Previous Gestational Diabetes Increases Atherogenic Dyslipidemia in Subsequent Pregnancy and Postpartum

Prados, Montserrat; Roux, Juana A. Flores‐Le; Benaiges, David; Llauradó, Gemma; Chillarón, Josep; Payà, Antoni; Pedro‐Botet, Juan

doi:10.1002/lipd.12040

Cited by 12 publications

(9 citation statements)

References 23 publications

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“…The present findings indicated that lipid levels during pregnancy were associated with an increased risk of dyslipidemia after delivery. This finding is consistent with two other studies that also showed a relationship between hypertriglyceridemia in pregnancy and at 6-12 months postpartum [25,26].…”

Section: Discussionsupporting

confidence: 93%

Early postpartum dyslipidemia and its potential predictors during pregnancy in women with a history of gestational diabetes mellitus

et al. 2020

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Background This study aimed to analyze the incidence of early postpartum dyslipidemia and its potential predictors in women with a history of gestational diabetes mellitus (GDM). Methods This was a retrospective study. Five hundred eighty-nine women diagnosed with GDM were enrolled and followed up at 6–12 weeks after delivery. A 75 g oral glucose tolerance test (OGTT) and lipid levels were performed during mid-trimester and the early postpartum period. Participants were divided into the normal lipid group and dyslipidemia group according to postpartum lipid levels. Demographic and metabolic parameters were analyzed. Multiple logistic regression was performed to analyze the potential predictors for early postpartum dyslipidemia. A receiver operating characteristic curve (ROC) was calculated to determine the cut-off values. Results A total of 38.5% of the 589 women developed dyslipidemia in early postpartum and 60% of them had normal glucose metabolism. Delivery age, systolic blood pressure (SBP), glycated hemoglobin (HbA1c) and low-density lipoprotein cholesterol (LDL-C) were independent predictors of early postpartum dyslipidemia in women with a history of GDM. The cut-offs of maternal age, SBP, HbA1c values, and LDL-C levels were 35 years, 123 mmHg, 5.1%, and 3.56 mmol/L, respectively. LDL-C achieved a balanced mix of high sensitivity (63.9%) and specificity (69.2%), with the highest area under the receiver operating characteristic curve (AUC) (0.696). When LDL-C was combined with age, SBP, and HbA1c, the AUC reached to 0.733. Conclusions A lipid metabolism evaluation should be recommended in women with a history of GDM after delivery, particularly those with a maternal age > 35 years, SBP > 123 mmHg before labor, HbA1c value > 5.1%, or LDL-C levels > 3.56 mmol/L in the second trimester of pregnancy.

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Section: Discussionsupporting

confidence: 93%

Early postpartum dyslipidemia and its potential predictors during pregnancy in women with a history of gestational diabetes mellitus

et al. 2020

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show abstract

“…The present ndings indicated that lipid levels during pregnancy were associated with an increased risk of dyslipidemia after delivery. This nding is consistent with two other studies that also showed a relationship between hypertriglyceridemia in pregnancy and at 6-12 months postpartum [25,26].…”

Section: Discussionsupporting

confidence: 93%

Early postpartum dyslipidemia and its potential predictors during pregnancy in women with a history of gestational diabetes mellitus

