Preventive effects of drinking green tea on cancer and cardiovascular disease: Epidemiological evidence for multiple targeting prevention

Nakachi, Kei; Matsuyama, Satoru; Miyaké, Satoshi; Suganuma, Masami; Imai, Kazue

doi:10.1002/biof.5520130109

Cited by 368 publications

(256 citation statements)

References 9 publications

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“…Our findings are in general agreement with those of four prospective studies which found no inverse association between green tea consumption and the risk of stomach cancer (Galanis et al, 1998;Nakachi et al, 2000;Nagao et al, 2001;Tsubono et al, 2001). The number of cases of stomach cancer was relatively large in three studies.…”

Section: Discussionsupporting

confidence: 93%

“…Although case -control studies (Kono et al, 1988;Yu and Hsieh, 1991;Yu et al, 1995;Ji et al, 1996;Inoue et al, 1998;Setiawan et al, 2001) have found a reduced risk of stomach cancer in association with green tea consumption, prospective studies (Galanis et al, 1998;Nakachi et al, 2000;Nagao et al, 2001;Tsubono et al, 2001) have not. A recent prospective study found that green tea had a protective effect against stomach cancer.…”

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confidence: 99%

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A nested case–control study of stomach cancer in relation to green tea consumption in Japan

et al. 2004

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To evaluate whether green tea consumption provides protection against stomach cancer, the relative risks (RRs) were calculated in the Japan Collaborative Study for Evaluation of Cancer Risk, sponsored by the Ministry of Health and Welfare (JACC Study). The study was based on 157 incident cases and 285 controls aged 40 -79 years. Cox proportional hazards regression analysis was used to estimate the RRs for stomach cancer. It was found that green tea consumption had no protective effect against stomach cancer. After adjustment for age, smoking status, H. pylori infection, history of peptic ulcer, and family history of stomach cancer along with certain dietary elements, the risks associated with drinking one or two, three or four, five to nine, and 10 or more cups of green tea per day, relative to those of drinking less than one cup per day, were 1.3 (95% confidence interval (CI): 0.6 -2.8), 1.0 (95% CI: 0.5 -1.9), 0.8 (95% CI: 0.4 -1.6), and 1.2 (95% CI: 0.6 -2.5), respectively (P for trend ¼ 0.899). We found no inverse association between green tea consumption and the risk of stomach cancer.

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Section: Discussionsupporting

confidence: 93%

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confidence: 99%

A nested case–control study of stomach cancer in relation to green tea consumption in Japan

et al. 2004

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“…With the exception of one Italian case-control study, 25 studies on tea consumption and HCC risk have been conducted exclusively in Asia (where green tea consumption is more frequent than in Europe); the results are collectively inconclusive. Two studies reported statistically significant inverse associations, 28,29 four inverse but statistically nonsignificant associations, [30][31][32][33] two null associations, 19,34 whereas three reported positive, albeit statistically nonsignificant associations. 17,25,35 A meta-analysis of these studies 9 pointed to a suggestive inverse association of tea with primary liver cancer.…”

Section: Discussionmentioning

confidence: 99%

Coffee, tea and decaffeinated coffee in relation to hepatocellular carcinoma in a European population: Multicentre, prospective cohort study

Bamia

Λάγιου

Jenab

et al. 2014

Intl Journal of Cancer

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Inverse associations of coffee and/or tea in relation to hepatocellular carcinoma (HCC) risk have been consistently identified in studies conducted mostly in Asia where consumption patterns of such beverages differ from Europe. In the European Prospective Investigation into Cancer and nutrition (EPIC), we identified 201 HCC cases among 486,799 men/women, after a median follow‐up of 11 years. We calculated adjusted hazard ratios (HRs) for HCC incidence in relation to quintiles/categories of coffee/tea intakes. We found that increased coffee and tea intakes were consistently associated with lower HCC risk. The inverse associations were substantial, monotonic and statistically significant. Coffee consumers in the highest compared to the lowest quintile had lower HCC risk by 72% [HR: 0.28; 95% confidence intervals (CIs): 0.16–0.50, p‐trend < 0.001]. The corresponding association of tea with HCC risk was 0.41 (95% CI: 0.22–0.78, p‐trend = 0.003). There was no compelling evidence of heterogeneity of these associations across strata of important HCC risk factors, including hepatitis B or hepatitis C status (available in a nested case–control study). The inverse, monotonic associations of coffee intake with HCC were apparent for caffeinated (p‐trend = 0.009), but not decaffeinated (p‐trend = 0.45) coffee for which, however, data were available for a fraction of subjects. Results from this multicentre, European cohort study strengthen the existing evidence regarding the inverse association between coffee/tea and HCC risk. Given the apparent lack of heterogeneity of these associations by HCC risk factors and that coffee/tea are universal exposures, our results could have important implications for high HCC risk subjects.

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“…However, a systematic review of eight studies on green tea reported an OR of 0?82 (95 % CI 0?69, 0?98) (68) and other individual studies on green tea have indicated chemopreventive effects (69)(70)(71)(72)(73) . From nine studies, green tea consumption is possibly related to a decreased risk of colorectal cancer, while black tea consumption possibly has no relationship with colorectal cancer based on twenty-one studies.…”

Section: Cancersmentioning

confidence: 99%

Tea or coffee? A case study on evidence for dietary advice

Binns

Lee

Fraser

2008

Public Health Nutr.

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The present paper explores the level of evidence required to justify giving dietary advice to the public. There are important practical differences between the development of public health nutrition guidelines and guidelines for clinical practice. While the gold standard for evidence for clinical practice guidelines is a meta-analysis of a number of randomised controlled trials, this is often unrealistic and sometimes unethical for the evaluation of public health nutrition interventions. Hence, epidemiological studies make up the bulk of evidence for nutrition guidelines. Tea and coffee are an interesting case study in relation to this issue. They are two of the most commonly consumed beverages worldwide, yet there is little dietary advice on their use. The evidence for a relationship between coffee or tea consumption and several diseases is discussed. The available studies, predominantly epidemiological, together with animal and in vitro studies, indicate that coffee and tea are both safe beverages. However, tea is the healthier option because it has a possible role in the prevention of several cancers and CVD. While the evidence for such relationships is not strong, the public will continue to drink both tea and coffee, and will continue to ask nutritionists to make recommendations. It is therefore argued that advice should be given on the best available data, as waiting for complete data to become available could have severe consequences for public health.

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Preventive effects of drinking green tea on cancer and cardiovascular disease: Epidemiological evidence for multiple targeting prevention

Cited by 368 publications

References 9 publications

A nested case–control study of stomach cancer in relation to green tea consumption in Japan

A nested case–control study of stomach cancer in relation to green tea consumption in Japan

Coffee, tea and decaffeinated coffee in relation to hepatocellular carcinoma in a European population: Multicentre, prospective cohort study

Tea or coffee? A case study on evidence for dietary advice

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