Preventive effects of COX-2 inhibitor, celecoxib on renal tubular injury induced by shock wave lithotriptor

Abstract

Our study was designed to investigate the protective effect of the COX-2 inhibitor, celecoxib, on renal tubules against shock wave lithotripsy (SWL). Sprague-Dawley rats were randomly divided into three groups: sham, control, and COX-2 groups. The control group was administrated normal saline. The COX-2 group was administered celecoxib (10 mg/kg). After administration for 1 week, the control and COX-2 groups received 1,000 shock waves. Before and after SWL, 24-h urine was collected. CCr was measured to assess renal function. To determine the renal tubular injury, N-acetyl glucosaminidase (NAG) and beta-2 microglobulin levels in urine were quantified. The COX-2 gene expression was compared between the three groups. Prior to SWL, all groups had similar levels of NAG and beta-2 microglobulin. After SWL, all groups showed similar CCr. Compared with the sham group, control and COX-2 groups produced increase of NAG and beta-2 microglobulin excretion. However, NAG and beta-2 microglobulin excretions were significantly lower in the COX-2 group than control group. The COX-2 gene expression did not increase in the sham group. However, the COX-2 gene expression was significantly increased in the control group, which was prevented by celecoxib in COX-2 group. Biochemical findings supported a renal protective effect of celecoxib on SWL. This study suggests that celecoxib would be useful prior and after SWL because of renal protective effects.

Effect of theCopaifera langsdorffiiDesf. Leaf Extract on the Ethylene Glycol-Induced Nephrolithiasis in Rats

“…Kaurenoic acid is a diterpene with potent anti-inflammatory activity by the inhibition of the inducible nitric oxide synthase (iNOS) and ciclooxigenase-2 (COX-2) expression [28, 29]. COX-2 inhibitors such celecoxib have protective effects against transient renal dysfunction that occurs due to the shock waves in the shock waves lithotripsy treatment [30]. Additionally, it has been demonstrated that kaurenoic acid produces a vasorelaxation by inhibition of the Ca 2+ influx [31].…”

Celecoxib has Preventive and Therapeutic Benefits against Nephrotoxicity Caused by Gentamicin in Mice

“…Cyclooxygenase-2 (COX-2), the inducible isoform of COX, has only been found in a few organs, including the kidneys [17]. Selective COX-2 inhibitors provide potent anti-inflammatory and analgesic effects without the side effects of gastric and renal toxicity and inhibition of platelet function [18].…”