Priapism as the initial sign in hematologic disease: Case report and literature review

Priapism is a rare urological emergency. It is rarely a telltale sign of myeloid leukemia. We report two cases of acute myeloid leukemia in a child and chronic myeloid leukemia in a young adult presenting with priapism. Puncture irrigation of the corpora cavernosa followed by systemic treatment to lower the hyperviscosity of the blood due to leukemia provided optimal outcome. Prompt emergency management is required to lower the complication of erectile dysfunction.

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“…[ 1 ]. In the United States, ischemic priapism presents more commonly with an incidence of up to 5.34 per 100,000 men per year [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Unusual Presentation of Priapism Associated with Acute and Chronic Myeloid Leukemia in Two Patients: Emergency Management

Gaye

Thiam

Cassell

et al. 2020

Case Reports in Urology

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“…Well-documented hematological conditions causing priapism are hemolytic disorders (e.g., homozygous sickle cell disease); myeloproliferative neoplasms (e.g., chronic myeloid leukemia [CML] and polycythemia vera [PV]); acute leukemia (e.g., acute myeloblastic leukemia [AML] and acute lymphoblastic leukemia [ALL] with high counts); plasma cell disorders (e.g., myeloma and amyloidosis); and hypercoagulable states. Sickle cell disease is the most common hematological disorder, while CML is the most common leukemia associated with priapism [ 3 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported in patients with various non-malignant and malignant hematological disorders, including myeloproliferative neoplasms. Chronic myeloid leukemia (CML) is the most common myeloproliferative neoplasm (MPN) associated with priapism [ 1 – 3 ]. It is rarely reported as a complication in patients with essential thrombocythemia.…”

Section: Introductionmentioning

confidence: 99%

Essential Thrombocythemia Presenting with Recurrent Priapism: A Case Report and Review of Literature

et al. 2020

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“…However, in adults, priapism associated with leukemia may account for 1-5% of cases. In addition, priapism in leukemic patients is much more common among CML than acute leukemia patients [7] .…”

Section: Discussionmentioning

confidence: 99%

Discontinuation of treatment in a chronic myeloid leukemia patient caused priapism: A case report

2019

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Priapism is an unusual andrological emergency that requires urgent intervention. It is characterized by prolonged penile erection for more than 4 h not related to sexual excitation. It is classified into three main types:veno-occlusive (ischemic), arterial (non-ischemic) and stuttering priapism. Many causes can predispose to ischemic priapism including thalassemias, sickle cell anemia, hypercoagulable status, neoplastic syndromes, pelviabdominal tumors and use of some drugs and medications. However, in the majority of cases of ischemic priapism no cause could be identified. Chronic myeloid leukemia (CML) is a chronic myeloprolifertative tumor that is characterized by a variety of vague clinical manifestations. Priapism as a complication of CML is a rare clinical presentation. It may cause priapism as a result of hypercoagulability due to hyperleukocytosis. Here, in this report, the case of a known CML male patient who presented with venoocclusive priapism for about 16 h after abrupt discontinuation of his cytoreductive therapy is described. Thus, all medical staff, either (General practitioners) GPs or specialized in different fields of medicine, should be aware of priapism as an emergency and that early diagnosis and multidisciplinary management minimize the inevitable damage of the erectile corpora cavernosa as well as improving the outcome.

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Priapism as the initial sign in hematologic disease: Case report and literature review

Cited by 21 publications

References 20 publications

Unusual Presentation of Priapism Associated with Acute and Chronic Myeloid Leukemia in Two Patients: Emergency Management

Unusual Presentation of Priapism Associated with Acute and Chronic Myeloid Leukemia in Two Patients: Emergency Management

Essential Thrombocythemia Presenting with Recurrent Priapism: A Case Report and Review of Literature

Discontinuation of treatment in a chronic myeloid leukemia patient caused priapism: A case report

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