Previous chemotherapy as a predictor of wound infections in nonmajor head and neck surgery: Results of a prospective study

Penel, Nicolas; Fournier, Charles; Lilleri, Daniele; Roussel-Delvallez, M.; Sarini, J.; Kara, A.; Mallet, Y.; Lefebvre, Jean‐Louis

doi:10.1002/hed.20002

Cited by 19 publications

(8 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In NAC-treated early stage tongue cancer cases, the immune response may be debilitated during the postoperative wound healing period. Some authors reported that NAC significantly increased postoperative wound infection in HNSCC patients [45,46]. Although, NAC may kill some residual tumor cells, but disadvantageously blocks the local defense of immune competent cells.…”

Section: Discussionmentioning

confidence: 99%

Predictors of Locoregional Recurrence in T1-2N0 Tongue Cancer Patients

Yanamoto

Yamada

Takahashi

et al. 2013

Pathol. Oncol. Res.

View full text Add to dashboard Cite

Locoregional recurrence of oral tongue squamous cell carcinoma (OTSCC) has been considered a poor prognostic entity in terms of survival rate.The purpose of this study was to evaluate the incidence of locoregional recurrence and to identify significant risk factors for locoregional recurrence in early-stage OTSCC. We retrospectively reviewed the records of 58 patients who underwent radical surgery for T1-2N0 OTSCC. The local recurrence and regional recurrence rates were 10.3% (6/58 patients) and 15.5% (9/58 patients) in this study, respectively. The survival rate of patients with local recurrence was 66.7%, which was significantly lower than that (96.2%) of patients without local recurrence, whereas the survival rates of patients with or without regional recurrence were not significantly difference. Pattern of invasion (POI), neoadjuvant chemotherapy (NAC) and the status of the surgical margin were identified as factors influencing local recurrence. In particular, the status of the deep surgical margin was a high potential independent risk factor. The deep surgical margin was resected closely in many NAC-treated cases, suggesting that NAC may lead to local recurrence and a poor outcome. No efficacy of NAC was observed, suggesting that the standard treatment for early OTSCC is surgery alone.

show abstract

Section: Discussionmentioning

confidence: 99%

Predictors of Locoregional Recurrence in T1-2N0 Tongue Cancer Patients

Yanamoto

Yamada

Takahashi

et al. 2013

Pathol. Oncol. Res.

View full text Add to dashboard Cite

show abstract

“…The advantage of the gastro‐omental flap is the unique ability of the greater omentum to provide a vascularized apron over the pharyngeal anastomosis and great vessels in the neck, and its abundant source of fibroblasts and other progenitor cells, which initiate development of fibrous adhesions and capillary in‐growth within hours of its transfer into a wound bed (Figure 9). 54, 55 This is particularly advantageous when reconstructing a circumferential pharyngeal defect in the current era of salvage surgery following intensive organ preservation protocols, which are associated with a high risk of morbidity because of the well‐documented adverse effect these therapies have on tissue vascularization and wound healing 56–59…”

Section: Gastro‐omental Free Flapmentioning

confidence: 99%

Circumferential pharyngeal reconstruction: History, critical analysis of techniques, and current therapeutic recommendations

et al. 2009

View full text Add to dashboard Cite

Reconstruction of circumferential pharyngeal defects following total pharyngolaryngectomy presents major challenges with respect to surgical morbidity and restoration of functional deficits, which are often made more demanding by the increasing trend to utilize primary chemoradiation protocols with surgery reserved for salvage cases. The present review evaluates the reconstructive techniques described in the literature, including historical techniques as well as more recent innovative methods. Each technique is critically appraised with particular reference to postoperative morbidity and functional rehabilitation. Treatment recommendations are made based on the available evidence.

show abstract

“…Based on this evidence, some have advocated the routine use of perioperative prophylactic antibiotics for more extensive clean, uncontaminated head and neck procedures 9. Factors associated with higher postoperative wound infection rates include poor nutritional status, tobacco and alcohol consumption, prior radiotherapy, prior chemotherapy, prior tracheotomy, major resections with flap reconstruction, duration of surgery, and tumor stage 9–11. We performed a retrospective chart review of patients undergoing neck dissections in which the aerodigestive tract was not violated.…”

Section: Introductionmentioning

confidence: 99%