Previous pulmonary tuberculosis enhances the risk of lung cancer: systematic reviews and meta-analysis

Abdeahad, Hossein; Salehi, Maryam; Yaghoubi, Atieh; Aalami, Amir Hossein; Aalami, Farnoosh; Soleimanpour, Saman

doi:10.1080/23744235.2021.2006772

Cited by 19 publications

(18 citation statements)

References 68 publications

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“…However, the obvious increase or continuous increase of CEA level should be paid more attention to in clinic ( 14 ). Adenocarcinoma was the most common pathological type in our lung cancer group (68%), which was similar to earlier studies ( 15 , 16 ). Meanwhile, adenocarcinoma is the most common type of lung cancer with elevated CEA levels, which may explain the higher CEA levels in our group of lung cancer patients than in the control group.…”

Section: Discussionsupporting

confidence: 92%

The value of chest computed tomography in evaluating lung cancer in a lobe affected by stable pulmonary tuberculosis in middle-aged and elderly patients: A preliminary study

Long

Zhou

et al. 2022

Front. Oncol.

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IntroductionLung cancer can be masked by coexisting stable tuberculosis lesions, which may result in delayed lung cancer diagnosis and treatment. Information about pulmonary tuberculosis patients who are at high-risk of developing lung cancer is scarce. We aimed to examine the value of chest computed tomography (CT) in evaluating lung cancer in a lobe affected by stable pulmonary tuberculosis in middle-aged and elderly patients.MethodsIn this single-centered, retrospective, observational study, we enrolled 41 middle-aged and elderly patients with pulmonary tuberculosis who developed lung cancer in the same lobe from January 30, 2011 to December 30, 2020. Comparisons of the clinical and chest CT data were made with age-matched and sex-matched control groups of patients with stable pulmonary tuberculosis but no lung cancer diagnosis (n = 38).ResultsSeventeen patients in the lung cancer group (41%) were initially misdiagnosed. Compared to lesions in the control group, lesions in the lung cancer group were significantly more likely to demonstrate the following CT features: large size, vessel convergence, lobulation, spiculation, spinous protuberance, bronchial obstruction or stenosis, vacuolation, ground-glass opacification, heterogeneous or homogeneous enhancement, and gradual increase in size. Nodular enlargement showed the best diagnostic performance in the diagnosis of lung cancer in a lobe affected by tuberculosis (area under the receiver operating characteristic curve = 0.974; P <0.001; accuracy = 98.2%; sensitivity =94.7%; specificity = 100%).ConclusionChest CT might play an important role in early diagnosis of lung cancer in a lobe affected by tuberculosis. Regular CT re-examination is necessary in continuous controls monitoring of patients with stable pulmonary tuberculosis. The study indicates necessity of prospective study in this field.

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Section: Discussionsupporting

confidence: 92%

The value of chest computed tomography in evaluating lung cancer in a lobe affected by stable pulmonary tuberculosis in middle-aged and elderly patients: A preliminary study

Long

Zhou

et al. 2022

Front. Oncol.

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“…More recent systematic reviews found similar results in pulmonary [11,40] and non-pulmonary cancers [12] post-TB. In these studies, pooled risk of lung cancer ranged from 1.96 to 2.17 [11,12,40]. However, these systematic reviews all included studies with self-report data, which carry a critically high risk of recall bias.…”

Section: Discussionsupporting

confidence: 53%

“…They also found that the risk of lung cancer was over 10 times greater in the first 5 years following TB diagnosis, remaining elevated for more than 20 years after TB [39]. More recent systematic reviews found similar results in pulmonary [11,40] and non-pulmonary cancers [12] post-TB. In these studies, pooled risk of lung cancer ranged from 1.96 to 2.17 [11,12,40].…”

Section: Discussionmentioning

confidence: 74%

“…Moreover, people with TB are disproportionately affected by risk factors for malignancy such as smoking, immune suppression, and alcohol misuse [10]. Recent systematic reviews have shown an association between TB and both pulmonary [11] and non-pulmonary cancers [12]. Despite this link, there are currently no guidelines for cancer screening in TB populations.…”

