Previously Unidentified Single Nucleotide Polymorphisms in HIV/AIDS Cases Associate with Clinical Parameters and Disease Progression

Анохин, В. А.; Бахтеева, Л Б; Хасанова, Г. Р.; Khaiboullina, Svetlana F.; Martynova, Ekaterina; Tillett, Richard L.; Schlauch, Karen; Lombardi, Vincent; Rizvanov, Albert A.

doi:10.1155/2016/2742648

Cited by 16 publications

(16 citation statements)

References 75 publications

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“…[ 52 ] In an Omani cohort, [ 55 ] the relationship between TLR4 (1063A/G, 1363C/T) gene polymorphism and the CD4 and CD8 cell counts and viral load was not found. In the studies of TLR7 gene polymorphisms, Oh et al [ 44 ] showed TLR 7 rs179008 is associated high viral loads and lower baseline CD4 T-cell counts, which was consistent with Anokhin et al, [ 56 ] but inconsistent with Said et al [ 57 ] TLR8 rs3764880 was conferred a significantly protective effect regarding progression of the disease. [ 45 ] The results reporting of the influence of the TLR9 rs352140 on disease progression are contradictory.…”

Section: Resultsmentioning

confidence: 82%

Association of toll-like receptor polymorphisms with acquisition of HIV infection and clinical findings

Shi

Sun³

et al. 2020

Medicine

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Background: To find the relationship between toll-like receptor (TLR) gene variants and human immunodeficiency virus (HIV) infection and clinical findings, which could inform clinical decisions and vaccination strategies. Method: Four databases were searched for articles that were published on or before Jul.1, 2020. Review Manager 5.3 software was applied to perform meta-analysis to explore. Results: A total of 10 studies involving 20 genes, 3697 cases, and 6498 controls were included in this systematic review. TLR2 –196 to –174 Ins/Del (odds ratio [OR] = 1.562; P = .002), TLR4 rs4986790 (OR = 2.05; P = .002), TLR3 rs3775291 (OR = 0.25; P = .03), TLR7 rs179008 ( P = .002), TLR7 rs2074109 (OR = 0.27, P = .019) were found associated with HIV infection. TLR2 –196 to –174, TLR4 rs4986790, TLR7 rs179008, TLR8 rs3764880, TLR9 rs352140 were found associated with clinical findings of HIV infection. We identified 5 case-control studies in meta-analysis, involving 695 cases and 729 controls on TLR7 rs179008 polymorphism, totaling 652 cases and 614 controls on TLR9 rs352140 polymorphism. In meta-analysis, we employed various genetic models. The T allele of TLR7 rs179008 was conferred the risk of HIV infection (T vs A: OR = 1.25, P A = .02). An increased risk of HIV infection was found for individuals with the TLR9 rs352140 GG genotype (GG vs AA: OR = 1.50, P A = .04). Conclusions: The systematic review indicated that TLR7 rs179008 T allele provides risk effects for HIV infection. TLR9 rs352140 GG genotype may associate with HIV infection.

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Section: Resultsmentioning

confidence: 82%

Association of toll-like receptor polymorphisms with acquisition of HIV infection and clinical findings

Shi

Sun³

et al. 2020

Medicine

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“…Genome-wide association studies (GWAS) is a powerful approach to unravel the genetics behind complex diseases [59]. In HIV research, GWAS has identified a number of SNPs associated with different forms of HIV progression [60]. The first GWAS in the HIV context was in the HLA class I locus that confirmed a major effect of HLA-B*57 in reducing viral load [61].…”

Section: Discussionmentioning

confidence: 99%

Effects of the killer immunoglobulin–like receptor (KIR) polymorphisms on HIV acquisition: A meta-analysis

