Preventive Effects of Resveratrol against Azoxymethane Induced Damage in Rat Liver

Gurocak, Simay; Karabulut, Ertuğrul; Karadağ, Neşe; Özgör, Dinçer; Ozkeles, Neslihan; Karabulut, Aysun Bay

doi:10.7314/apjcp.2013.14.4.2367

Cited by 15 publications

(12 citation statements)

References 17 publications

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“…In the present study, AOM induced a significant increase in hepatic lipid peroxidation levels. These findings are in agreement with the studies of Anilakumar et al (2010) andG€ urocak et al (2013) who demonstrated elevated lipid peroxidation in the liver of AOM treated rats. Similarly, AOM-administered mice exhibited significantly elevated hepatic NO levels.…”

Section: Effect Of T Ornata and P Pavonia On Liver Nf-jb And Pparc supporting

confidence: 94%

Brown seaweeds protect against azoxymethane-induced hepatic repercussions through up-regulation of peroxisome proliferator-activated receptor gamma and attenuation of oxidative stress

Abdella

Mahmoud

El-Derby

2016

Pharmaceutical Biology

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Objective: The current study determines the protective efficacy of the brown seaweeds Turbinaria ornata (Turner) J. Agardh (Sargassaceae) and Padina pavonia (Linnaeus) J.V. Lamouroux (Dictyotaceae) against liver injury induced by azoxymethane (AOM). Materials and methods: Male Swiss mice received 10 mg/kg AOM once a week for two consecutive weeks and then 100 mg/kg daily dose of either T. ornata or P. pavonia ethanolic extract. Thirteen weeks after the first AOM administration and 24 h after the last treatment, overnight fasted mice were sacrificed and samples collected. Results: Compared with the AOM group, both T. ornata and P. pavonia significantly decreased the activity of aminotransferases and the concentration of bilirubin while increased albumin levels in the serum. The antioxidative effect of both extracts was observed from the increased activity of superoxide dismutase and glutathione peroxidase activities in the liver, both of which were decreased by AOM. Moreover, the levels of malondialdehyde and nitric oxide were reduced, and histological findings also confirmed the antihepatotoxic activity. In addition, treatment with T. ornata and P. pavonia significantly increased PPARc and decreased NF-jB expression in the liver of AOM-administered mice. Discussion and conclusion: Our findings indicate that the protective function of T. ornata and P. pavonia on AOM-induced liver injury may be possibly exerted by multiple pathways including abolishment of inflammation and oxidative damage, and activation of PPARc. ARTICLE HISTORY

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Section: Effect Of T Ornata and P Pavonia On Liver Nf-jb And Pparc supporting

confidence: 94%

Brown seaweeds protect against azoxymethane-induced hepatic repercussions through up-regulation of peroxisome proliferator-activated receptor gamma and attenuation of oxidative stress

Abdella

Mahmoud

El-Derby

2016

Pharmaceutical Biology

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“…Recently evidence has been accumulated that those side effects like nephrotoxicity and hepatotoxicity are closely related to the activity of reactive oxygen species (ROS) (Gurocak et al, 2013;Rodrigues et al, 2014;Wang et al, 2014). ROS including superoxide anion radical (O 2 ·-), hydroxyl radical (·OH), hydrogen peroxide (H 2 O 2 ), singlet oxygen ( 1 O 2 ) and nitric oxide (NO), which are directly involved in oxidative damage of cellular macromolecules such as lipids, proteins and nucleic acids in tissues.…”

Section: Introductionmentioning

confidence: 99%

Pu-erh Tea Powder Preventive Effects on Cisplatin-Induced Liver Oxidative Damage in Wistar Rats

