Priapismo como presentación inicial de leucemia mieloide crónica

López, M. Allué; Martínez, A.; Regueiro, D. Pascual; Mateo, E. Mallén; Benedicto, A. Villanueva; Sanz, Libia

doi:10.1016/s0210-4806(04)73094-6

Cited by 27 publications

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“…Reserpine, one of the alkaloids of the Rauwolfia species, had been used for the management of hypertension, schizophrenia and psychiatric disorders[20] and even thought to be beneficial in cases of Huntington disease[21]. However, its use was discontinued because it caused extrapyramidal side effects such as orofacial dyskinesia and tremor[22].…”

Section: Introductionmentioning

confidence: 99%

Comparative effects of Rauwolfia vomitoria and chlorpromazine on social behaviour and pain

2011

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Background:Rauwolfia vomitoria has been used in Nigeria to manage psychiatric disorders despite orthodox medicine.Aims:This research was therefore aimed at comparing the effects of R. vomitoria, chlorpromazine and reserpine on social behaviour and pain in mice.Materials and Methods:Ninety male CD-1 mice (32 – 38g body weight) were grouped into 3 with 5 subgroups (n=6) each. Mice were given chlorpromazine (0.0, 0.25, 1.0, 2.0, 4.0 mg/kg i.p.), 30 minutes before testing and R. vomitoria (0.0, 0.25, 1.0, 2.0, 4.0 mg/kg, i.p.) and reserpine (0.0, 0.1, 0.4, 0.8, 1.6 mg/kg, i.p) 24 hours before testing. Nesting score assessed social behaviour while the tail flick and hot plate analgesiometers assessed pain.Results:Chlorpromazine dose-dependently decreased nesting score (F4,25 = 5.5660; p< 0.01), indicating decreased social behaviour (social loss) in the mice. Although R. vomitoria did not affect nesting score, reserpine decreased the nesting score (social loss). In the pain test, chlorpromazine did not alter tail flick latency but decreased hind paw lick latency in the hot plate at 2.0 and 4.0 mg/kg (p< 0.01), indicating increased pain sensitivity at these doses which may indirectly increase social withdrawal and thus aggravating depression. R. vomitoria however, increased tail flick and hind paw lick latencies in the hot plate test (p< 0.05) indicating decreased pain sensitivity. Reserpine, like R. vomitoria, increased latency of hind paw lick in the hot plate.Conclusion:R. vomitoria has a high potential as an antipsychotic and may have advantage over chlorpromazine; it is not necessary to isolate active components from this herb.

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Section: Introductionmentioning

confidence: 99%

Comparative effects of Rauwolfia vomitoria and chlorpromazine on social behaviour and pain

2011

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“…Even as the former was a substance of chemical synthesis, the latter was an alkaloid having a natural origin, obtained from the root of Rauwolfia serpentina . [7] Both these drugs have helped the onset of the psychopharmacological era in the treatment of schizophrenia,[8] although the role of Rauwolfia is often not discussed. Commonly known as sarpagandha (Sanskrit name), Rauwolfia has been used medicinally in ancient India and has found mention in the Hindu texts dating from around 500 BC, including the Charaka Samhita .…”

Section: Role Of Rauwolfiamentioning

confidence: 99%

“…[1617] Although the utility of Rauwolfia in cardiovascular disorders has been premiered by Vakil, its utility in mental illnesses can be said to have been popularized by Dr. R. A. Hakim from Ahmedabad, Gujarat, who studied the effects of ‘ Siledin ’, a mixture of medicinal plants, including Rauwolfia , and found it effective in schizophrenic and manic-depressive disorders. [818]…”

Section: Role Of Rauwolfiamentioning

confidence: 99%

Mutual learning and research messages: India, UK, and Europe

Kalra

Bhugra

2010

Indian J Psychiatry

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India and UK have had a long history together, since the times of the British Raj. Most of what Indian psychiatry is today, finds its roots in ancient Indian texts and medicine systems as much as it is influenced by the European system. Psychiatric research in India is growing. It is being influenced by research in the UK and Europe and is influencing them at the same time. In addition to the sharing of ideas and the know-how, there has also been a good amount of sharing of mental health professionals and research samples in the form of immigrants from India to the UK. The Indian mental health professionals based in UK have done a good amount of research with a focus on these Indian immigrants, giving an insight into cross-cultural aspects of some major psychiatric disorders. This article discusses the impact that research in these countries has had on each other and the contributions that have resulted from it.

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“…Furthermore, verapamil not only affects macrophage efflux pumps but also has been identified as an inhibitor of Mycobacterium tuberculosis efflux systems (17)(18)(19)(20). Besides, verapamil is widely used for the treatment of cardiovascular diseases, in contrast to several other EPIs which are not registered yet or have been withdrawn from the market due to severe side effects (21)(22)(23).…”

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confidence: 99%

Assessment of the Additional Value of Verapamil to a Moxifloxacin and Linezolid Combination Regimen in a Murine Tuberculosis Model

Pieterman¹,

Brake

Knegt³

et al. 2018

Antimicrob Agents Chemother

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The favorable treatment outcome rate for multidrug-resistant tuberculosis (MDR-TB) is only 54%, and therefore new drug regimens are urgently needed. In this study, we evaluated the activity of the combination of moxifloxacin and linezolid as a possible new MDR-TB regimen in a murine TB model and the value of the addition of the efflux pump inhibitor verapamil to this backbone. BALB/c mice were infected with drug-sensitive and were treated with human-equivalent doses of moxifloxacin (200 mg/kg of body weight) and linezolid (100 mg/kg) with or without verapamil (12.5 mg/kg) for 12 weeks. Pharmacokinetic parameters were collected during treatment at the steady state. After 12 weeks of treatment, a statistically significant decline in mycobacterial load in the lungs was observed with the moxifloxacin-linezolid regimen with and without verapamil (5.9 and 5.0 log CFU, respectively), but sterilization was not achieved yet. The spleens of all mice were culture negative after 12 weeks of treatment with both treatment modalities, and the addition of verapamil caused a significant reduction in relapse (14/14 positive spleens without versus 9/15 with verapamil, = 0.017). In conclusion, treatment with a combination regimen of moxifloxacin and linezolid showed a strong decline in mycobacterial load in the mice. The addition of verapamil to this backbone had a modest additional effect in terms of reducing mycobacterial load in the lung as well as reducing the spleen relapse rate. These results warrant further studies on the role of efflux pump inhibition in improving the efficacy of MDR-TB backbone regimens.

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Priapismo como presentación inicial de leucemia mieloide crónica

Abstract: We report the case of a 29 years old patient who presented, in the last three moths, four episodes of priapism without any other symptoms and any previous traumatism. An hemogram reveled that the repeted episodes of priapism were caused by a chronic myeloid leukaemia.

Cited by 27 publications

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Comparative effects of Rauwolfia vomitoria and chlorpromazine on social behaviour and pain

Comparative effects of Rauwolfia vomitoria and chlorpromazine on social behaviour and pain

Mutual learning and research messages: India, UK, and Europe

Assessment of the Additional Value of Verapamil to a Moxifloxacin and Linezolid Combination Regimen in a Murine Tuberculosis Model

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