Preventive Effects of Moringa oleifera on Obesity and Hyperlipidaemia: A Systematic Review

Kumar, Sivanesan Raja; Muhammad, Norliza; Fernandez, Mary Nancy; Azlina, Mohd Fahami Nur

doi:10.17576/jsm-2022-5107-18

Cited by 4 publications

(2 citation statements)

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“…Earlier, only its leaf, bark, and pod were reported to be lipid lowering in nature. [28][29][30] Similar type of hypolipidemic effects were also shown by few other flower extracts. [31][32][33] This may be noted that with our results Moringa oleifera plant appears to be helpful in regulating hyperlipidemia with all of its parts.…”

Section: Discussionsupporting

confidence: 64%

Role of flower extract in preventing hyperlipidemia and liver lipid peroxidation in male mice

Kar,

J Jha,

Mahar

2024

IJPP

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: Hyperlipidemia leads to coronary artery disease. Although statins are used conventionally, they are often associated with side effects. It has now been attempted to study the role of flower (MOF) extract in the regulation of tyloxapol-induced hyperlipidemia and tissue lipid peroxidation (LPO) in male mice.Six groups of animals were taken. Group I acted as control and group II, receiving tyloxapol (300 mg/kg, single dose on 14 day) served as hyperlipidemic control. Group III received simvastatin (200 mg/kg), while group IV, V and VI received MOF extract at 400, 200 and 100 mg/kg every day respectively for 15 days. These four groups (III- VI) also received same amount of tyloxapol on 14 day. On day 16 changes in the serum total cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein and very low-density lipoprotein; hepatic LPO, super oxide dismutase, catalase, glutathione peroxidase and histological changes in liver were analyzed. Total phenolic and flavonoid contents were also estimated. The in-vitro antioxidative property was checked through DPPH and HO assays.: Results showed significant reduction in all the serum lipids except HDL, which was increased in MOF treated hyperlipidemic mice, with the parallel decrease in hepatic LPO and increase in antioxidants. Histological studies also showed reduction in hepatic damage with the pre-treatment of MOF. However, the most effective dose was found to be 400 mg/kg of MOF. : We suggest that flower extract may ameliorate hyperlipidemia with antioxidative benefits.

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Section: Discussionsupporting

confidence: 64%

Role of flower extract in preventing hyperlipidemia and liver lipid peroxidation in male mice

Kar,

J Jha,

Mahar

2024

IJPP

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“…Traditionally, porang is used as an antiobesity (16). M. oleifera can be an antiobesity and antihyperlipidaemic agent for losing weight (25). The combination of porang and moringa is best combined agent for weight loss.…”

Section: Body Weight Profilementioning

confidence: 99%

Effect of Combination of Porang and Moringa Flour on Blood Glucose Levels and Body Weight in Rats

Laksmitawati,

Marwati,

Okta

et al. 2024

sciphar

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Porang tuber is rich in fiber and low in calories of carbohydrates. Moringa oleifera leaf has a high protein and a low content of lipids. Obesity and diabetes mellitus are the risk factors of cardiovascular disease, also known as cardiovascular disease risk factors. Combining of porang and moringa as feed can increase nutrition without causing weight gain. This study aims to determine these two materials as antidiabetic and antiobesity agents. The samples are porang tuber, a combination of porang tuber and M. oleifera leaves, a combination of M. oleifera leaves and wheat flour, wheat flour, and standard feed of mice. The parameters tested in this study are analysis of macronutrients of feed, loss of weight of mice, average consuming feed in 28 days, and reduction of blood glucose with a glucometer. The results obtained are a combination of porang tuber and moringa had a low contain carbohydrates and a high contain lipids and protein, can reduction in body weight of 21%, the lowest consumption of feed, and the lowest fasting and postprandial blood glucose levels compared to the other feeds. A combination of porang and moringa can be an antidiabetic and antiobesity agent.

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Antioxidant, anticancer, and anti‐inflammatory potential of Moringa seed and Moringa seed oil: A comprehensive approach

Shahbaz,

Naeem,

Batool

et al. 2024

Food Science & Nutrition

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Moringa oleifera, a widely recognized plant more commonly known as moringa, has obtained significant research interest in recent years due to its prospective physiological advantages, including its claimed ability to counteract carcinogenesis. The moringa plant has been found to possess bioactive components that exhibit promising anticancer activities against different human cancers, such as breast cancer, prostate cancer, pancreatic cancer, etc. The cytotoxic properties of moringa seed extracts on cancerous cells have also been provided in this paper along with other notable health benefits. The extracts derived from moringa seeds inhibit cancer proliferation and promote cancer cell apoptosis through multiple signaling pathways. They also stimulated intracellular reactive oxygen species (ROS) production and subsequently induced caspase‐3 activity. The impact of moringin and avenanthramide 2f on the stimulation of caspases 2, 4, 8, and 9 results in reduction in the proliferation of cancer cells. The results reported by research studies hold significant implications for identifying and targeting specific molecular entities that could serve as potential therapeutic targets in search of effective cancer treatments. Furthermore, the flavonoids in moringa seed can remove mitochondrial reactive oxygen species, protecting beta cells and bringing hyperglycemia under control. M. oleifera seed oil can reduce the risk of cardiovascular diseases via reduced malondialdehyde (MDA) formation and modulation of cardiac superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity. This article provides a comprehensive summary of the noteworthy discoveries derived from a rigorous investigation that explored into the impact of moringa seeds on the prevention/reduction of various cancers and other complex diseases.

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Preventive Effects of Moringa oleifera on Obesity and Hyperlipidaemia: A Systematic Review

Cited by 4 publications

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Role of flower extract in preventing hyperlipidemia and liver lipid peroxidation in male mice

Role of flower extract in preventing hyperlipidemia and liver lipid peroxidation in male mice

Effect of Combination of Porang and Moringa Flour on Blood Glucose Levels and Body Weight in Rats

Antioxidant, anticancer, and anti‐inflammatory potential of Moringa seed and Moringa seed oil: A comprehensive approach

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