Chaisri¹,

Pabalan²,

Tabunhan³

et al. 2019

PLoS ONE

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BackgroundGenetic involvement of Killer Immunoglobulin-like Receptor (KIR) polymorphisms and Human Immunodeficiency Virus (HIV)-exposed seronegative (HESN) compared to HIV-infected (HIVI) individuals has been reported. However, inconsistency of the outcomes reduces precision of the estimates. A meta-analysis was applied to obtain more precise estimates of association.MethodsA multi-database literature search yielded thirteen case-control studies. Risks were expressed as odds ratios (ORs) and 95% confidence intervals (CIs) with significance set at a two-tailed P-value of ≤ 0.05. We used two levels of analyses: (1) gene content that included 13 KIR polymorphisms (2DL1-3, 2DL5A, 2DL5B, 2DS1-3, 2DS4F, 2DS4D, 2DS5, 3DL1 and 3DS1); and (2) 3DL1/S1 genotypes. Subgroup analysis was ethnicity-based (Caucasians, Asians and Africans). Outlier treatment was applied to heterogeneous effects which dichotomized the outcomes into pre-outlier (PRO) and post-outlier (PSO). Multiple comparisons were addressed with the Bonferroni correction.ResultsWe generated 52 and 18 comparisons from gene content and genotype analyses, respectively. Of the 70 comparisons, 13 yielded significant outcomes, two (indicating reduced risk) of which survived the Bonferroni correction (Pc). These protective effects pointed to the Caucasian subgroup in 2DL3 (OR 0.19, 95% CI 0.09, 0.40, Pc < 10−3) and 3DS1S1 (OR 0.37, 95% CI 0.24, 0.56, Pc < 10−3). These two PSO outcomes yielded effects of increased magnitude and precision, as well as raised significance and deemed robust by sensitivity analysis. Of the two, the 2DL3 effect was improved with a test of interaction (Pc interaction < 10−4).ConclusionMultiple meta-analytical treatments presented strong evidence of the protective effect (up to 81%) of the KIR polymorphisms (2DL3 and 3DS1S1) among Caucasians. The Asian and African outcomes were inconclusive due to the low number of studies.

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“…OAS2 and OAS3) [109]. In contrast, other SNPs identified in OAS2 and OAS3 genes and in the TRIM5 gene were associated with a slower progression of disease [109]. Several studies have reported controversial results on the influence of retroviral restriction factor SNPs (e.g.…”

Section: Host Factorsmentioning

confidence: 99%

“…Additionally, SNPs associated with progression from HIV-1 infection to AIDS were identified in two 2′-5′-OAS genes (e.g. OAS2 and OAS3) [109]. In contrast, other SNPs identified in OAS2 and OAS3 genes and in the TRIM5 gene were associated with a slower progression of disease [109].…”

Section: Host Factorsmentioning

confidence: 99%

“…IFNα, IFNβ, IFNκ, IFNε, IFNω) or "pseudo"-genes (13 different IFNα subtypes), numerous type I IFN signaling pathway components and ISGs [16]. However, several studies have pointed out the importance of SNP related to the type I IFN pathways on the clinical outcome of HIV-1 disease [103][104][105][106][107][108][109][110][111][112][113][114][115][116][117]. Rapid progression of HIV-1 infection, altered viral load and CD4T cell count were associated with TLR9 polymorphisms [103][104][105].…”

Section: Host Factorsmentioning

confidence: 99%

See 1 more Smart Citation

Type I interferon and HIV: Subtle balance between antiviral activity, immunopathogenesis and the microbiome

Scagnolari

Antonelli

2018

Cytokine & Growth Factor Reviews

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Type I interferon (IFN) response initially limits HIV-1 spread and may delay disease progression by stimulating several immune system components. Nonetheless, persistent exposure to type I IFN in the chronic phase of HIV-1 infection is associated with desensitization and/or detrimental immune activation, thereby hindering immune recovery and fostering viral persistence. This review provides a basis for understanding the complexity and function of IFN pleiotropic activity in HIV-1 infection. In particular, the dichotomous role of the IFN response in HIV-1 immunopathogenesis will be discussed, highlighting recent advances in the dynamic modulation of IFN production in acute versus chronic infection, expression signatures of IFN subtypes, and viral and host factors affecting the magnitude of IFN response during HIV-1 infection. Lastly, the review gives a forward-looking perspective on the interplay between microbiome compositions and IFN response.

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Previously Unidentified Single Nucleotide Polymorphisms in HIV/AIDS Cases Associate with Clinical Parameters and Disease Progression

Cited by 16 publications

References 75 publications

Association of toll-like receptor polymorphisms with acquisition of HIV infection and clinical findings

Association of toll-like receptor polymorphisms with acquisition of HIV infection and clinical findings

Effects of the killer immunoglobulin–like receptor (KIR) polymorphisms on HIV acquisition: A meta-analysis

Type I interferon and HIV: Subtle balance between antiviral activity, immunopathogenesis and the microbiome

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