Prevotella: An insight into its characteristics and associated virulence factors

Sharma, Geetika; Garg, Nancy; Hasan, Shamimul; Shirodkar, Sheetal

doi:10.1016/j.micpath.2022.105673

Cited by 40 publications

(28 citation statements)

References 255 publications

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“…Prevotella salivae is an anaerobic gram-negative bacillus, commonly associated with oral and gastrointestinal infections, chronic osteomyelitis, bite-related infections, or rheumatoid infections. This bacterium can produce beta-lactamase, making Ceftazidime (cephalosporin antibiotic) a poor option, for this reason, metronidazole was started, the recommended antibiotic for empiric uses in these cases [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Under-Recognized Pathogens in Peritoneal Dialysis Associated-Peritonitis: The Importance of Early Detection

Domingues¹,

Furtado²,

Delgado-Valerio³

et al. 2023

Cureus

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Peritoneal dialysis-associated-peritonitis remains a major concern, increasing patient morbidity and mortality. Empirical antibiotics should be quickly started to allow a rapid resolution of symptoms and preservation of the peritoneal membrane.We report a case of peritoneal dialysis-associated-peritonitis due to Prevotella salivae and Corynebacterium jeikeium, in a 51-year-old male. Suspected peritonitis led to an immediate prescription of vancomycin and ceftazidime, with no clinical improvement. Prevotella is difficult to identify in culture since it's a gramnegative anaerobic bacterium, so metronidazole administration was delayed over days.New diagnostic techniques have been explored for the early diagnosis of peritonitis, including polymerase chain reaction (PCR) for bacterial DNA fragments. A multiplex PCR panel that includes Prevotella, already available for other applications, could be an advantage in cases like this.

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Section: Discussionmentioning

confidence: 99%

Under-Recognized Pathogens in Peritoneal Dialysis Associated-Peritonitis: The Importance of Early Detection

Domingues¹,

Furtado²,

Delgado-Valerio³

et al. 2023

Cureus

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“…Lipopolysaccharides on the outer membrane of Prevotella can regulate the p38 MAPK, JAK-STAT, and NF-kB signaling pathways (Sharma et al, 2022), and thus participate in cell growth, apoptosis, and death (Beg and Baltimore, 1996;Yosimichi et al, 2001;Lu et al, 2008). This suggests that Bacteroides and Prevotella may influence the occurrence of hypothyroidism during pregnancy through the cell growth and death pathways.…”

Section: Discussionmentioning

confidence: 99%

“…Bacteroides have been shown to facilitate peroxisome proliferator activated receptor-γ-mediated alterations in nuclear factor kappa B (NF-κB) activity ( Li et al., 2021 ), and the dysregulation of NF-κB signaling leads to abnormal cell proliferation and resistance to programmed cell death signals ( Beg and Baltimore, 1996 ). Lipopolysaccharides on the outer membrane of Prevotella can regulate the p38 MAPK, JAK-STAT, and NF-κB signaling pathways ( Sharma et al., 2022 ), and thus participate in cell growth, apoptosis, and death ( Beg and Baltimore, 1996 ; Yosimichi et al., 2001 ; Lu et al., 2008 ). This suggests that Bacteroides and Prevotella may influence the occurrence of hypothyroidism during pregnancy through the cell growth and death pathways.…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, our correlation analysis revealed that the abundance of Prevotella was positively associated with Th1 cells, the Th1/Th2 ratio, and the TNF-α level. Lipopolysaccharides of Prevotella , a potent inducer of the inflammatory response, can induce the increase of several pro-inflammatory cytokines, such as TNF-α and IL-6 ( Sharma et al., 2022 ). Prevotella can induce Th1 polarization and inhibit Th2 polarization through dendritic cells, thus causing the Th1/Th2 balance to shift to the left ( van Teijlingen et al., 2020 ).…”

Section: Discussionmentioning

confidence: 99%

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Correlation between the intestinal microflora and peripheral blood Th1/Th2 balance in hypothyroidism during the first half of pregnancy

Ban

et al. 2023

Front. Cell. Infect. Microbiol.

