Previous extensive sun exposure and subsequent vitamin D production in patients with basal cell carcinoma of the skin, has no protective effect on internal cancers

Lindelöf, Bernt; Krynitz, Britta; Ayoubi, Shiva; Martschin, Christoph; Wiegleb-Edström, Desiree; Wiklund, Kerstin

doi:10.1016/j.ejca.2011.06.049

Cited by 17 publications

(18 citation statements)

References 17 publications

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“…This result was also reported in an ecologic study of cancer mortality rates in Spain [48]. However, another case control study from Sweden [49] showed divergent result, the cases with the diagnosis of basal cell carcinoma in skin had an increased risk of getting another form of cancer, and had no correlation with gastric cancer (OR 1.00, 95%CI 0.85-1.17). One limitation of this study is the exposure factor bias, whereby the study completely neglects the factor of sun exposure to patients, which may lead to this contradiction.…”

Section: Vitamin D/vdr and Gastric Cancer: Epidemiological Datasupporting

confidence: 65%

Pathogenic roles of alterations in vitamin D and vitamin D receptor in gastric tumorigenesis

Yang

Zhao

et al. 2017

Oncotarget

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Gastric cancer is currently the second leading cause of cancer-related death worldwide, especially in Japan, Korea and China, and the 5-year survival rate of gastric cancer is less than 30%. Thus, it is important to shed more lights on novel agents to prevent gastric cancer or to improve survival rate of the patients. Vitamin D not only maintains calcium and bone homeostasis, but also mostly inhibits tumor genesis, invasion, and metastasis through activation of vitamin D receptor. Although epidemiological results are not consistent, accumulating evidence from gastric cancer cells, animal models, and clinical trials suggest that vitamin D deficiency may increase the risk and mortality of gastric cancer, but vitamin D supplement might be a safe and economical way to prevent or treat gastric cancer. Here, we reviewed the current studies on vitamin D and its receptor and focused on the pathogenic roles of their alterations in gastric tumorigenesis.

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Section: Vitamin D/vdr and Gastric Cancer: Epidemiological Datasupporting

confidence: 65%

Pathogenic roles of alterations in vitamin D and vitamin D receptor in gastric tumorigenesis

Yang

Zhao

et al. 2017

Oncotarget

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“…This study offers further evidence that diagnosis of NMSC in Nordic countries is associated with increased risk of internal cancers 14 , 15 . In this study, both melanoma and NMSC are inversely correlated with the UVB index, although the link is not statistically significant for NMSC for females.…”

Section: Discussionmentioning

confidence: 45%

“…However, in less sunny countries (Canada and seven northern European countries), all solid tumors except those of the lip and skin were significantly directly correlated with NMSC diagnosis 14 . A recent paper from Sweden found an increased risk of internal cancers for those diagnosed with basal cell carcinoma (BCC) 15 . However, studies in The Netherlands found inverse correlations between NMSC and prostate 16 and colorectal 17 cancer.…”

mentioning

confidence: 99%

Role of solar UVB irradiance and smoking in cancer as inferred from cancer incidence rates by occupation in Nordic countries

Grant

2012

Dermato-Endocrinology

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A large body of evidence indicates that solar ultraviolet-B (UVB) irradiance and vitamin D reduce the risk of incidence and death for many types of cancer. However, most of that evidence comes from midlatitude regions, where solar UVB doses are generally high in summer. Data on cancer standardized incidence ratios (SIRs) by sex and 54 occupation categories based on 1.4 million male and 1.36 million female cancer cases for 1961–2005 in the five Nordic countries provide the basis for an ecological study of the role of solar UVB in the risk of many types of cancer at high latitudes. Lip cancer SIRs less lung cancer SIRs for men was the best index of solar UVB dose, which was weakly inversely correlated with both melanoma and nonmelanoma skin cancer (NMSC) SIRs. Lung cancer SIRs were used as the index of the effects of smoking. For men, the UVB index was significantly inversely correlated with 14 types of internal cancer—bladder, breast, colon, gallbladder, kidney, laryngeal, liver, lung, oral, pancreatic, pharyngeal, prostate, rectal and small intestine cancer. For women, the same UVB index was inversely correlated with bladder, breast and colon cancer. These results generally agree with findings from other studies. These results provide more support for the UVB-vitamin D-cancer hypothesis and suggest that widespread fear of chronic solar ultraviolet (UV) irradiance may be misplaced.

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“…This provided a direct test of the vitamin D hypothesis. The results showed that the risk of internal malignancies was elevated in the interval prior to a BCC diagnosis in patients who eventually were diagnosed with a BCC, providing further evidence that NMSC is a marker of a cancer-prone phenotype (44). …”

Section: Introductionmentioning

confidence: 73%

“…Lindelof and colleagues (44) directly addressed the two competing hypotheses. Patients with a diagnosed BCC may be more likely to engage in sun-protection behaviors, so this study examined the risk of other cancers in the time window before the BCC diagnosis when sun exposure, and thus cutaneous vitamin D synthesis, was likely to be highest.…”

Section: Introductionmentioning

confidence: 99%

Is a Personal History of Nonmelanoma Skin Cancer Associated with Increased or Decreased Risk of Other Cancers?

Alberg

Fischer

2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Two conflicting hypotheses have been tested concerning the association between a personal history of non-melanoma skin cancer (NMSC) and risk of other malignancies. One hypothesis is that as a marker of extensive sunlight exposure and hence vitamin D status, NMSC should be inversely associated with risk of other cancers. Alternatively, under the multiple primary cancer model, NMSC is postulated to be an informative first cancer to study as marker of increased risk of subsequent primary cancer diagnoses. In this journal issue, Ong and colleagues report the results of a large-scale study in the U.K. with findings that NMSC was significantly associated with increased risk of a broad spectrum of other malignancies, with the associations stronger the younger the age of onset of NMSC. These results are consistent with the larger body of evidence on this topic, which is highly asymmetrical in favor of the multiple primary cancer hypothesis. Two divergent hypotheses have been tested, with the empirical evidence unequivocally indicating NMSC is a marker of a high cancer-risk phenotype. Future research is warranted to better characterize this association, to understand why NMSC is a marker of excess risk of other cancers, and to determine if this association is clinically relevant.

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Previous extensive sun exposure and subsequent vitamin D production in patients with basal cell carcinoma of the skin, has no protective effect on internal cancers

Cited by 17 publications

References 17 publications

Pathogenic roles of alterations in vitamin D and vitamin D receptor in gastric tumorigenesis

Pathogenic roles of alterations in vitamin D and vitamin D receptor in gastric tumorigenesis

Role of solar UVB irradiance and smoking in cancer as inferred from cancer incidence rates by occupation in Nordic countries

Is a Personal History of Nonmelanoma Skin Cancer Associated with Increased or Decreased Risk of Other Cancers?

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