Preventive effects of thymoquinone in a rat periodontitis model: a morphometric and histopathological study

Özdemir, Hakan; Kara, Mehtap; Ercıyas, Kamile; Özer, Hatice; Ay, Sinan

doi:10.1111/j.1600-0765.2011.01406.x

Cited by 55 publications

(45 citation statements)

References 36 publications

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“…Another study has shown that the alveolar bone loss due to periodontitis was reduced by gastric feeding of TQ to rats. This was accompanied by reduction in osteoclast number and raised osteoblastic activity in TQ-treated rats [29]. In studies using rheumatoid arthritis model, TQ was reported to reduce the serum levels of IL-1 and TNF-α, [30].…”

Section: Discussionmentioning

confidence: 99%

Nigella Sativa reverses osteoporosis in ovariectomized rats

Seif

2014

BMC Complement Altern Med

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BackgroundOsteoporosis poses a significant public health issue. It is a skeletal disorder characterized by compromised bone strength that predisposes to increased risk of fracture. There is a direct relationship between the lack of estrogen after menopause and the development of osteoporosis. About 33% of women over 50 will experience bone fractures as a result of osteoporosis. Nigella Sativa (NS) has been shown to have beneficial effects on bone and joint diseases. The present study was conducted to elucidate the protective effect of Nigella Sativa on osteoporosis produced by ovariectomy in rats.MethodsFemale Wistar rats aged 12–14 months were divided into three groups: sham-operated control (SHAM), ovariectomized (OVX), and ovariectomized supplemented with nigella sativa (OVX-NS) orally for 12 weeks; 4 weeks before ovariectomy and 8 weeks after. After 12 weeks, plasma levels of calcium (Ca+2), phosphorous (Pi), alkaline phosphatase (ALP), amino terminal collagen type 1 telopeptide, malondialdehyde (MDA), nitrates, nitric oxide surrogate, tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) were measured. Histological examination of the liver and the tibia was conducted. Histomorphometric analysis of the tibia was also performed.ResultsOVX rats showed significant decrease in plasma Ca+2, accompanied by a significant increase in plasma ALP, amino terminal collagen type 1 telopeptide, MDA, nitrates, TNF-α and IL-6. These changes were reversed by NS supplementation in OVX-NS group to be near SHAM levels. Histological examination of the tibias revealed discontinuous eroded bone trabeculae with widened bone marrow spaces in OVX rats accompanied by a significant decrease in both cortical and trabecular bone thickness compared to Sham rats. These parameters were markedly reversed in OVX-NS rats. Histological examination of the liver showed mononuclear cellular infiltration and congestion of blood vessels at the portal area in OVX rats which were not found in OVX-NS rats.ConclusionNigella sativa reverses osteoporosis in ovariectomized rats, which could be attributed to its high content of unsaturated fatty acids as well as its antioxidant and anti-inflammatory properties.

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Section: Discussionmentioning

confidence: 99%

Nigella Sativa reverses osteoporosis in ovariectomized rats

Seif

2014

BMC Complement Altern Med

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“…For instance, TQ suppressed the adjuvant induced arthritis and also decreased the periodontitis in rat periodontitis model [10,11]. However the effect of TQ on RANKL induced osteoclastogenesis has not been investigated.…”

Section: Introductionmentioning

confidence: 95%

Thymoquinone prevents RANKL-induced osteoclastogenesis activation and osteolysis in an in vivo model of inflammation by suppressing NF-KB and MAPK Signalling

Thummuri

Jeengar

Shrivastava

et al. 2015

Pharmacological Research

109

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“…10 Recently, antioxidant therapies have been widely researched by investigators 4,8,11 as a result of their effect on bone metabolism via inhibition of osteoclastic activity and promotion of osteoblastic activity. Propolis, a substance made by the honeybee, is an effective antioxidant, antimicrobial, and anti-inflammatory agent.…”

Section: Introductionmentioning

confidence: 99%

Systemic propolis stimulates new bone formation at the expanded suture

Altan

Kara

Nalçacı

et al. 2012

The Angle Orthodontist

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Objective: To investigate the effects of systemically given propolis on the expanded premaxillary suture in a rat study model. Materials and Methods: The 24 rats were randomly divided into three groups-only expansion (OE), expansion plus propolis (PRO), and nonexpansion (control) groups. After the 5-day expansion period was completed, the OE and PRO groups underwent 12 days of mechanical retention. At the end of this period, the animals were euthanatized and their pre-maxillae were dissected and fixed. Histomorphometric examination was performed to determine the number of osteoclasts, osteoblasts, and capillaries as well as the intensity of inflammatory cells and amount of new bone formation. Results: Statistical analysis showed that the intensities of inflammatory cells, number of osteoblasts, and amount of new bone formation were greater in the PRO group than in the other groups. The PRO group also had more osteoclasts and new capillaries. Conclusion: Systemic use of propolis may hasten new bone formation at the expanded suture in rats. (Angle Orthod. 2013;83:286-291.)

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Preventive effects of thymoquinone in a rat periodontitis model: a morphometric and histopathological study

Abstract: The present study showed that the oral administration of thymoquinone diminishes alveolar bone resorption in a rat periodontitis model.

Cited by 55 publications

References 36 publications

Nigella Sativa reverses osteoporosis in ovariectomized rats

Nigella Sativa reverses osteoporosis in ovariectomized rats

Thymoquinone prevents RANKL-induced osteoclastogenesis activation and osteolysis in an in vivo model of inflammation by suppressing NF-KB and MAPK Signalling

Systemic propolis stimulates new bone formation at the expanded suture

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