Preventive effects of propofol and ketamine on renal injury in unilateral ureteral obstruction

Dikmen, Bayazıt; Yağmurdur, Hatice; Akgül, Turgay; Astarci, Müzeyyen; Üstün, Hüseyin; Germíyanoğlu, Cankon

doi:10.1007/s00540-009-0861-1

Cited by 8 publications

(5 citation statements)

References 40 publications

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“…More importantly, in rats that underwent PHT under propofol anesthesia, there was less iNOS staining than in those that underwent PHT under ketamine anesthesia. Dikmen et al 34 reported that ketamine does not reduce iNOS-mediated NO production upon renal injury in unilateral ureteral obstruction. Those findings suggest that propofol might limit iNOS overexpression and exhibit an anti-apoptotic profile.…”

Section: ■ Discussionmentioning

confidence: 99%

“…The mechanism underlying the hepatoprotective effect of propofol may be explained by the results of studies demonstrating that propofol can produce non-anesthetic organ-protective effects. The latter include: reduction of the generation and scavenging of free radicals; inhibitory effects on calcium channels and reduction of intracellular calcium overload; reduction of the chemotaxis of inflammatory cells; reduction of NO production and apoptosis by downregulation of iNOS expression 34,38 . The antioxidant activity of propofol may mediate its potential role as a modulator of apoptosis 41 .…”

Section: ■ Discussionmentioning

confidence: 99%

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Propofol attenuates cytokine-mediated upregulation of expression of inducible nitric oxide synthase and apoptosis during regeneration post-partial hepatectomy

et al. 2017

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Purpose: To determine the effects of propofol and ketamine anesthesia on liver regeneration in rats after partial hepatectomy (PHT). Methods: Male Wistar albino rats were assigned randomly to four groups of 10. Anesthesia was induced and maintained with propofol in groups 1 and 2, and with ketamine in groups 3 and 4. PHT was undertaken in groups 1 and 3. Rats in groups 2 and 4 (control groups) underwent an identical surgical procedure, but without PHT. At postoperative day-5, rats were killed. Regenerated liver was removed, weighed, and evaluated (by immunohistochemical means) for expression of inducible nitric oxide synthase (iNOS), endothelial NOS (eNOS), apoptosis protease-activating factor (APAF)-1, and proliferating cell nuclear antigen (PCNA). Also, blood samples were collected for measurement of levels of tumor necrosis factor (TNF)-α and interleukin (IL)-6. Results: Between groups 2 and 4, there were no differences in tissue levels of iNOS, eNOS, and APAF-1 or plasma levels of TNF-α and IL-6. eNOS expression was similar in group 1 and group 3. Expression of iNOS and APAF-1 was mild-to-moderate in group 1, but significantly higher in group 3. Groups 1 and 3 showed an increase in PCNA expression, but expression in both groups was comparable. Plasma levels of TNF-α and IL-6 increased to a lesser degree in group 1 than in group 3. Conclusion: Propofol, as an anesthetic agent, may attenuate cytokine-mediated upregulation of iNOS expression and apoptosis in an animal model of liver regeneration after partial hepatectomy.

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Section: ■ Discussionmentioning

confidence: 99%

Section: ■ Discussionmentioning

confidence: 99%

Propofol attenuates cytokine-mediated upregulation of expression of inducible nitric oxide synthase and apoptosis during regeneration post-partial hepatectomy

et al. 2017

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“…31 Based on current evidence, norepinephrine should be used to restore blood pressure within autoregulatory values in hypotensive vasodilated patients with acute kidney injury. 31 According to previous knowledge, propofol is down regulated by nitric oxidase synthase to preserve renal function 32 and protect renal tissue via peroxidation of lipid membrane. 33 Lee et al reported that propofol reduced the new onset of chronic kidney disease after nephrectomy.…”

Section: Original Article Smjmentioning

confidence: 99%

Nomogram as a Predictor for Postoperative Acute Kidney Injury in Super-Elderly Patients Undergoing Noncardiac Surgery

2022

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Objective: There has been increase the incidence of postoperative acute kidney injury (AKI), especially among super-elderly patients. The study aimed to identify risk factors and develop a nomogram among super elderly patients undergoing noncardiac surgery.Material and Methods: A single-center retrospective cohort study of patients aged greater than or equal to 80 years that underwent non-cardiac surgery between January 2018 to December 2020. Acute kidney injury (AKI) was identified by Kidney Disease Improving Global Outcome (KDIGO) during seven days after surgery. Multivariate logistic regression was constructed from preoperative and intraoperative data with variables with P-value<0.2 included in the final model. The performance of model function was conducted by area under the receiver curve (AUC) and calibration curves.Results: Eight hundred and twenty patients were included; 124 (15%) developed postoperative AKI. A multivariate logistic regression model consisting of COPD, ASA classification, part of surgery, propofol and Succinylated gelatin was displayed as the nomogram. The model showed good discrimination with an AUC 0.746. The cutoff point of 63, which had the highest Youden index, was chosen with sensitivity and specificity of 82% and 46%, respectively. The nomogram showed good performance by the Hosmer-Lameshow goodness-of-fit test. (X2= 6.0697 and P value = 0.6394)Conclusion: The nomogram predicted model for predicting postoperative AKI among super-elderly patients showed moderate discrimination ability and was instituted. It can help physicians to detect high-risk patients early and promptly prevent episodes of AKI.

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“…It is a highly lipid-soluble anesthetic that has antioxidant activity against lipid peroxidation under in vitro and in vivo conditions [6]. It inhibits renal renal injury through down-regulating inducible nitric oxide synthase expression [7] and protects HK-2 human kidney proximal tubular epithelial cells against stress induced by H2O2 [8]. Other synthetic opioid analgesic is Fentanyl that is an opioid agonist.…”

Section: Introductionmentioning

confidence: 99%

Comparative effect of propofol versus fentanyl in controlling acute renal colic and its hydronephrosis in patients admitted to the hospital

Hayati

Yazdani

Esmaeili

et al. 2020

Eurasian Chem. Commun.

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Preventive effects of propofol and ketamine on renal injury in unilateral ureteral obstruction

Abstract: Propofol as an anesthetic agent may attenuate NO-induced renal tubular cell apoptosis by downregulating the expression of iNOS in an animal model of unilateral UO.

Cited by 8 publications

References 40 publications

Propofol attenuates cytokine-mediated upregulation of expression of inducible nitric oxide synthase and apoptosis during regeneration post-partial hepatectomy

Propofol attenuates cytokine-mediated upregulation of expression of inducible nitric oxide synthase and apoptosis during regeneration post-partial hepatectomy

Nomogram as a Predictor for Postoperative Acute Kidney Injury in Super-Elderly Patients Undergoing Noncardiac Surgery

Comparative effect of propofol versus fentanyl in controlling acute renal colic and its hydronephrosis in patients admitted to the hospital

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