Preventive role of social interaction for cocaine conditioned place preference: correlation with FosB/DeltaFosB and pCREB expression in rat mesocorticolimbic areas

Rawas, Rana El; Klement, Sabine; Salti, Ahmad; Fritz, Michael E.; Dechant, Georg; Saria, Alois; Zernig, Gerald

doi:10.3389/fnbeh.2012.00008

Cited by 34 publications

(38 citation statements)

References 47 publications

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“…Withdrawal from social contact might derive from a lack of desire to have social contact. As social interactions are able to induce conditioned place preference (El Rawas et al, 2012), the social withdrawal might be explained by anhedonia, the inability to experience pleasure or reward. This explanation is supported by the scent marking test, in which male rats are allowed to approach and scent female urine, and mark the scents by urination.…”

Section: Discussionmentioning

confidence: 99%

The role of the dopamine D1 receptor in social cognition: studies using a novel genetic rat model

Homberg

Olivier

VandenBroeke

et al. 2016

Disease Models &Amp; Mechanisms

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Social cognition is an endophenotype that is impaired in schizophrenia and several other (comorbid) psychiatric disorders. One of the modulators of social cognition is dopamine, but its role is not clear. The effects of dopamine are mediated through dopamine receptors, including the dopamine D1 receptor (Drd1). Because current Drd1 receptor agonists are not Drd1 selective, pharmacological tools are not sufficient to delineate the role of the Drd1. Here, we describe a novel rat model with a genetic mutation in Drd1 in which we measured basic behavioural phenotypes and social cognition. The I116S mutation was predicted to render the receptor less stable. In line with this computational prediction, this Drd1 mutation led to a decreased transmembrane insertion of Drd1, whereas Drd1 expression, as measured by Drd1 mRNA levels, remained unaffected. Owing to decreased transmembrane Drd1 insertion, the mutant rats displayed normal basic motoric and neurological parameters, as well as locomotor activity and anxiety-like behaviour. However, measures of social cognition like social interaction, scent marking, pup ultrasonic vocalizations and sociability, were strongly reduced in the mutant rats. This profile of the Drd1 mutant rat offers the field of neuroscience a novel genetic rat model to study a series of psychiatric disorders including schizophrenia, autism, depression, bipolar disorder and drug addiction.

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Section: Discussionmentioning

confidence: 99%

The role of the dopamine D1 receptor in social cognition: studies using a novel genetic rat model

Homberg

Olivier

VandenBroeke

et al. 2016

Disease Models &Amp; Mechanisms

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“…cocaine self-administration remains to be determined. We tested our hypothesis, i.e., that different small neuron ensembles in the Acb mediate drug versus 'natural' reward, in our paradigm of CPP reversal by dyadic social interaction between gender (i.e., male)-and weightmatched Sprague-Dawley rats [38][39][40][41][42]. Briefly, in this paradigm rats are first trained to acquire CPP for cocaine.…”

mentioning

confidence: 99%

Acetylcholine, Drug Reward and Substance Use Disorder Treatment: Intra- and Interindividual Striatal and Accumbal Neuron Ensemble Heterogeneity May Explain Apparent Discrepant Findings

Prast¹,

Kummer²,

Barwitz³

et al. 2012

Pharmacology

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Converging evidence from different independent laboratories suggests that acetylcholine may play an important role in drug reward and that modulation of the cholinergic system may be useful for the treatment of substance use disorders. In this commentary, we try to reconcile apparently discrepant animal behavioral, human behavioral and clinical data with a unifying hypothesis positing that the modulation of drug-versus natural stimuli-mediated reward by cholinergic interneurons in the nucleus accumbens (and the dorsal striatum) is restricted to distinct neuron ensembles that show considerable intra- and interindividual variation with respect to their spatial distribution. The precise targeting of these interindividually variable neuron ensembles would be a prerequisite for a successful pharmacotherapy based on the modulation of the cholinergic system. We also provide experimental data to support our unifying hypothesis.

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“…Since initiation of nicotine use in humans typically occurs in a social setting (West et al, 1999, Baker et al, 2004, Geckova et al, 2005, Sussman, 2005), the use of social context during acquisition of nicotine self-administration is important and under-utilized in preclinical animal studies. Given that different neural circuits are activated in social versus isolated rodents (Insel, 1992, Young et al, 2001, Fritz et al, 2011a, El Rawas et al, 2012, Bastle et al, 2016), which may influence neural activity when exposed to drugs of abuse (Pentkowski et al, 2011, Bastle et al, 2016), future research aimed at understanding the neural mechanisms that underlie social influences on nicotine self-administration may have important implications for developing treatments for nicotine dependence.…”

Section: Discussionmentioning

confidence: 99%

Social context has differential effects on acquisition of nicotine self-administration in male and female rats

et al. 2017

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Rational Smoking typically begins during adolescence or early adulthood in a social context, yet the role of social context in animal models is poorly understood. Objectives The present study examined the effect of social context on acquisition of nicotine self-administration. Methods Sixty day-old male and female Sprague-Dawley rats were trained to press a lever for nicotine (0.015 mg/kg, IV) or saline infusions (males only) on a fixed-ratio (FR1) schedule of reinforcement across 9 sessions in duplex chambers that were conjoined with either a solid wall or a wall containing wire mesh creating a social context between rat dyads (social visual, auditory, and olfactory cues). In a subsequent experiment, sex differences and dose-dependent effects of nicotine [0 (saline), 0.015 or 0.03 mg/kg, IV] were directly compared in rats trained in the isolated or social context on a schedule progressing from FR1 to FR3. These rats were given 20 sessions followed by 3 extinction sessions. Results We consistently found transient social facilitation of low dose nicotine self-administration in males during the first session. However, across training overall we found social suppression of nicotine intake that was most prominent in females during later sessions. Conclusions Collectively, these findings suggest that at the age of transition from adolescence to adulthood, a social context enhances the initial reinforcing effects of nicotine in males, but protects against nicotine intake during later sessions especially in females. These findings highlight the importance of sex and social context in studying neural mechanisms involved in initiation of nicotine use.

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Preventive role of social interaction for cocaine conditioned place preference: correlation with FosB/DeltaFosB and pCREB expression in rat mesocorticolimbic areas

Cited by 34 publications

References 47 publications

The role of the dopamine D1 receptor in social cognition: studies using a novel genetic rat model

The role of the dopamine D1 receptor in social cognition: studies using a novel genetic rat model

Acetylcholine, Drug Reward and Substance Use Disorder Treatment: Intra- and Interindividual Striatal and Accumbal Neuron Ensemble Heterogeneity May Explain Apparent Discrepant Findings

Social context has differential effects on acquisition of nicotine self-administration in male and female rats

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