Preventive efficacy of silver diamine fluoride and MI Varnish on molars affected by molar incisor hypomineralization in children: A randomized controlled trial

Abstract

Background: This randomized controlled trial aimed to compare the efficacy of silver diamine fluoride (SDF) and MI Varnish in preventing caries development, enamel breakdown, and sensitivity on molars affected by molar incisor hypomineralization (MIH) in children. Methods: A total of 100 children aged 6 to 9 years were enrolled in the study with two contralateral permanent molars mildly affected by MIH. Affected molars were randomly and equally assigned to receive either SDF or MI Varnish treatment. The interventions were applied at four different time points (baseline, 3, 6, 9 months), and the incidence of caries, caries progression, enamel breakdown, and sensitivity were assessed. Results: The findings of this study revealed significant differences in the incidence of caries between the groups treated with SDF and MI Varnish (P-value < 0.05). Similarly, there was a significant difference in caries progression between the two groups (P-value < 0.05). However, no significant differences were observed in enamel breakdown scores between the treatment groups, as the majority of teeth in both groups exhibited a score of 0. Furthermore, there were no significant differences in sensitivity between the treatment groups throughout the study period. Conclusions: In conclusion, the results of this study provide evidence that molars treated with SDF demonstrated a lower incidence of caries and a higher rate of caries arrest compared to those treated with MI Varnish. Both interventions showed promise in preventing enamel breakdown and improving sensitivity. These findings highlight the potential of SDF and MI Varnish as effective treatments for caries prevention and management, emphasizing the importance of early intervention and appropriate dental care strategies in maintaining oral health. Trial registration: ISRCTN54243749 (13/01/2022).

Preventive efficacy of 38% silver diamine fluoride and CPP-ACP fluoride varnish on molars affected by molar incisor hypomineralization in children: A randomized controlled trial

“…Each child had two contralateral permanent 1 st molars affected with mild MIH. 24 The distribution of the molars involved in the study is summarized in Table 2 .…”

“…Furthermore, the study was designed and reported according to the Consolidated Standards of Reporting Trials (CONSORT) statement criteria to ensure rigorous and transparent reporting of the study methodology and results. 20…”

Parental satisfaction and acceptance of silver diamine fluoride treatment for molar incisor hypomineralisation in pediatric dentistry: a cross-sectional study

“…It should be noted that the sample population for this study had previously participated in a randomized controlled trial (RCT) comparing the preventive efficacy of SDF and MI Varnish on molars affected by MIH in children 9 . A total of 100 participants met the eligibility criteria and consented to participate in the study.…”

“…One such innovation that has garnered considerable attention in the pediatric dentistry community is the utilization of silver diamine fluoride (SDF) 8 , 9 . This minimally invasive and cost-effective treatment has emerged as a beacon of hope for dental practitioners faced with the task of managing MIH 10 .…”