Pri-miR-34b/c rs4938723 polymorphism contributes to acute lymphoblastic leukemia susceptibility in Chinese children

Tong, Na; Chu, Haiyan; Wang, Meilin; Xue, Yue; Du, Mulong; Lu, Lingling; Zhang, Heng; Wang, Feng; Fang, Yongjun; Li, Jie; Wu, Dongmei; Zhang, Zhengdong; Sheng, Xiaojing

doi:10.3109/10428194.2015.1092528

Cited by 29 publications

(21 citation statements)

References 27 publications

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“…The rs4938723 polymorphism has been shown to influence the cell cycle of downstream cells, as well as induce changes in the expression of key genes in the apoptotic pathway, thereby influencing cancer susceptibility. Several studies have reported a significant association between the rs4938723 polymorphism and risk of malignant tumors such as acute lymphoblastic leukemia, cervical cancer, papillary thyroid carcinoma, gastric cancer, esophageal squamous cell carcinoma, renal cell cancer, and colorectal cancer (Oh et al, 2014;Zhang et al, 2014a,b;Chen et al, 2015;Pan et al, 2015;Tong et al, 2016;Yuan et al, 2016). A previous large-scale case-control study comprising 1109 esophageal squamous cell carcinoma patients and 1275 healthy subjects reported a correlation between the GG genotype of miR-34b/c and a significantly reduced risk of esophageal squamous cell carcinoma in a Chinese population (Zhang et al, 2014a).…”

Section: Discussionmentioning

confidence: 99%

Association between polymorphisms in the promoter region of pri-miR-34b/c and risk of hepatocellular carcinoma

et al. 2016

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Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths worldwide. MicroRNA-34 (miR-34) gene plays a key role in altering the apoptotic cycle and pathways of downstream cells, and therefore influences carcinogenesis. In this case-control study, we assessed the role of the pri-miR-34b/c rs4938723 polymorphism in HCC risk. The pri-miR-34b/c polymorphic genotype was determined in 286 patients with HCC and 572 controls using polymerase chain reaction-restriction fragment length polymorphism. The male gender (X = 12.95, P < 0.001), regular alcohol consumption (X = 16.81, P < 0.001), and a family history of cancer (X = 11.88, P = 0.001) were associated with HCC risk. However, the age (t = 1.19, P = 0.12) and tobacco smoking habit (X = 0.64, P = 0.42) of HCC patients were comparable to those of the controls. The TC (adjusted OR = 1.46, 95%CI = 1.06-2.01) and CC (adjusted OR = 3.07, 95%CI = 1.77-5.34) genotypes of pri-miR-34b/c rs4938723 were correlated with a higher risk of HCC compared to the TT genotype. Moreover, the TC+CC genotype was correlated with an increased risk of HCC compared to the TT genotype (adjusted OR = 1.64, 95%CI = 1.21-2.22). In the recessive model, the CC genotype of pri-miR-34b/c rs4938723 was significantly correlated with an elevated risk of HCC compared to the TT+TC genotype (adjusted OR = 2.50, 95%CI = 1.49-4.22). Further large-scale and multi-center studies are required to confirm these results.

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Section: Discussionmentioning

confidence: 99%

Association between polymorphisms in the promoter region of pri-miR-34b/c and risk of hepatocellular carcinoma

et al. 2016

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“…A meta-analysis performed by Wang et al (38) suggests that the pri-miR-34b/c rs4938723 polymorphism may be associated with the risk of cancer, including nasopharyngeal cancer, osteosarcoma and renal cell cancer. Tong et al (39) reported that the rs4938723 variant significantly decreased the risk of Chinese childhood acute lymphoblastic leukemia.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the pri-miR-34b/c rs4938723 polymorphism and its association with breast cancer risk

