Preventive effects of resveratrol against early-life impairments in the animal model of autism induced by valproic acid

Schwingel, Gustavo Brum; Fontes-Dutra, Mellanie; Ramos, Bárbara; Riesgo, Rudimar; Bambini-Junior, Victorio; Gottfried, Carmem

doi:10.1016/j.ibneur.2023.09.008

Cited by 2 publications

(1 citation statement)

References 59 publications

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“…An in vivo study evaluating the intrauterine exposure of mice to 0.4% of valproic acid identified alterations in social interaction and cognitive functions, hypersensitivity to heat and pain stimuli in offspring exposed during gestation, behaviors characteristic of ASD [ 77 ]. In this context, several studies have used the animal model of autism induced by valproic acid to study changes related to ASD, with the administration of VPA ranging from 500/600 mg/kg [ 78 , 79 , 80 ].…”

Section: The Influence Of Environmental Hazardsmentioning

confidence: 99%

The Autism Spectrum Disorder and Its Possible Origins in Pregnancy

Botelho,

Silva,

Borbely

2024

IJERPH

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Autism Spectrum Disorder (ASD) belongs to the group of neurodevelopmental disorders, and has a high prevalence, affecting 1 in 100 children according to data from the World Health Organization (WHO). To be diagnosed with ASD, the child must have persistent deficits in communication and social interactions, and restricted and repetitive patterns of behavior, interests, or activities. Despite its prevalence, the etiology of ASD is still uncertain, with multifactorial characteristics, including those associated with the gestational period, where maternal exposure to biological, chemical, or physical hazards occurs, some of which have already been proposed as causes of ASD outcomes. Since pregnancy requires a balance between the maternal–fetal binomial, the breakdown of this balance caused by such environmental hazards can lead to altered fetal neurodevelopment, including ASD. With this firmly in mind, this review aims to compile the most recent data on the gestational causes that may be associated with the development of ASD to help health professionals identify risk factors and act for the prevention and management of ASD.

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Section: The Influence Of Environmental Hazardsmentioning

confidence: 99%

The Autism Spectrum Disorder and Its Possible Origins in Pregnancy

Botelho,

Silva,

Borbely

2024

IJERPH

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Nrf2 and Ferroptosis: Exploring Translational Avenues for Therapeutic Approaches to Neurological Diseases

Mohan,

Mannan,

Kakkar

et al. 2025

CDT

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Nrf2, a crucial protein involved in defense mechanisms, particularly oxidative stress, plays a significant role in neurological diseases (NDs) by reducing oxidative stress and inflammation. NDs, including Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, stroke, epilepsy, schizophrenia, depression, and autism, exhibit ferroptosis, iron-dependent regulated cell death resulting from lipid and iron-dependent reactive oxygen species (ROS) accumulation. Nrf2 has been shown to play a critical role in regulating ferroptosis in NDs. Age-related decline in Nrf2 expression and its target genes (HO-1, Nqo-1, and Trx) coincides with increased iron-mediated cell death, leading to ND onset. The modulation of iron-dependent cell death and ferroptosis by Nrf2 through various cellular and molecular mechanisms offers a potential therapeutic pathway for understanding the pathological processes underlying these NDs. This review emphasizes the mechanistic role of Nrf2 and ferroptosis in multiple NDs, providing valuable insights for future research and therapeutic approaches.

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Preventive effects of resveratrol against early-life impairments in the animal model of autism induced by valproic acid

Cited by 2 publications

References 59 publications

The Autism Spectrum Disorder and Its Possible Origins in Pregnancy

The Autism Spectrum Disorder and Its Possible Origins in Pregnancy

Nrf2 and Ferroptosis: Exploring Translational Avenues for Therapeutic Approaches to Neurological Diseases

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