Preventive therapy for asthma in children; a 9-year experience in eastern Finland

Korppi, M; Kuikka, Liisa; Remes, Kyllikki

doi:10.1183/09031936.95.08081318

Cited by 12 publications

(11 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our area, all children with chronic or moderate-to-severe asthma are on continuous anti-inflammatory therapy. 30 Serum ECP and EPX concentrations are known to decrease during such therapy, 5,20,31 even if some symptoms persist. 23 Therefore, ECP and EPX values in asthmatic children who were on maintenance medication were as low as in the healthy controls.…”

Section: Discussionmentioning

confidence: 99%

Serum eosinophil cationic protein (ECP) and eosinophil protein X (EPX) in childhood asthma: The influence of atopy

et al. 1998

View full text Add to dashboard Cite

The purpose of this study was to determine the value of serum measurements of eosinophil cationic protein (ECP) and eosinophil protein X (EPX) in diagnosing asthma in children, and to investigate the influence of concomitant allergic diseases and atopic sensitization, assessed by skin prick tests (SPT), on these markers. ECP and EPX were determined in 36 children with asthma, in 33 children with other symptoms from lower airways disease (OSLA), and in 166 control children. Sixteen children with asthma but no anti‐inflammatory therapy had significantly higher concentrations of ECP and EPX (ECP: 27.5 μg/L, P < 0.001; EPX: 59.9 μg/L, P < 0.001) than the control children (ECP: 11.2 μg/L; EPX: 26.2 μg/L). In the 20 children on anti‐inflammatory therapy, ECP values were similar to those of controls. The children with OSLA (ECP: 13.6 μg/L, P < 0.01; EPX: 47.2 μg/L, P < 0.001) differed significantly from controls. When using the value of 24.7 μg/L (97.5 percentile in the 68 non‐atopic controls) as a pathologic upper limit for ECP, 10 (63%) of the 16 asthmatic children on no maintenance medication, two (10%) of the 20 asthmatics on maintenance therapy, and 11 (33%) of the 33 children with OSLA had high ECP; the same figure was only 18 (11%) in the 166 control children. Both ECP and EPX had a significant association with allergic disorders and with SPT reactivity. In multivariate logistic regression analysis, an elevated ECP was significantly associated with asthma (OR 2.3, 95%Cl 1.1–4.9) and atopic dermatitis (2.9, 1.2–6.9), and an elevated EPX was significantly associated with asthma (2.61, 1.19–5.74) and allergic rhinoconjunctivitis (5.23, 1.46–18.73). We conclude that serum concentrations of both ECP and EPX are higher in asthmatic than in healthy children. However, other allergic diseases, such as allergic rhinoconjunctivitis, atopic dermatitis, and allergic skin sensitization also raise the concentrations of these markers. This limits their usefulness in the diagnosis of childhood asthma. Pediatr. Pulmonol. 1998; 25:167–174. © 1998 Wiley‐Liss, Inc.

show abstract

Section: Discussionmentioning

confidence: 99%

Serum eosinophil cationic protein (ECP) and eosinophil protein X (EPX) in childhood asthma: The influence of atopy

et al. 1998

View full text Add to dashboard Cite

show abstract

“…The highest rates of prophylactic pharmacological treatment have been observed in Finland (80%), in the United Kingdom (52.5%), and in the United States (47.5%). (23)(24)(25) In 1988, one group of authors studied 266 children with asthma hospitalized in Australia and found a much higher percentage of individuals Therefore, we conclude that the rate at which such patients seek outpatient follow-up treatment for asthma is far from acceptable, which may be a reflection of the situation in which we find the Brazilian Unified Health Care System. The present study reveals that, among patients hospitalized for acute asthma, full access to treatment and to preventive medication is the exception.…”

Section: Discussionmentioning

confidence: 61%

A hospitalização por asma e a carência de acompanhamento ambulatorial

et al. 2007

View full text Add to dashboard Cite

Objective: To determine whether the children and adolescents with acute asthma attacks admitted to two public hospitals in the city of Recife, Brazil underwent outpatient follow-up treatment for the prevention and control of asthma. Methods: A prospective case series study of hospitalized patients with asthma. The patients were asked to complete a questionnaire at admission in order to determine the frequency of prophylactic outpatient follow-up treatment. Patients presenting two or more attacks of asthma that were responsive to bronchodilators were classified as having asthma. Results: In the intervals between asthma attacks, 67% (112/167 -data regarding 2 patients were not available) of the patients had been treated only in the emergency room. Although 53.3% (89/167 -data regarding 2 patients were not provided) of the patients had been referred to outpatient treatment, only 16% (27/169) had visited an outpatient asthma clinic regularly for preventive treatment, and only 13% (22/169) had used prophylactic medication. Conclusion: Most of the children and adolescents hospitalized with asthma had not undergone preventive outpatient follow-up treatment. Various problems related to the health care system, such as non-referral for outpatient follow-up treatment at hospital discharge, limited access to outpatient clinics, and the cost of prophylactic medication, might have contributed to the low rate of outpatient follow-up treatment in the population studied. Public health care policies that allow asthma control programs to work effectively should be implemented.

show abstract

“…Unfortunately, reliable information for comparison of SII data was not available on the consumption of antiinflammatory drugs in the area until 1995. However, the hospital-based data, gathered mainly from outpatients, suggested that steroids were clearly used less before the year 1995 [20,27].…”

Section: Discussionmentioning

confidence: 99%

Hospitalization trends for paediatric asthma in eastern Finland: a 10-yr survey

Korhonen

Reijonen²,

Malmström³

et al. 2002

Eur Respir J

View full text Add to dashboard Cite

The prevalence of childhood asthma has increased during the past 20 yrs in eastern Finland. The use of regular medication for asthma has, consequently, also risen at the same time. The aim of the present study was to assess how these factors have influenced hospitalization for asthma in children.Data concerning the annual number of children aged v16 yrs treated for asthma, their number of hospital periods, and length of hospitalization were collected using patient-specific medical records for the years 1988-1997.Admissions for asthma more than doubled (from 1.2 in 1,000 to 2.7 in 1,000) (pv0.001), whereas re-admissions decreased from 28.1% to 8.7% (pv0.001) during the study period. The greatest increase was seen among children aged v2 yrs, whereas during recent years the admission rate among children aged w2 yrs has declined by one-third.Despite the increased prevalence of asthma, the decline in admissions seen in all but the youngest children may, at least partly, be attributed to the decrease in re-admissions, resulting from the early onset and increased use of inhaled steroids.

show abstract

Preventive therapy for asthma in children; a 9-year experience in eastern Finland

Cited by 12 publications

References 10 publications

Serum eosinophil cationic protein (ECP) and eosinophil protein X (EPX) in childhood asthma: The influence of atopy

Serum eosinophil cationic protein (ECP) and eosinophil protein X (EPX) in childhood asthma: The influence of atopy

A hospitalização por asma e a carência de acompanhamento ambulatorial

Hospitalization trends for paediatric asthma in eastern Finland: a 10-yr survey

Contact Info

Product

Resources

About