et al. 2016

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Abstract. MicroRNAs (miRNAs or miRs) are a family of small non-coding RNAs that function as oncogenes or tumor suppressor genes. Recent evidence suggests that the pri-miR-34b/c rs4938723 variant is associated with the development of cancer. At present, there is an inconsistent association between the single-nucleotide polymorphism in pri-miR-34b/c and cancer in the limited studies. The present study is a case-control investigation, with 263 breast cancer (BC) patients and 221 control women, which examined the potential association of the pri-miR-34b/c rs4938723 polymorphisms with BC susceptibility. The polymorphisms were genotyped by the polymerase chain reaction restriction fragment length polymorphism method. No significant association between the pri-miR-34b/c rs4938723 variant and BC was identified [TC vs. TT: Odds ratio (OR), 0.87; 95% confidence interval (CI), 0.60-1.26; P=0.506; CC vs. TT: OR, 1.22; 95% CI, 0.61-2.47; P= 0.600; TC+CC vs. TT: OR, 0.91; 95% CI, 0.64-1.31; P= 0.648; CC vs. TT+TC: OR, 1.32; 95% CI, 0.67-2.59; P= 0.498; C vs. T: OR, 0.99; 95% CI, 0.75-1.31; P= 0.986]. However, a significant association was observed between the pri-miR-34b/c rs4938723 genotypes and clinicopathological characteristics, such a grade, progesterone receptor and human epidermal growth factor receptor 2 status were observed (P<0.05). These findings suggest that the pri-miR-34b/c rs4938723 variant may not be a risk factor for the development of BC. IntroductionBreast cancer (BC), the most prevalent type of cancer in women, is a major public and global health problem and accounts for 14% of total annual cancer fatalities worldwide (1). Similarly, BC is the most common malignancy affecting Iranian women (2). Although the etiology of BC remains to be identified, genetic factors are shown to have important roles in the pathogenesis and progress of this malignancy (3-8).MicroRNAs (miRNAs or miRs) are a class of single-stranded non-coding RNA typically 17-25 nucleotides in length that have key roles in the regulation of cellular processes by targeting mRNAs for cleavage or translational repression (9,10). They regulate the expression of genes at the post-transcriptional level by targeting the 3' untranslated regions of mRNAs. Cumulative evidence suggests that the dysregulation of miRNA expression is involved in the tumorigenesis by acting as tumor suppressors or oncogenes (11-15). Single-nucleotide polymorphisms (SNPs) or mutations in miRNA genes can affect the miRNA biosynthesis and expression of target genes, therefore resulting in diverse functional consequences and thereby possibly representing potentially important biomarkers for the prognosis of cancer (7,(16)(17)(18).The pri-miR-34b/c gene resides in a CpG island within the intron of the B-cell translocation gene 4. Therefore, it is expected that pri-miR-34b/c is co-transcribed by either the promoter of the protein-coding gene or by its own transcription initiation region, as is the case with the majority of miRNAs, whether they are intergenic or located within the i...

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“…Other scholars suggested that miR-27a rs895819 polymorphism could affect the expression of its targeted gene ZBTB1038. And the promoter polymorphism of miR-34b/c rs4938723 could influence the transcription activity of miR-34b/c promoter, which therefore affect miRNA expression3940. As the three described polymorphisms of let-7e, miR-4795 and miR-365b are all located in the important promoter regions, we speculate that these miRNA SNPs may be associated with the downregulation of PGC expression, thus increasing gastric cancer risk.…”

Section: Discussionmentioning

confidence: 99%

Association of Polymorphisms in three pri-miRNAs that Target Pepsinogen C with the Risk and Prognosis of Gastric Cancer

Wu¹,

Xu²,

et al. 2017

Sci Rep

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We aimed to explore the associations of polymorphisms in three microRNAs (miRNAs) (let-7e rs8111742, miR-365b rs121224 and miR-4795 rs1002765) that target PGC with the risk and prognosis of gastric cancer/atrophic gastritis. Sequenom’s MassArray was used to genotype the miRNA polymorphisms in 724 gastric cancer cases, 862 atrophic gastritis cases and 862 controls in a Chinese population. We found that let-7e rs8111742 and miR-4795 rs1002765 were associated with the risk of gastric cancer in the H. pylori-positive subgroup. MiR-365b rs121224 was associated with the risk of intestinal-type gastric cancer in the alcohol consumption subgroup. Intestinal-type gastric cancer patients at Borrmann stages III-IV who carry the miR-365b rs121224 GG genotype had better prognosis compared with those who carry the CG or CC genotypes. MiR-365b rs121224 was associated with Lauren typing and TNM staging, in which the distribution of GG genotype carriers in intestinal-type gastric cancer and the TNM stage I-II subgroup was higher than that of CG or CC genotypes, which contrasted with the distribution in diffuse-type gastric cancer or TNM III-IV groups. These findings suggested that the polymorphisms in these miRNAs might be biomarkers for gastric cancer risk and prognosis, especially for populations infected with Helicobacter pylori or who consume alcohol.

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Pri-miR-34b/c rs4938723 polymorphism contributes to acute lymphoblastic leukemia susceptibility in Chinese children

Cited by 29 publications

References 27 publications

Association between polymorphisms in the promoter region of pri-miR-34b/c and risk of hepatocellular carcinoma

Association between polymorphisms in the promoter region of pri-miR-34b/c and risk of hepatocellular carcinoma

Evaluation of the pri-miR-34b/c rs4938723 polymorphism and its association with breast cancer risk

Association of Polymorphisms in three pri-miRNAs that Target Pepsinogen C with the Risk and Prognosis of Gastric Cancer

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