and STAT3 are key proteins in this pathway, 40 playing an important role in multiple CNS pathologies, such as Alzheimer's disease, 41 Parkinson's disease, 42 and cerebral ischemic disorders. 43 Additionally, JAK2 was identified as a common core target by topological and MCODE clustering analysis.…”

Section: Alpinetin Reduced the Levels Of Proinflammatory Cytokines In...mentioning

confidence: 99%

“…BBB scores varied from 0 (total paralysis) to 21 (normal exercise). BBB scores were performed at 1,3,7,14,21,28,35,42,49, and 56 days after SCI to assess the extent of recovery of the hind limbs of the rats after injury. Footprint testing was performed 28 and 56 days after surgery for each group of rats.…”

Section: Behavioral Assessmentmentioning

confidence: 99%

Alpinetin inhibits neuroinflammation and neuronal apoptosis via targeting the JAK2/STAT3 signaling pathway in spinal cord injury

et al. 2023

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Background A growing body of research shows that drug monomers from traditional Chinese herbal medicines have antineuroinflammatory and neuroprotective effects that can significantly improve the recovery of motor function after spinal cord injury (SCI). Here, we explore the role and molecular mechanisms of Alpinetin on activating microglia‐mediated neuroinflammation and neuronal apoptosis after SCI. Methods Stimulation of microglia with lipopolysaccharide (LPS) to simulate neuroinflammation models in vitro, the effect of Alpinetin on the release of pro‐inflammatory mediators in LPS‐induced microglia and its mechanism were detected. In addition, a co‐culture system of microglia and neuronal cells was constructed to assess the effect of Alpinetin on activating microglia‐mediated neuronal apoptosis. Finally, rat spinal cord injury models were used to study the effects on inflammation, neuronal apoptosis, axonal regeneration, and motor function recovery in Alpinetin. Results Alpinetin inhibits microglia‐mediated neuroinflammation and activity of the JAK2/STAT3 pathway. Alpinetin can also reverse activated microglia‐mediated reactive oxygen species (ROS) production and decrease of mitochondrial membrane potential (MMP) in PC12 neuronal cells. In addition, in vivo Alpinetin significantly inhibits the inflammatory response and neuronal apoptosis, improves axonal regeneration, and recovery of motor function. Conclusion Alpinetin can be used to treat neurodegenerative diseases and is a novel drug candidate for the treatment of microglia‐mediated neuroinflammation.

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Preventive effects of a standardized flavonoid extract of safflower in rotenone-induced Parkinson's disease rat model

Cited by 7 publications

References 64 publications

Exploring the mechanisms of kaempferol in neuroprotection: Implications for neurological disorders

Exploring the mechanisms of kaempferol in neuroprotection: Implications for neurological disorders

Genetic diversity, clinical uses, and phytochemical and pharmacological properties of safflower (Carthamus tinctorius L.): an important medicinal plant

Alpinetin inhibits neuroinflammation and neuronal apoptosis via targeting the JAK2/STAT3 signaling pathway in spinal cord injury

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