Preventive Effects of Trimethoprim, Sulphamethoxazole and the Combination Trimethoprim/Sulphamethoxazole on Experimental Staphylococcic Pyelonephritis in Rats

Abstract

108 white rats weighing 170–250 gwere given trimethoprim, sulphamethoxazole and the combination trimethoprim/sulphamethoxazole orally and parenterally in order to test the preventive effect of these substances on experimental hematogenous pyelonephritis due to Staphylococcusaureus. Oral applications of 48 mg/kg/24 h of trimethoprim/sulphamethoxazole prevented abscess formation. Intraperitoneal applications of 48 mg/kg/24 h of the combination did not seem as effective as the oral applications. On the other hand, there was no difference between the effects of oral and parenteral applications when the doses were 96 mg/kg/24 h. The preventive effects of trimethoprim and sulphamethoxazole alone were much less than those observed when the combination trimethoprim/sulphamethoxazole was given. No peritoneal or other tissue damage was observed after intraperitoneal injections of trimethoprim/ sulphamethoxazole in rats.