Previous pregnancy loss: Risks related to severity of preterm delivery

Buchmayer, Susanne; Sparén, Pär; Cnattingius, Sven

doi:10.1016/j.ajog.2004.02.066

Cited by 59 publications

(34 citation statements)

References 22 publications

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“…Our results for preterm delivery are supported by the temporally reverse association, with previous studies reporting a higher risk of preterm birth among women with a history of miscarriage 141628293031. Possible shared pathways include cervical insufficiency and infections,141628293031 although these are speculative. There are a few clues in the literature suggesting that glucose metabolism abnormalities could increase both the risk of miscarriage and preterm delivery 32333435…”

Section: Discussionsupporting

confidence: 86%

Role of maternal age and pregnancy history in risk of miscarriage: prospective register based study

Magnus

Wilcox

Morken

et al. 2019

BMJ

439

227

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Objectives To estimate the burden of miscarriage in the Norwegian population and to evaluate the associations with maternal age and pregnancy history. Design Prospective register based study. Setting Medical Birth Register of Norway, the Norwegian Patient Register, and the induced abortion register. Participants All Norwegian women that were pregnant between 2009-13. Main outcome measure Risk of miscarriage according to the woman’s age and pregnancy history estimated by logistic regression. Results There were 421 201 pregnancies during the study period. The risk of miscarriage was lowest in women aged 25-29 (10%), and rose rapidly after age 30, reaching 53% in women aged 45 and over. There was a strong recurrence risk of miscarriage, with age adjusted odds ratios of 1.54 (95% confidence interval 1.48 to 1.60) after one miscarriage, 2.21 (2.03 to 2.41) after two, and 3.97 (3.29 to 4.78) after three consecutive miscarriages. The risk of miscarriage was modestly increased if the previous birth ended in a preterm delivery (adjusted odds ratio 1.22, 95% confidence interval 1.12 to 1.29), stillbirth (1.30, 1.11 to 1.53), caesarean section (1.16, 1.12 to 1.21), or if the woman had gestational diabetes in the previous pregnancy (1.19, 1.05 to 1.36). The risk of miscarriage was slightly higher in women who themselves had been small for gestational age (1.08, 1.04 to 1.13). Conclusions The risk of miscarriage varies greatly with maternal age, shows a strong pattern of recurrence, and is also increased after some adverse pregnancy outcomes. Miscarriage and other pregnancy complications might share underlying causes, which could be biological conditions or unmeasured common risk factors.

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Section: Discussionsupporting

confidence: 86%

Role of maternal age and pregnancy history in risk of miscarriage: prospective register based study

Magnus

Wilcox

Morken

et al. 2019

BMJ

439

227

View full text Add to dashboard Cite

show abstract

“…28 A previous SGA or preterm baby has been shown to be a risk for future stillbirth with the risk being greatest the more preterm and the smaller the previous baby. [30][31][32] We also found that a history of one or more previous induced abortions was associated with nearly a twofold increased risk of stillbirth. Other studies that investigated this association did not find an increased risk.…”

Section: Discussionmentioning

confidence: 71%

Fetal growth restriction and other risk factors for stillbirth in a New Zealand setting

McCowan

George-Haddad

Stacey

et al. 2007

Aust NZ J Obst Gynaeco

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“…In subsequent PTBs specific disorders (chorioamnionitis, PPROM, histological findings suggesting low placental blood flow) tend to reoccur [487]. The earlier in gestation a previous PTB has occurred the higher is the probability of a recurrent PTB [231,[233][234][235][236]238,530]. This seems to apply to previous singleton but not to previous twin pregnancies [234].…”

Section: Previous Ptbmentioning

confidence: 84%

“…It is not always clear from the literature whether the reported PTBs include iatrogenic PTB (as is usually the case with population-based studies) or represent spontaneous PTB only. Previous PTB is one of the most consistently reported risk factors for PTB [229][230][231][232][233][234][235][236][237][238][239] (see section 5.6.1.). A statistically significant association of a factor with PTB does not guarantee its usefulness as a predictor of PTB [24] (see section 6.1.…”

Section: Factors Associated With Ptbmentioning

confidence: 99%

See 1 more Smart Citation

Preterm Birth: A Review

Schellenberg

2006

CWHR

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Preterm birth at less than 37 weeks gestation is a substantial burden to the community, representing a major source of infant death, severe handicap, and suffering for both victims and their families. Despite considerable research, little progress has been made in its prevention, partly because preterm birth is the endpoint of a silent multifactorial syndrome which begins long before labour starts. Infectious inflammation often plays a central role, but maternal susceptibility is probably also critical. Although progestogen treatment is preventive in some women with a prior history of preterm birth this will have little impact on the overall preterm birth rate unless effective treatment can be used in a much larger population of at risk women. An accurate screening test to identify such women is needed. The discovery of a screening test and of novel treatments requires a better understanding of the underlying biomolecular events. This paper gives an overview of the physiology and molecular biology of normal and abnormal pregnancy and parturition, the causes and consequences of preterm birth, and the difficulties of predicting and preventing preterm birth.

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Previous pregnancy loss: Risks related to severity of preterm delivery

Cited by 59 publications

References 22 publications

Role of maternal age and pregnancy history in risk of miscarriage: prospective register based study

Role of maternal age and pregnancy history in risk of miscarriage: prospective register based study

Fetal growth restriction and other risk factors for stillbirth in a New Zealand setting

Preterm Birth: A Review

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