Preventive Effects of Apple Polyphenol Extract on High-Fat-Diet-Induced Hepatic Steatosis Are Related to the Regulation of Hepatic Lipid Metabolism, Autophagy, and Gut Microbiota in Aged Mice

Yin, Yan; Xie, Yisha; Wu, Zhengli; Qian, Qingfan; Yang, Hao; Li, Shilan; Li, Xinli

doi:10.1021/acs.jafc.3c00596

Cited by 7 publications

(1 citation statement)

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“…In our study, the ratio of Bacteroidetes to Firmicutes of the dogs fed the SC diet significantly increased compared with that of the dogs fed the CON diet by days 21 and 42, and the ratio of Bacteroidetes to Firmicutes increased over time in the SC group. Compared with young mice, the ratio of Firmicutes and Bacteroidota in the gut of aged mice over 1 year old was significantly reduced, accompanied by lipid and glucose metabolic disorders and liver damage [ 58 ]. Another study showed that mice receiving microbiota from aged or young mice exhibited significant changes in their gut microbial diversity and composition.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Dietary Saccharomyces cerevisiae Supplementation on Gut Microbiota Composition and Gut Health in Aged Labrador Retrievers

Cui,

Li,

Zhang

et al. 2024

Animals

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The intestinal microbiome changes with age, influencing the host’s health and immune status. Saccharomyces cerevisiae (S. cerevisiae) positively affects intestinal function in humans and animals, but its effects on gut health and the microbiota profile in aged dogs have not been thoroughly investigated. Twenty aged Labrador Retrievers were divided into two groups: a control group (CON) and a S. cerevisiae group (SC). The experiment lasted for 42 days, with assessments of their intestinal barrier function, inflammatory factors, antioxidant markers, and fecal microbiome composition. The results showed that dietary S. cerevisiae reduced the levels of TNF-α, IL-6, and IL-1β in the serum (p < 0.05). In the SC group, plasma superoxide dismutase and glutathione peroxidase activities increased, while the level of malondialdehyde significantly decreased (p < 0.05). Additionally, dietary S. cerevisiae lowered the serum zonulin and lipopolysaccharide (LPS) levels (p < 0.05) and inhibited fecal ammonia production (p < 0.05). Furthermore, the microbiota profile showed that dietary S. cerevisiae decreased the abundance of Firmicutes but increased the Chao index, the abundance of Bacteroidetes, and the proportion of Bacteroidetes to Firmicutes (p < 0.05). To conclude, dietary S. cerevisiae can regulate the gut’s microbial structure and gut health, which may contribute to the overall health of companion animals as they age.

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Section: Discussionmentioning

confidence: 99%