Priapism in sickle‐cell disease; incidence, risk factors and complications – an international multicentre study

Adeyoju, Adebanji; Olujohungbe, Adebayo; Morris, Julie; Yardumian, A; Bareford, David; Akenova, A.; Akinyanju, O. O.; Cinkotai, K. I.; O'reilly, P. H.

doi:10.1046/j.1464-410x.2002.03022.x

Cited by 229 publications

(200 citation statements)

References 12 publications

Supporting

Mentioning

178

Contrasting

Unclassified

Order By: Relevance

“…In men with SCD, vaso-occlusion and recurrent testicular infarction may contribute to hypogonadism [122,123]. Erectile dysfunction has been reported in as many as 21% to 35% and is likely a sequela of recurrent episodes of priapism [124,125]. Osegbe et al demonstrated that adult males with SCD, not taking hydroxyurea, have lower sperm count, motility and The participants assigned to hydroxyurea treatment had lower annual rates of crises than the participants given placebo (median, 2.5 vs. 4.5 crises per year, P < 0.001).…”

Section: Reproductive Health In Adults With Scdmentioning

confidence: 99%

Evolution of sickle cell disease from a life‐threatening disease of children to a chronic disease of adults: The last 40 years

2015

View full text Add to dashboard Cite

Over the past 40 years, public health measures such as universal newborn screening, penicillin prophylaxis, vaccinations, and hydroxyurea therapy have led to an impressive decline in sickle cell disease (SCD)-related childhood mortality and SCD-related morbidity in high-income countries. We remain cautiously optimistic that the next 40 years will be focused on meeting current challenges in SCD by addressing chronic complications of SCD to reduce mortality and improve quality of life in a growing population of adults with SCD in high-income countries, while simultaneously decreasing the disparity of medical care between high and low-income countries.

show abstract

Section: Reproductive Health In Adults With Scdmentioning

confidence: 99%

Evolution of sickle cell disease from a life‐threatening disease of children to a chronic disease of adults: The last 40 years

2015

View full text Add to dashboard Cite

show abstract

“…Priapism, for example, is another complication resulting from sickle cell, as the corpora cavernosa of the penis are blood reservoirs prone to localized stasis, sickling, and obstruction of venous drainage [5,6]. The prevalence of this complication could be higher than previously described [7,8], as patients do not report short episodes or do not associate the symptoms with sickle disease [9][10][11], suggesting that better education of these patients is necessary.…”

Section: Introductionmentioning

confidence: 99%

Follow‐up of sickle cell disease patients with priapism treated by hydroxyurea

Saad¹,

Lajolo²,

Gilli³

et al. 2004

American J Hematol

View full text Add to dashboard Cite

Hydroxyurea is one of the most successfully used therapies for sickle cell disease. Results of many clinical trials point to hydroxyurea administration for patients with frequent painful crises and acute chest syndrome. Priapism is one of the complications that could be prevented by hydroxyurea, but there are few reports demonstrating the results. Since November 1993, hydroxyurea has been used in our clinic for preventing priapism in patients with stuttering or major attacks who are still capable of achieving intercourse on demand. Five patients were enrolled in the study, and 4 cases benefited by this treatment. After the initial treatment for the acute attack, all five patients developed stuttering priapism. Hydroxyurea was then introduced at the initial dose of 10 mg/kg, and as the hydroxyurea dosage increased, the number or length of priapism episodes decreased. One to two months after the maximal dose (20-35 mg/kg) was introduced, the episodes disappeared. In two patients, we were forced to administer over 30 mg hydroxyurea/kg to abort the episodes, and, in another patient, 25 mg/kg was necessary. All patients present normal sexual activity. Hydroxyurea was discontinued in two patients, but stuttering priapism reappeared. Hydroxyurea was then re-introduced, and priapism disappeared. One patient, using 20 mg hydroxyurea/kg, had a 6-year remission of priapism after hydroxyurea administration; however, he experienced stuttering priapism, 1 month before a major attack, that progressed to impotence. During that month, he did not seek medical attention. In conclusion, the data here presented suggests that hydroxyurea may prevent priapism attacks in sickle cell disease, probably at higher doses than usually prescribed for painful crisis prevention. Am.

show abstract

“…5 The lifetime probability for the development of clinically significant priapism is as high as 42% in men with SCD, and the rate of resultant ED exceeds 30%. 3,[6][7][8] Typically, there is a bimodal peak of incidence between 5 and 10 years in children and 20-50 years in adults. 9 By the time most men with SCD reach their twenties, greater than 75% of them will have already experienced their first episode of priapism, with the mean age of occurrence between 12 and 15 years old.…”

Section: Epidemiology Of Priapism and Patient Populations At Riskmentioning

confidence: 99%

“…9 By the time most men with SCD reach their twenties, greater than 75% of them will have already experienced their first episode of priapism, with the mean age of occurrence between 12 and 15 years old. 6,8,10,11 SCD is the most common etiology of priapism in childhood accounting for 63% of cases and is the primary etiology of ischemic priapism in 23% of adult cases. 12 The fact that SCD populations are affected to a greater degree by priapism emphasizes the public health significance of this problem and, more importantly, the need for education and preventive efforts in addressing solutions.…”

Section: Epidemiology Of Priapism and Patient Populations At Riskmentioning

confidence: 99%

“…13,14 These findings have been conveyed in other studies as well indicating the significance for education and prompt treatment. 6,8 Delays in treatment and repetitive episodes of stuttering priapism lead to cellular, molecular and morphological changes in the corpus cavernosum, which over time result in tissue injury that can accumulate developing into permanent ED. 15,16 In addition to the profound decrement in quality of life that results from having permanent ED, SCD patients that experience priapism have a fivefold greater risk of developing pulmonary hypertension, and thus, the comorbidities which follow.…”

Section: Epidemiology Of Priapism and Patient Populations At Riskmentioning

confidence: 99%

See 1 more Smart Citation

Medical management of ischemic stuttering priapism: a contemporary review of the literature

Levey¹,

Kutlu²,

Bivalacqua³

2011

Asian J Androl

View full text Add to dashboard Cite

Priapism is defined as a prolonged and persistent erection of the penis without sexual stimulation. This is a poorly understood disease process with little information on the pathophysiology of this erectile disorder. Complications from this disorder are devastating due to the irreversible erectile damage and resultant erectile dysfunction (ED). Stuttering priapism, though relatively rare, affects a high prevalence of men with sickle-cell disease (SCD) and presents a challenging problem with guidelines for treatment lacking or resulting in permanent ED. The mechanisms involved in the development of priapism in this cohort are poorly characterized; therefore, medical management of priapism represents a therapeutic challenge to urologists. Additional research is warranted, so we can effectively target treatments for these patients with prevention as the goal. This review gives an introduction to stuttering priapism and its clinical significance, specifically with regards to the patient with SCD. Additionally, the proposed mechanisms behind its pathophysiology and a summary of the current and future targets for medical management are discussed.

show abstract

Priapism in sickle‐cell disease; incidence, risk factors and complications – an international multicentre study

Cited by 229 publications

References 12 publications

Evolution of sickle cell disease from a life‐threatening disease of children to a chronic disease of adults: The last 40 years

Evolution of sickle cell disease from a life‐threatening disease of children to a chronic disease of adults: The last 40 years

Follow‐up of sickle cell disease patients with priapism treated by hydroxyurea

Medical management of ischemic stuttering priapism: a contemporary review of the literature

Contact Info

Product

Resources

About