Priapism associated with risperidone: a case report, literature review and review of the South London and Maudsley hospital patients’ database

Paklet, Lise; Abe, Anne Mary; Olajide, Dele

doi:10.1177/2045125312464104

Cited by 20 publications

(20 citation statements)

References 46 publications

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“…For the typical antipsychotics, more cases have been reported with low potency agents, such as chlorpromazine, compared to the high potency agents, such as haloperidol, due to the level of alpha 1-adrenergic antagonism [2]. For the atypical antipsychotics, risperidone and ziprasidone have the highest antagonism at alpha 1 and olanzapine has the lowest [3]. However, there have been several published cases of priapism with other atypical antipsychotics with lower alpha 1-antagonism such as olanzapine, quetiapine, and clozapine [6].…”

Section: Discussionmentioning

confidence: 99%

“…Conservative management (observation, ice, and rest), corporal aspiration, injection of sympathomimetic agents, and, if the former treatments fail, surgical intervention are the treatment choices [4]. Alpha-1 adrenergic antagonism is thought to be the underlying mechanism of priapism [3]. With this case, we report a case of priapism caused by quetiapine in a patient diagnosed bipolar disorder, in euthymic state.…”

Section: Introductionmentioning

confidence: 96%

“…Medications, hematologic disorders, substances, malignancies, trauma, and metabolic conditions are several causes of this clinically urologic emergent condition [1,2]. Whether priapism left untreated, could lead to impotence and tissue necrosis even gangrene as a result of intracavernosal stasis and hypoxia [3]. Conservative management (observation, ice, and rest), corporal aspiration, injection of sympathomimetic agents, and, if the former treatments fail, surgical intervention are the treatment choices [4].…”

Section: Introductionmentioning

confidence: 99%

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Quetiapine-induced priapism

Özen¹,

Örüm²,

Kalenderoğlu³

et al. 2018

Med-Science

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Priapism is a urologic emergency characterized by a prolonged, persistent, and painful penile erection in the absence of sexual stimulation. The reports indicate that several conditions can cause priapism such as psychotropic medication. One of the mechanisms by which antipsychotics are believed to induce priapism is through alpha 1-antagonism. This case is of a 28-year-old male with a history of bipolar disorder with priapism related to quetiapine. In this case, the treatment of priapism includes discontinuation of the offending agent and drainage of the corpus cavernosum twice a day along with intracavernosal phenylephrine injections. Previous episodes of medication-induced priapism may increase the risk of priapism in patients afterwards. It is important to inform patients about the priapism that may occurs as a side effect of medications.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Quetiapine-induced priapism

Özen¹,

Örüm²,

Kalenderoğlu³

et al. 2018

Med-Science

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“…There are several causes of priapism including medications, hematologic disorders, substances, malignancies, trauma, and metabolic conditions [ 1 , 2 ], Table 1 . Priapism is considered a urologic emergency which, if left untreated, could lead to impotence and tissue necrosis [ 3 ]. The treatment of priapism includes conservative management (observation, ice, and rest), corporal aspiration, injection of sympathomimetic agents, and, if the above treatments fail, surgical intervention [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

A Case of Priapism with Risperidone

Ginory

Nguyen

2014

Case Reports in Psychiatry

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Priapism is a urologic emergency defined as a prolonged, possibly painful, penile erection. There are several known causes of priapism including psychotropic medications. One of the mechanisms by which antipsychotics are believed to induce priapism is through alpha-1 antagonism. This is case of a 50-year-old male with a history of schizophrenia with previous priapism related to trazodone, who presents with new onset priapism associated with risperidone. In this case, the treatment of priapism includes discontinuation of the offending agent and drainage of the corpus cavernosum twice along with intracavernosal phenylephrine injections. It is important to educate patients on priapism as a possible side effect of medications. It is also important to consider previous episodes of medication-induced priapism when prescribing psychotropic medications as this may increase the patient's future risk of priapism.

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“…Other drugs known to cause priapism rarely include sodium valproate [1] and risperidone [2], cited as single case-reports in the literature.…”

mentioning

confidence: 99%