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ObjectiveThis study aimed to investigate the relationship between intestinal microflora characteristics and the peripheral blood T helper cell (Th)1/Th2 balance in patients with hypothyroidism during the first half of pregnancy.MethodsThe Th1/Th2 ratios in the peripheral blood of pregnant women in the hypothyroidism and control groups were determined using flow cytometry. The cytometric bead array assay was used to determine the serum levels of interleukin-2 (IL-2), IL-4, IL-6, IL-10, tumor necrosis factor (TNF)-α, and interferon (IFN)-γ. Moreover, 16S rRNA amplicon sequencing was used to determine the intestinal microbial composition in the two groups. Finally, the relationships between intestinal microflora, Th1/Th2 cells, cytokines, and clinical indicators were analyzed.ResultsC-reactive protein levels were higher in the hypothyroidism group than in the control group. In contrast to the control group, the hypothyroidism group showed an increase in Th1 cells and the Th1/Th2 ratio, and a decrease in Th2 cells. The hypothyroidism group had higher serum IL-2, TNF-α, and IFN-γ levels, and lower IL-10 levels, than the control group. The richness of the intestinal microflora in the hypothyroidism group increased whereas the diversity decreased. The linear discriminant analysis effect size revealed that the hypothyroidism group had a higher abundance of Prevotella and Faecalibacterium, but a lower abundance of Bacteroides, compared to the control group. Prevotella was positively correlated with Th1 cells, the Th1/2 ratio, and TNF-α. Bacteroides was positively correlated with Th2 cells and IL-10, but negatively correlated with Th1 cells, the Th1/2 ratio, TNF-α, and IFN-γ. The thyroid peroxidase antibody level was directly proportional to TNF-α.ConclusionA Th1/Th2 imbalance occurs in patients with hypothyroidism during the first half of pregnancy. Disorders of the intestinal microflora may lead to hypothyroidism during pregnancy by affecting the Th1/Th2 balance.

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“…is a common group of obligate anaerobic bacteria in healthy humans. It mainly exists on the surface of mucosa and has been isolated from oral cavity, gastrointestinal and urogenital tract mucosa [4] . In 1982, Holdeman et al rst isolated a pathogenic bacterium from the oral cavity of a patient with periodontitis, attributed it to the genus Bacteroides and named Bacteroides oralis [5] .…”

Section: Discussionmentioning

confidence: 99%

A Case Report of Brain abscess due to Prevotella oris and Review of the Literature

et al. 2023

Preprint

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Background Brain abscess caused by Prevotella oris is rarely reported. Here we described a case of brain infection from Prevotella oris detected by the metagenomic next-generation sequencing (mNGS). Case presentation A 63-year-old man with no medical history reported headache in the right frontotemporal region, fever, and intermittent diplopia. Magnetic resonance imaging (MRI) revealed abnormal signals and enhancement changes in sellar region, superior sellar region. mNGS testing showed that the cerebrospinal fluid collected from spinal was detected positively for Prevotella oris. After receiving the combined treatment of antibiotic therapy, the patient recovered well. Conclusion We review the relevant literature and try to summarize the characteristics and prognosis of bacterial infection, to provide ideas for clinicians to diagnose and treat disease.

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Prevotella: An insight into its characteristics and associated virulence factors

Cited by 40 publications

References 255 publications

Under-Recognized Pathogens in Peritoneal Dialysis Associated-Peritonitis: The Importance of Early Detection

Under-Recognized Pathogens in Peritoneal Dialysis Associated-Peritonitis: The Importance of Early Detection

Correlation between the intestinal microflora and peripheral blood Th1/Th2 balance in hypothyroidism during the first half of pregnancy

A Case Report of Brain abscess due to Prevotella oris and Review of the Literature

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