Zheng¹,

Wang²,

Li³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Asian Pac J Cancer Prev, 15 (17), 7389-7394 IntroductionChemotherapy is one of the major means for malignancy. It seeks to shrink tumors, decrease cancerrelated symptoms, advance quality of life, lengthen life spans of patients, and so on. Many studies have shown the effectiveness and feasibility of chemotherapy for cancers species involving the lung, pancreas, liver, large intestine, and so on. Conversely, treatment with anticancer drugs can also do harm to patients' normal tissues and organs, and those toxicities may lead to a worsened quality of life and shortened survival.Cisplatin (cis-diamminedichloroplatinumⅡ, CDDP) is one of the main chemotherapeutics, which is widely used for the treatment of various malignant solid tumors such as ovarian, lung, testicular and head and neck cancers (Pfister et al., 2010;Dimri et al., 2013; Dua et al., 2013;Besse et al., 2014 AbstractBackground: Chemotherapy is one of the major means for control of malignancies, with cisplatin (CDDP) as one of the main agents, widely used for the treatment of various malignant solid tumors. However, prevention of hepatotoxicity from cisplatin is one of the urgent issues in cancer chemotherapy. In this study, we aimed to investigate the effects of pu-erh tea on hepatotoxicity through body weight and tissue antioxidant parameters like, liver coefficient, serum alanine aminotransferase (ALT), serum aspartate aminotransferase (AST), superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), malondialdehyde(MDA) and glutathione (GSH) levels, and light microscopic evaluation by histological findings. Materials and Methods: The rats were randomly divided into five groups: Control (n=10), cisplatin (3 mg/kg p.i., n=10), cisplatin+pu-erh (0.32 g/kg/day i.g., n=10), cisplatin+pu-erh (0.8 g/kg/day i.g., n=10) and cisplatin+pu-erh (1.6 g/kg/day i.g., n=10). Pu-erh tea powder was administrated for 31 consecutive days. The rats were sacrificed at the end on the second day after a single dose of cisplatin treatment for measuring indices. Results: Pu-erh tea powder exhibited a protective effect by decreasing MDA and GSH and increasing the SOD and GSH-PX levels and GSH-PX/MDA ratio in camparison with the control group. Besides, pu-erh tea was also able to alleviate the pathological damage to some extent. Conclusion: Pu-erh tea powder is protective against cisplatin-induced liver oxidative damages, especially at the medium dosage (0.8 g/kg/d).

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“…Similar clinical, histological and molecular features are identified in human colon cancer (Carter, Lancaster, Hardman, & Cameron, ). AOM has also been used in the investigation of the preventive effects of many vegetables and fruits on colon cancer (Gurocak et al., ).…”

Section: Discussionmentioning

confidence: 99%

Preventive effects of Resveratrol against azoxymethane-induced testis injury in rats

et al. 2016

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To evaluate the protective effects of Resveratrol (RES) on azoxymethane (AOM)-induced testicular damage using histopathology and biochemical analyses, 28 male rats were randomly divided into four groups. Groups were control, RES, AOM and ARES. At the end of the 7 weeks, following routine tissue processing procedure, testis sections were stained with haematoxylin-eosin and Masson's trichrome. The blood samples were taken for biochemical analysis of testosterone, total oxidative stress, total antioxidant status and oxidative stress index. Degenerative changes in the seminiferous tubules such as atrophy, loss in the number of germ cells and arrested spermatogenic cell, and increase in the connective tissue of the tunica albuginea in the groups with AOM treatment were found. RES treatment (ARES) reduced the number of affected seminiferous tubules significantly (p < .05) compared to AOM alone. The testosterone levels in AOM group were significantly lower than in the control group (p < .05). The total oxidative stress levels were significantly higher in AOM group compared to control group (p < .05). The total antioxidant status levels in ARES group were significantly higher than in the AOM group (p < .05). This study results suggest that an antioxidant like Resveratrol may be useful for decreasing the harmful effects of azoxymethane.

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Preventive Effects of Resveratrol against Azoxymethane Induced Damage in Rat Liver

Cited by 15 publications

References 17 publications

Brown seaweeds protect against azoxymethane-induced hepatic repercussions through up-regulation of peroxisome proliferator-activated receptor gamma and attenuation of oxidative stress

Brown seaweeds protect against azoxymethane-induced hepatic repercussions through up-regulation of peroxisome proliferator-activated receptor gamma and attenuation of oxidative stress

Pu-erh Tea Powder Preventive Effects on Cisplatin-Induced Liver Oxidative Damage in Wistar Rats

Preventive effects of Resveratrol against azoxymethane-induced testis injury in rats

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