Section: Introductionmentioning

confidence: 99%

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Tuberculosis and risk of cancer: A systematic review and meta-analysis

et al. 2022

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Introduction Cancer is a major cause of death among people who experience tuberculosis (TB), but little is known about its timing and incidence following TB treatment. Our primary objectives were to estimate the pooled risk of all and site-specific malignancies in people with TB compared to the general population or suitable controls. Our secondary objective was to describe the pooled risk of cancer at different time points following TB diagnosis. Methods This study was prospectively registered (PROSPERO: CRD42021277819). We systematically searched MEDLINE, Embase, and the Cochrane Database for studies published between 1980 and 2021. We included original observational research articles that estimated cancer risk among people with TB compared to controls. Studies were excluded if they had a study population of fewer than 50 individuals; used cross-sectional, case series, or case report designs; and had a follow-up period of less than 12 months. Random-effects meta-analysis was used to obtain the pooled risk of cancer in the TB population. Results Of the 5,160 unique studies identified, data from 17 studies were included. When compared to controls, the pooled standardized incidence ratios (SIR) of all cancer (SIR 1.62, 95% CI 1.35–1.93, I2 = 97%) and lung cancer (SIR 3.20, 95% CI 2.21–4.63, I2 = 90%) was increased in the TB population. The pooled risk of all cancers and lung cancer was highest within the first year following TB diagnosis (SIR 4.70, 95% CI 1.80–12.27, I2 = 99%) but remained over five years of follow-up. Conclusions People with TB have an increased risk of both pulmonary and non-pulmonary cancers. Further research on cancer following TB diagnosis is needed to develop effective screening and early detection strategies. Clinicians should have a high index of suspicion for cancer in people with TB, particularly in the first year following TB diagnosis.

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“…The coexistence of some medical conditions and diseases especially tuberculosis (TB) also reported to be associated in the pathogenesis of LC. The incidence and risk for the development of LC have been reported to be increased in patients with both latent TB and active TB [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Incidence and Risk of Lung Cancer in Tuberculosis Patients, and Vice Versa: A Literature Review of the Last Decade

Bhowmik

Mohanto

Sarker

et al. 2022

BioMed Research International

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Background. The incidence and risk of both lung cancer (LC) and tuberculosis (TB) are increasing rapidly. These two diseases frequently exist together and can influence the incidence and risk of each other. The aim of the current review was to summarize the incidence and risk of LC in TB patients, and vice versa, short out research gap, and contemplate future research perspectives. Methodology. PubMed and Scopus databases, and Google Scholar search engine were searched for epidemiological studies that investigated the incidence and risk of TB and LC, published since January 2011 to April 2022, and written in English. We used the searching keyword “tuberculosis” combined with “lung cancer” and associated medical subject heading (MeSH) to retrieve eligible research articles. We retrieved information’s regarding the diagnosis of TB and LC, confounders, the associations of TB and LC, and incidence and risks of each other. Results. We found higher incidence rate and risks (1.64 to 6 times higher) of LC in TB patients in comparison to non-TB participants. However, the incidence rate and risks of TB in LC patients were comparatively low. Male patients were exhibited higher risks than female. The medical comorbidities, smoking habits, and age can also influence the associations and risks of LC in TB patients or vice versa. Conclusion. Our summarized studies might suggest that existing active TB may increase the incidence and risk of LC. However, large prospective cohort study is warranted to explore the real scenario worldwide.

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Previous pulmonary tuberculosis enhances the risk of lung cancer: systematic reviews and meta-analysis

Cited by 19 publications

References 68 publications

The value of chest computed tomography in evaluating lung cancer in a lobe affected by stable pulmonary tuberculosis in middle-aged and elderly patients: A preliminary study

The value of chest computed tomography in evaluating lung cancer in a lobe affected by stable pulmonary tuberculosis in middle-aged and elderly patients: A preliminary study

Tuberculosis and risk of cancer: A systematic review and meta-analysis

Incidence and Risk of Lung Cancer in Tuberculosis Patients, and Vice Versa: A Literature Review of the Last Decade

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