Pei

Xiao

Lai

et al. 2020

Preprint

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Background: This study aimed to analyze the incidence of early postpartum dyslipidemia and its potential predictors in women with a history of gestational diabetes mellitus (GDM).Methods: This was a retrospective study. 589 women diagnosed with GDM were enrolled and followed up at 6–12 weeks after delivery. A 75g oral glucose tolerance test (OGTT) and lipid levels were performed during mid-trimester and the early postpartum period. Participants were divided into the normal lipid group and dyslipidemia group according to postpartum lipid levels. Demographic and metabolic parameters were analyzed. Multiple logistic regression was performed to analyze the potential predictors for early postpartum dyslipidemia. A receiver operating characteristic curve (ROC) was calculated to determine the cut-off values.Results: A total of 38.5% of the 589 women developed dyslipidemia in early postpartum and 60% of them had normal glucose metabolism. Delivery age, systolic blood pressure (SBP), glycated hemoglobin (HbA1c) and low-density lipoprotein cholesterol (LDL-C) were independent predictors of early postpartum dyslipidemia in women with a history of GDM. The cut-offs of maternal age, SBP, HbA1c values, and LDL-C levels were 35 years, 123mmHg, 5.1%, and 3.56 mmol/L, respectively. LDL-C achieved a balanced mix of high sensitivity (63.9%) and specificity (69.2%), with the highest area under the receiver operating characteristic curve (AUC) (0.696). When LDL-C was combined with age, SBP, and HbA1c, the AUC reached to 0.733.Conclusions: A lipid metabolism evaluation should be recommended in women with a history of GDM after delivery, particularly those with a maternal age > 35 years, SBP > 123 mmHg before labor, HbA1c value > 5.1%, or LDL-C levels > 3.56 mmol/L in the second trimester of pregnancy.

show abstract

“…When LDL-C was combined with age, SBP and HbA1c, the AUC reached to 0.733. The present ndings indicated that lipids levels during pregnancy were associated with increased risk of dyslipidemia after delivery which was consistent with two other studies that also presented the relationship between hypertriglyceridemia in pregnancy and 6 to 12 months postpartum [22,23] .…”

Section: Discussionsupporting

confidence: 93%

Postpartum dyslipidemia and the potential predictors in women with history of gestational diabetes mellitus

Pei

Xiao

Lai

et al. 2020

Preprint

View full text Add to dashboard Cite

Aims/Introduction: To analyze the incidence of early postpartum dyslipidemia and the potential predictors among women with history of gestational diabetes mellitus (GDM).Materials and Methods: This was a retrospective study. 589 women diagnosed with GDM were recruited and followed up at 6-12 weeks after delivery. The general demographic and metabolic data during pregnancy were collected. Participants were divided into the normal lipid group and dyslipidemia group according to the postpartum lipid level. Demographic and metabolic parameters were compared. Multivariate logistic regression was performed to analyze the potential predictors for the early postpartum dyslipidemia. Receiver operating characteristic (ROC) curve was conducted to determine the cut-off values.Results: 38.5% of the 589 women developed dyslipidemia in early postpartum and 60% of them had normal glucose metabolism. Delivery age, systolic blood pressure (SBP), glycated hemoglobin (HbA1c) and low-density lipoprotein cholesterol (LDL-C) were independent predictors of early postpartum dyslipidemia in women with history of GDM. The cut-offs of maternal age, SBP, HbA1c and LDL-C were 35 years, 5.1% and 3.56 mmol/L, respectively. LDL-C achieved a balanced mix of high sensitivity（63.9%）and specificity(69.2%）with highest area under the receiver operating characteristic curve（AUC) (0.696). When LDL-C was combined with age, SBP and HbA1c, the AUC reached to 0.733.Conclusions: Women with history of GDM should be screened lipid metabolism after delivery, particularly those with maternal age >35 years, SBP>123mmHg before labor, HbA1c>5.1%, or LDL-C>3.56mmol/L in the second trimester of pregnancy.

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Previous Gestational Diabetes Increases Atherogenic Dyslipidemia in Subsequent Pregnancy and Postpartum

Cited by 12 publications

References 23 publications

Early postpartum dyslipidemia and its potential predictors during pregnancy in women with a history of gestational diabetes mellitus

Early postpartum dyslipidemia and its potential predictors during pregnancy in women with a history of gestational diabetes mellitus

Early postpartum dyslipidemia and its potential predictors during pregnancy in women with a history of gestational diabetes mellitus

Postpartum dyslipidemia and the potential predictors in women with history of gestational diabetes mellitus

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